FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157636124> ?p ?o ?g. }

• W3157636124 endingPage "786" @default.
• W3157636124 startingPage "776" @default.
• W3157636124 abstract "Approximately 2%–3% of the population suffers from obsessive–compulsive disorder (OCD). Several brain regions have been implicated in the pathophysiology of OCD, but their various contributions remain unclear. We examined changes in structural and functional neuroimaging before and after a variety of therapeutic interventions as an index into identifying the underlying networks involved. We identified 64 studies from 1990 to 2020 comparing pretreatment and post-treatment imaging of patients with OCD, including metabolic and perfusion, neurochemical, structural, functional and connectivity-based modalities. Treatment class included pharmacotherapy, cognitive–behavioural therapy/exposure and response prevention, stereotactic lesions, deep brain stimulation and transcranial magnetic stimulation. Changes in several brain regions are consistent and correspond with treatment response despite the heterogeneity in treatments and neuroimaging modalities. Most notable are decreases in metabolism and perfusion of the caudate, anterior cingulate cortex, thalamus and regions of prefrontal cortex (PFC) including the orbitofrontal cortex (OFC), dorsolateral PFC (DLPFC), ventromedial PFC (VMPFC) and ventrolateral PFC (VLPFC). Modulating activity within regions of the cortico-striato-thalamo-cortical system may be a common therapeutic mechanism across treatments. We identify future needs and current knowledge gaps that can be mitigated by implementing integrative methods. Future studies should incorporate a systematic, analytical approach to testing objective correlates of treatment response to better understand neurophysiological mechanisms of dysfunction." @default.
• W3157636124 created "2021-05-10" @default.
• W3157636124 creator A5014105109 @default.
• W3157636124 creator A5041442122 @default.
• W3157636124 creator A5043243224 @default.
• W3157636124 creator A5061925949 @default.
• W3157636124 creator A5064007787 @default.
• W3157636124 creator A5082661128 @default.
• W3157636124 creator A5089897759 @default.
• W3157636124 date "2021-04-27" @default.
• W3157636124 modified "2023-10-18" @default.
• W3157636124 title "Defining functional brain networks underlying obsessive–compulsive disorder (OCD) using treatment-induced neuroimaging changes: a systematic review of the literature" @default.
• W3157636124 cites W1964698313 @default.
• W3157636124 cites W1965534174 @default.
• W3157636124 cites W1968419455 @default.
• W3157636124 cites W1972138240 @default.
• W3157636124 cites W1974537105 @default.
• W3157636124 cites W1975222549 @default.
• W3157636124 cites W1975820384 @default.
• W3157636124 cites W1979334190 @default.
• W3157636124 cites W1986388990 @default.
• W3157636124 cites W2003308426 @default.
• W3157636124 cites W2012635324 @default.
• W3157636124 cites W2013041188 @default.
• W3157636124 cites W2015036471 @default.
• W3157636124 cites W2016652427 @default.
• W3157636124 cites W2018881274 @default.
• W3157636124 cites W2021782736 @default.
• W3157636124 cites W2026197907 @default.
• W3157636124 cites W2030652305 @default.
• W3157636124 cites W2045983513 @default.
• W3157636124 cites W2048123183 @default.
• W3157636124 cites W2051663718 @default.
• W3157636124 cites W2053626793 @default.
• W3157636124 cites W2054462180 @default.
• W3157636124 cites W2060280330 @default.
• W3157636124 cites W2062477851 @default.
• W3157636124 cites W2064330399 @default.
• W3157636124 cites W2068738379 @default.
• W3157636124 cites W2070671537 @default.
• W3157636124 cites W2073516522 @default.
• W3157636124 cites W2074416005 @default.
• W3157636124 cites W2074621444 @default.
• W3157636124 cites W2076016857 @default.
• W3157636124 cites W2076256173 @default.
• W3157636124 cites W2078129701 @default.
• W3157636124 cites W2084388248 @default.
• W3157636124 cites W2089183450 @default.
• W3157636124 cites W2097417832 @default.
• W3157636124 cites W2100861230 @default.
• W3157636124 cites W2107610137 @default.
• W3157636124 cites W2116859990 @default.
• W3157636124 cites W2121035887 @default.
• W3157636124 cites W2124987494 @default.
• W3157636124 cites W2125285320 @default.
• W3157636124 cites W2125394189 @default.
• W3157636124 cites W2127350926 @default.
• W3157636124 cites W2152962921 @default.
• W3157636124 cites W2153281793 @default.
• W3157636124 cites W2160832790 @default.
• W3157636124 cites W2164863209 @default.
• W3157636124 cites W2166371058 @default.
• W3157636124 cites W2168383630 @default.
• W3157636124 cites W2169031866 @default.
• W3157636124 cites W2229016060 @default.
• W3157636124 cites W2395864704 @default.
• W3157636124 cites W2801297904 @default.
• W3157636124 cites W2801359753 @default.
• W3157636124 cites W2802374064 @default.
• W3157636124 cites W2908564764 @default.
• W3157636124 cites W2972367292 @default.
• W3157636124 cites W3000525333 @default.
• W3157636124 cites W4239154108 @default.
• W3157636124 doi "https://doi.org/10.1136/jnnp-2020-324478" @default.
• W3157636124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8223624" @default.
• W3157636124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33906936" @default.
• W3157636124 hasPublicationYear "2021" @default.
• W3157636124 type Work @default.
• W3157636124 sameAs 3157636124 @default.
• W3157636124 citedByCount "20" @default.
• W3157636124 countsByYear W31576361242021 @default.
• W3157636124 countsByYear W31576361242022 @default.
• W3157636124 countsByYear W31576361242023 @default.
• W3157636124 crossrefType "journal-article" @default.
• W3157636124 hasAuthorship W3157636124A5014105109 @default.
• W3157636124 hasAuthorship W3157636124A5041442122 @default.
• W3157636124 hasAuthorship W3157636124A5043243224 @default.
• W3157636124 hasAuthorship W3157636124A5061925949 @default.
• W3157636124 hasAuthorship W3157636124A5064007787 @default.
• W3157636124 hasAuthorship W3157636124A5082661128 @default.
• W3157636124 hasAuthorship W3157636124A5089897759 @default.
• W3157636124 hasBestOaLocation W31576361241 @default.
• W3157636124 hasConcept C15744967 @default.
• W3157636124 hasConcept C169760540 @default.
• W3157636124 hasConcept C169900460 @default.
• W3157636124 hasConcept C24998067 @default.
• W3157636124 hasConcept C25876315 @default.
• W3157636124 hasConcept C2776559556 @default.

• next