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- W3157595329 abstract "Resveratrol (RES) is a polyphenol with increasing interest for its inhibitory effects on a wide variety of viruses. Zika virus (ZIKV) is an arbovirus which causes a broad spectrum of ophthalmological manifestations in humans. Currently there is no certified therapy or vaccine to treat it, thus it has become a major global health threat. Retinal pigment epithelium (RPE) is highly permissive and susceptible to ZIKV. This work explored the protective effects of RES on ZIKV-infected human RPE cells. RES treatment resulted in a significant reduction of infectious viral particles in infected male ARPE-19 and female hTERT-RPE1 cells. This protection was positively influenced by the action of RES on mitochondrial dynamics. Also, docking studies predicted that RES has a high affinity for two enzymes of the rate-limiting steps of pyrimidine and purine biosynthesis and viral polymerase. This evidence suggests that RES might be a potential antiviral agent to treat ZIKV-induced ocular abnormalities." @default.
- W3157595329 created "2021-05-10" @default.
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- W3157595329 date "2021-07-01" @default.
- W3157595329 modified "2023-10-17" @default.
- W3157595329 title "Antiviral bioactivity of resveratrol against Zika virus infection in human retinal pigment epithelial cells" @default.
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- W3157595329 doi "https://doi.org/10.1007/s11033-021-06490-y" @default.
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