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- W3157597006 abstract "The Drosophila type II neuroblast lineages present an attractive model to investigate the neurogenesis and differentiation process as they adapt to a process similar to that in the human outer subventricular zone. We perform targeted single-cell mRNA sequencing in third instar larval brains to study this process of the type II NB lineage. Combining prior knowledge, in silico analyses, and in situ validation, our multi-informatic investigation describes the molecular landscape from a single developmental snapshot. 17 markers are identified to differentiate distinct maturation stages. 30 markers are identified to specify the stem cell origin and/or cell division numbers of INPs, and at least 12 neuronal subtypes are identified. To foster future discoveries, we provide annotated tables of pairwise gene-gene correlation in single cells and MiCV, a web tool for interactively analyzing scRNA-seq datasets. Taken together, these resources advance our understanding of the neural differentiation process at the molecular level." @default.
- W3157597006 created "2021-05-10" @default.
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- W3157597006 date "2021-04-01" @default.
- W3157597006 modified "2023-10-14" @default.
- W3157597006 title "The molecular landscape of neural differentiation in the developing Drosophila brain revealed by targeted scRNA-seq and multi-informatic analysis" @default.
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- W3157597006 doi "https://doi.org/10.1016/j.celrep.2021.109039" @default.
- W3157597006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8139287" @default.
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