FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157498518> ?p ?o ?g. }

• W3157498518 abstract "Bone cancer pain (BCP) is a clinical refractory mixed pain involving neuropathic and inflammatory pain, with the underlying mechanisms remaining largely unknown. Electro-acupuncture (EA) can partly alleviate BCP according to previous research. We aim to explore the proteins and major pathways involved in BCP and EA treatment through phosphoproteomic profiling. BCP rat model was built by tibial inoculation of MRMT-1 mammary gland carcinoma cells. Mechanical hyperalgesia determined by paw withdrawal thresholds (PWTs) and bone destruction manifested on the radiographs confirmed the success of modeling, which were attenuated by EA treatment. The differentially expressed phosphorylated proteins (DEPs) co-regulated by BCP modeling and EA treatment in rat dorsal root ganglions (DRGs) were analyzed through PEX100 Protein microarray. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that DEPs were significantly enriched in mammalian target of rapamycin (mTOR) signaling pathway. The phosphorylations of mTOR at Ser2448 and Thr2446 were increased in BCP and downregulated by EA. In addition, the phosphorylation of S6K and Akt, markers of the mTOR complex, were also increased in BCP and downregulated by EA. Inhibition of mTOR signaling alleviated the PWTs of BCP rats, while the mTOR agonist impaired the analgesic effect of EA. Thus, our study provided a landscape of protein phosphorylation changes in DRGs of EA-treated BCP rats and revealed that mTOR signaling can be potentially targeted to alleviate BCP by EA treatment." @default.
• W3157498518 created "2021-05-10" @default.
• W3157498518 creator A5011159919 @default.
• W3157498518 creator A5011600927 @default.
• W3157498518 creator A5021150892 @default.
• W3157498518 creator A5030516770 @default.
• W3157498518 creator A5036609300 @default.
• W3157498518 creator A5043092538 @default.
• W3157498518 creator A5048547838 @default.
• W3157498518 creator A5049242358 @default.
• W3157498518 creator A5055648058 @default.
• W3157498518 creator A5061519111 @default.
• W3157498518 creator A5073467023 @default.
• W3157498518 creator A5077086042 @default.
• W3157498518 date "2021-04-29" @default.
• W3157498518 modified "2023-10-14" @default.
• W3157498518 title "Phosphoproteomic Profiling of Rat’s Dorsal Root Ganglia Reveals mTOR as a Potential Target in Bone Cancer Pain and Electro-Acupuncture’s Analgesia" @default.
• W3157498518 cites W1967871273 @default.
• W3157498518 cites W1981869145 @default.
• W3157498518 cites W1984736455 @default.
• W3157498518 cites W1985467148 @default.
• W3157498518 cites W1989658063 @default.
• W3157498518 cites W1992746048 @default.
• W3157498518 cites W1999563475 @default.
• W3157498518 cites W2004980946 @default.
• W3157498518 cites W2005426891 @default.
• W3157498518 cites W2009839085 @default.
• W3157498518 cites W2019350328 @default.
• W3157498518 cites W2019401506 @default.
• W3157498518 cites W2035772147 @default.
• W3157498518 cites W2039286479 @default.
• W3157498518 cites W2040107213 @default.
• W3157498518 cites W2046509144 @default.
• W3157498518 cites W2051590011 @default.
• W3157498518 cites W2070454921 @default.
• W3157498518 cites W2080802044 @default.
• W3157498518 cites W2085319027 @default.
• W3157498518 cites W2086636804 @default.
• W3157498518 cites W2089391233 @default.
• W3157498518 cites W2092458500 @default.
• W3157498518 cites W2110443482 @default.
• W3157498518 cites W2114796502 @default.
• W3157498518 cites W2117028091 @default.
• W3157498518 cites W2121596941 @default.
• W3157498518 cites W2132513385 @default.
• W3157498518 cites W2146272767 @default.
• W3157498518 cites W2152289580 @default.
• W3157498518 cites W2159714906 @default.
• W3157498518 cites W2160880580 @default.
• W3157498518 cites W2161962336 @default.
• W3157498518 cites W2172201406 @default.
• W3157498518 cites W2172395749 @default.
• W3157498518 cites W2309351027 @default.
• W3157498518 cites W2322107141 @default.
• W3157498518 cites W2337210803 @default.
• W3157498518 cites W2396579854 @default.
• W3157498518 cites W2509955348 @default.
• W3157498518 cites W2572903306 @default.
• W3157498518 cites W2577770849 @default.
• W3157498518 cites W2586974477 @default.
• W3157498518 cites W2613532744 @default.
• W3157498518 cites W2738380761 @default.
• W3157498518 cites W2748426090 @default.
• W3157498518 cites W2752198960 @default.
• W3157498518 cites W2762921962 @default.
• W3157498518 cites W2792383110 @default.
• W3157498518 cites W2889646458 @default.
• W3157498518 cites W2891086610 @default.
• W3157498518 cites W2895923601 @default.
• W3157498518 cites W2905458924 @default.
• W3157498518 cites W2911793745 @default.
• W3157498518 cites W2933879324 @default.
• W3157498518 cites W2947736682 @default.
• W3157498518 cites W2955823801 @default.
• W3157498518 cites W2963153905 @default.
• W3157498518 cites W2976550534 @default.
• W3157498518 cites W2989575247 @default.
• W3157498518 cites W2992592621 @default.
• W3157498518 cites W2994810976 @default.
• W3157498518 cites W2996431766 @default.
• W3157498518 cites W2996495425 @default.
• W3157498518 cites W2998046159 @default.
• W3157498518 cites W2999456158 @default.
• W3157498518 cites W3008834816 @default.
• W3157498518 cites W3040600898 @default.
• W3157498518 cites W3091817342 @default.
• W3157498518 cites W3112110309 @default.
• W3157498518 cites W4238567307 @default.
• W3157498518 doi "https://doi.org/10.3389/fphar.2021.593043" @default.
• W3157498518 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8117331" @default.
• W3157498518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33995007" @default.
• W3157498518 hasPublicationYear "2021" @default.
• W3157498518 type Work @default.
• W3157498518 sameAs 3157498518 @default.
• W3157498518 citedByCount "5" @default.
• W3157498518 countsByYear W31574985182022 @default.
• W3157498518 countsByYear W31574985182023 @default.
• W3157498518 crossrefType "journal-article" @default.
• W3157498518 hasAuthorship W3157498518A5011159919 @default.
• W3157498518 hasAuthorship W3157498518A5011600927 @default.

• next