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• W3157643715 endingPage "107443" @default.
• W3157643715 startingPage "107443" @default.
• W3157643715 abstract "Translating results from pre-clinical animal studies to successful human clinical trials in neurodegenerative and neuropsychiatric disease presents a significant challenge. While this issue is clearly multifaceted, the lack of reproducibility and poor translational validity of many paradigms used to assess cognition in animal models are central contributors to this challenge. Computer-automated cognitive test batteries have the potential to substantially improve translation between pre-clinical studies and clinical trials by increasing both reproducibility and translational validity. Given the structured nature of data output, computer-automated tests also lend themselves to increased data sharing and other open science good practices. Over the past two decades, computer automated, touchscreen-based cognitive testing methods have been developed for non-human primate and rodent models. These automated methods lend themselves to increased standardization, hence reproducibility, and have become increasingly important for the elucidation of the neurobiological basis of cognition in animal models. More recently, there have been increased efforts to use these methods to enhance translational validity by developing task batteries that are nearly identical across different species via forward (i.e., translating animal tasks to humans) and reverse (i.e., translating human tasks to animals) translation. An additional benefit of the touchscreen approach is that a cross-species cognitive test battery makes it possible to implement co-clinical trials-an approach developed initially in cancer research-for novel treatments for neurodegenerative disorders. Co-clinical trials bring together pre-clinical and early clinical studies, which facilitates testing of novel treatments in mouse models with underlying genetic or other changes, and can help to stratify patients on the basis of genetic, molecular, or cognitive criteria. This approach can help to determine which patients should be enrolled in specific clinical trials and can facilitate repositioning and/or repurposing of previously approved drugs. This has the potential to mitigate the resources required to study treatment responses in large numbers of human patients." @default.
• W3157643715 created "2021-05-10" @default.
• W3157643715 creator A5035829537 @default.
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• W3157643715 creator A5086642545 @default.
• W3157643715 date "2021-07-01" @default.
• W3157643715 modified "2023-10-16" @default.
• W3157643715 title "Touchscreen cognitive testing: Cross-species translation and co-clinical trials in neurodegenerative and neuropsychiatric disease" @default.
• W3157643715 cites W1188678028 @default.
• W3157643715 cites W1474197039 @default.
• W3157643715 cites W1502266865 @default.
• W3157643715 cites W1504529133 @default.
• W3157643715 cites W1510516129 @default.
• W3157643715 cites W1539213411 @default.
• W3157643715 cites W1544908332 @default.
• W3157643715 cites W1563000606 @default.
• W3157643715 cites W1595562208 @default.
• W3157643715 cites W1746762178 @default.
• W3157643715 cites W1759162153 @default.
• W3157643715 cites W1837409391 @default.
• W3157643715 cites W1908457397 @default.
• W3157643715 cites W1920056916 @default.
• W3157643715 cites W1964095308 @default.
• W3157643715 cites W1965424617 @default.
• W3157643715 cites W1967332436 @default.
• W3157643715 cites W1967721548 @default.
• W3157643715 cites W1968416856 @default.
• W3157643715 cites W1971819054 @default.
• W3157643715 cites W197326298 @default.
• W3157643715 cites W1974692311 @default.
• W3157643715 cites W1975629701 @default.
• W3157643715 cites W1978178338 @default.
• W3157643715 cites W1978217720 @default.
• W3157643715 cites W1986307624 @default.
• W3157643715 cites W1987177328 @default.
• W3157643715 cites W1987709708 @default.
• W3157643715 cites W1988048007 @default.
• W3157643715 cites W1990755823 @default.
• W3157643715 cites W1991426898 @default.
• W3157643715 cites W1993709327 @default.
• W3157643715 cites W1995786746 @default.
• W3157643715 cites W1996522663 @default.
• W3157643715 cites W1998845124 @default.
• W3157643715 cites W1999442037 @default.
• W3157643715 cites W2002181764 @default.
• W3157643715 cites W2003025179 @default.
• W3157643715 cites W2003737825 @default.
• W3157643715 cites W2004329237 @default.
• W3157643715 cites W2005440106 @default.
• W3157643715 cites W2007162302 @default.
• W3157643715 cites W2007466093 @default.
• W3157643715 cites W2009228680 @default.
• W3157643715 cites W2009434646 @default.
• W3157643715 cites W2009792683 @default.
• W3157643715 cites W2013076359 @default.
• W3157643715 cites W2013302756 @default.
• W3157643715 cites W2014640272 @default.
• W3157643715 cites W2018796213 @default.
• W3157643715 cites W2020415498 @default.
• W3157643715 cites W2022342171 @default.
• W3157643715 cites W2022759245 @default.
• W3157643715 cites W2023725147 @default.
• W3157643715 cites W2024214628 @default.
• W3157643715 cites W2025815591 @default.
• W3157643715 cites W2028127185 @default.
• W3157643715 cites W2028340373 @default.
• W3157643715 cites W2029676821 @default.
• W3157643715 cites W2029707852 @default.
• W3157643715 cites W2030602578 @default.
• W3157643715 cites W2030689331 @default.
• W3157643715 cites W2032112059 @default.
• W3157643715 cites W2032405644 @default.
• W3157643715 cites W2036356750 @default.
• W3157643715 cites W2036364968 @default.
• W3157643715 cites W2038904039 @default.
• W3157643715 cites W2039157160 @default.
• W3157643715 cites W2040603332 @default.
• W3157643715 cites W2045753421 @default.
• W3157643715 cites W2046677525 @default.
• W3157643715 cites W2047420624 @default.
• W3157643715 cites W2047587201 @default.
• W3157643715 cites W2049335636 @default.
• W3157643715 cites W2050575874 @default.
• W3157643715 cites W2051802682 @default.
• W3157643715 cites W2051904378 @default.
• W3157643715 cites W2052032617 @default.
• W3157643715 cites W2052180683 @default.
• W3157643715 cites W2053802846 @default.
• W3157643715 cites W2056390240 @default.
• W3157643715 cites W2056558547 @default.
• W3157643715 cites W2056654183 @default.
• W3157643715 cites W2060818037 @default.
• W3157643715 cites W2063297906 @default.
• W3157643715 cites W2069826120 @default.

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