FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157607105> ?p ?o ?g. }

• W3157607105 abstract "Glycerol monolaurate (GML), a naturally occurring monoglyceride, is widely used commercially for its antimicrobial properties. Interestingly, several studies have shown that GML not only has antimicrobial properties but is also an anti-inflammatory agent. GML inhibits peripheral blood mononuclear cell proliferation and inhibits T cell receptor (TCR)-induced signaling events. In this study, we perform an extensive structure activity relationship analysis to investigate the structural components of GML necessary for its suppression of human T cell activation. Human T cells were treated with analogs of GML, differing in acyl chain length, head group, linkage of acyl chain, and number of laurate groups. Treated cells were then tested for changes in membrane dynamics, LAT clustering, calcium signaling, and cytokine production. We found that an acyl chain with 12-14 carbons, a polar head group, an ester linkage, and a single laurate group at any position are all necessary for GML to inhibit protein clustering, calcium signaling, and cytokine production. Removing the glycerol head group or replacing the ester linkage with a nitrogen prevented derivative-mediated inhibition of protein cluster formation and calcium signaling, while still inhibiting TCR-induced cytokine production. These findings expand our current understanding of the mechanisms of action of GML and the of GML needed to function as a novel immunosuppressant." @default.
• W3157607105 created "2021-05-10" @default.
• W3157607105 creator A5006169079 @default.
• W3157607105 creator A5006262029 @default.
• W3157607105 creator A5013701270 @default.
• W3157607105 creator A5036652862 @default.
• W3157607105 creator A5046247522 @default.
• W3157607105 creator A5047715979 @default.
• W3157607105 creator A5048479987 @default.
• W3157607105 creator A5053263322 @default.
• W3157607105 date "2021-04-26" @default.
• W3157607105 modified "2023-10-16" @default.
• W3157607105 title "Suppression of human T cell activation by derivatives of glycerol monolaurate" @default.
• W3157607105 cites W1564861448 @default.
• W3157607105 cites W1646849085 @default.
• W3157607105 cites W1984117933 @default.
• W3157607105 cites W1992271384 @default.
• W3157607105 cites W1995015659 @default.
• W3157607105 cites W2009415301 @default.
• W3157607105 cites W2014281547 @default.
• W3157607105 cites W2029469607 @default.
• W3157607105 cites W2035186660 @default.
• W3157607105 cites W2036885855 @default.
• W3157607105 cites W2040098705 @default.
• W3157607105 cites W2041812843 @default.
• W3157607105 cites W2070883788 @default.
• W3157607105 cites W2072208556 @default.
• W3157607105 cites W2100412095 @default.
• W3157607105 cites W2104415568 @default.
• W3157607105 cites W2105308087 @default.
• W3157607105 cites W2112645064 @default.
• W3157607105 cites W2135630804 @default.
• W3157607105 cites W2137561154 @default.
• W3157607105 cites W2138691817 @default.
• W3157607105 cites W2151497263 @default.
• W3157607105 cites W2156634132 @default.
• W3157607105 cites W2157523956 @default.
• W3157607105 cites W2161358581 @default.
• W3157607105 cites W2335345046 @default.
• W3157607105 cites W2502536698 @default.
• W3157607105 cites W2537147906 @default.
• W3157607105 cites W2801198350 @default.
• W3157607105 cites W2979383858 @default.
• W3157607105 doi "https://doi.org/10.1038/s41598-021-88584-y" @default.
• W3157607105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8076190" @default.
• W3157607105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33903712" @default.
• W3157607105 hasPublicationYear "2021" @default.
• W3157607105 type Work @default.
• W3157607105 sameAs 3157607105 @default.
• W3157607105 citedByCount "7" @default.
• W3157607105 countsByYear W31576071052022 @default.
• W3157607105 countsByYear W31576071052023 @default.
• W3157607105 crossrefType "journal-article" @default.
• W3157607105 hasAuthorship W3157607105A5006169079 @default.
• W3157607105 hasAuthorship W3157607105A5006262029 @default.
• W3157607105 hasAuthorship W3157607105A5013701270 @default.
• W3157607105 hasAuthorship W3157607105A5036652862 @default.
• W3157607105 hasAuthorship W3157607105A5046247522 @default.
• W3157607105 hasAuthorship W3157607105A5047715979 @default.
• W3157607105 hasAuthorship W3157607105A5048479987 @default.
• W3157607105 hasAuthorship W3157607105A5053263322 @default.
• W3157607105 hasBestOaLocation W31576071051 @default.
• W3157607105 hasConcept C185592680 @default.
• W3157607105 hasConcept C19317047 @default.
• W3157607105 hasConcept C203014093 @default.
• W3157607105 hasConcept C2776090121 @default.
• W3157607105 hasConcept C2778690821 @default.
• W3157607105 hasConcept C2780881558 @default.
• W3157607105 hasConcept C55493867 @default.
• W3157607105 hasConcept C62112901 @default.
• W3157607105 hasConcept C86803240 @default.
• W3157607105 hasConcept C8891405 @default.
• W3157607105 hasConceptScore W3157607105C185592680 @default.
• W3157607105 hasConceptScore W3157607105C19317047 @default.
• W3157607105 hasConceptScore W3157607105C203014093 @default.
• W3157607105 hasConceptScore W3157607105C2776090121 @default.
• W3157607105 hasConceptScore W3157607105C2778690821 @default.
• W3157607105 hasConceptScore W3157607105C2780881558 @default.
• W3157607105 hasConceptScore W3157607105C55493867 @default.
• W3157607105 hasConceptScore W3157607105C62112901 @default.
• W3157607105 hasConceptScore W3157607105C86803240 @default.
• W3157607105 hasConceptScore W3157607105C8891405 @default.
• W3157607105 hasFunder F4320332161 @default.
• W3157607105 hasFunder F4320333120 @default.
• W3157607105 hasIssue "1" @default.
• W3157607105 hasLocation W31576071051 @default.
• W3157607105 hasLocation W31576071052 @default.
• W3157607105 hasLocation W31576071053 @default.
• W3157607105 hasLocation W31576071054 @default.
• W3157607105 hasOpenAccess W3157607105 @default.
• W3157607105 hasPrimaryLocation W31576071051 @default.
• W3157607105 hasRelatedWork W1879036459 @default.
• W3157607105 hasRelatedWork W2019123127 @default.
• W3157607105 hasRelatedWork W2031127500 @default.
• W3157607105 hasRelatedWork W2038383170 @default.
• W3157607105 hasRelatedWork W2322724820 @default.
• W3157607105 hasRelatedWork W2551919732 @default.
• W3157607105 hasRelatedWork W3023567007 @default.
• W3157607105 hasRelatedWork W4247125370 @default.
• W3157607105 hasRelatedWork W631190123 @default.

• next