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- W3157613162 abstract "Abstract Background and aims The association between hysterectomy and cardiovascular disease (CVD) remains controversial and research focusing on different types of CVD, especially ischemic heart disease, is scant. Methods This observational study was conducted with the National Health and Nutrition Examination Survey (NHANES) 2007–2018 using propensity score matching, propensity score overlap weighting, and logistic regression. Results Among 15,257 women, 3476 (22.78%) had hysterectomy. Compared with non-hysterectomized women, hysterectomized women are more likely to be older, obese, with lower education level, and lower annual family income. Less favorable outcomes often occurred in unadjusted analysis. In adjusted, matched, and weighted analyses, the associations between hysterectomy and all outcomes were consistent, including ischemic heart disease (ORunadjusted = 3.18[95%CI, 2.76–3.66]; ORadjusted = 1.38[95%CI, 1.09–1.73]; ORmatched = 1.37[95%CI, 1.07–1.75]; ORweighted = 1.38[95%CI, 1.12–1.71]), coronary heart disease (ORunadjusted = 3.31[95%CI, 2.71–4.05]; ORadjusted = 1.43[95%CI, 1.04–1.98]; ORmatched = 1.46[95%CI, 1.04–2.05]; ORweighted = 1.45[95%CI, 1.06–1.99]), heart attack (ORunadjusted = 3.04[95%CI, 2.51–3.68]; ORadjusted = 1.47[95%CI, 1.09–1.99]; ORmatched = 1.42[95%CI, 1.03–1.95]; ORweighted = 1.45[95%CI, 1.10–1.91]) and angina pectoris (ORunadjusted = 3.29[95%CI, 2.66–4.08]; ORadjusted = 1.34[95%CI, 0.95–1.89]; ORmatched = 1.30[95%CI, 0.91–1.87]; ORweighted = 1.33[95%CI, 0.98–1.81]). In hysterectomized women, there were no significant associations between bilateral ovariectomy and ischemic heart disease (ORunadjusted = 1.24[95%CI, 0.99–1.54]; ORadjusted = 1.05[95%CI, 0.80–1.38]; ORmatched = 1.16[95%CI, 0.86–1.55]; ORweighted = 0.93[95%CI, 0.68–1.27]), female hormones use and ischemic heart disease (ORunadjusted = 0.94[95%CI, 0.76–1.16]; ORadjusted = 0.81[95%CI, 0.62–1.07]; ORmatched = 0.89[95%CI, 0.66–1.20]; ORweighted = 1.14[95%CI, 0.88–1.49]). Conclusions Hysterectomy may increase the risk of ischemic heart disease, especially for coronary heart disease and heart attack, but not for angina pectoris. As for the hysterectomized women, bilateral ovariectomy and female hormones use do not affect ischemic heart disease." @default.
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- W3157613162 date "2021-06-01" @default.
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- W3157613162 title "Hysterectomy and ischemic heart disease: An observational study using propensity score methods in NHANES 2007–2018" @default.
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- W3157613162 doi "https://doi.org/10.1016/j.atherosclerosis.2021.04.009" @default.
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