Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157649252> ?p ?o ?g. }
- W3157649252 endingPage "73" @default.
- W3157649252 startingPage "62" @default.
- W3157649252 abstract "The aim of the research work was to investigate the efficacy of cream loaded with lipid nanocarriers (ethosomes) of piperine for the management of atopic dermatitis (AD) in comparison to conventional cream. Ethosomes of piperine were formulated with varying concentration of phosphatidylcholine and ethanol; and evaluated for entrapment efficiency (EE), sedimentation behaviour, vesicle size, zeta potential, in vitro drug release, and shape. Creams loaded with optimized ethosomal dispersion of piperine were formulated and evaluated for physicochemical parameters, ex vivo permeation and drug retention in skin layers. Similarly, conventional creams of piperine in the same concentrations were formulated and evaluated. The optimized ethosomal a conventional cream was evaluated for cytotoxicity using HaCat cell lines and in vivo on BALB/c mice model. The EE (%) and vesicle size was 74.30 ± 3.88% and 318.1 nm, respectively, for optimized ethosomal dispersion. The zeta potential was -32.6 mV and vesicles were spherical in shape. The ethosomal cream showed higher deposition in the epidermis and dermis. The creams were non-cytotoxic to HaCat cell lines. In comparison to the negative control, the ethosomal (0.1%) and conventional (0.125%) cream, both significantly decreased the ear and skin thickness, skin severity; and WBC, granulocytes, and IgE antibodies level in the BALB/c mice model. The efficacy of ethosomal cream was significantly higher than conventional cream as compared to tacrolimus (0.1%). Ethosomal cream of piperine showed good potential for the management of AD in comparison to conventional cream." @default.
- W3157649252 created "2021-05-10" @default.
- W3157649252 creator A5034543704 @default.
- W3157649252 creator A5034545071 @default.
- W3157649252 creator A5045554353 @default.
- W3157649252 date "2021-05-04" @default.
- W3157649252 modified "2023-10-10" @default.
- W3157649252 title "Topical creams of piperine loaded lipid nanocarriers for management of atopic dermatitis: development, characterization, and <i>in vivo</i> investigation using BALB/c mice model" @default.
- W3157649252 cites W1494039521 @default.
- W3157649252 cites W1967770602 @default.
- W3157649252 cites W1972387325 @default.
- W3157649252 cites W1973231585 @default.
- W3157649252 cites W1979462934 @default.
- W3157649252 cites W1993705126 @default.
- W3157649252 cites W1999387064 @default.
- W3157649252 cites W2004004273 @default.
- W3157649252 cites W2018867886 @default.
- W3157649252 cites W2018976775 @default.
- W3157649252 cites W2033381869 @default.
- W3157649252 cites W2055718658 @default.
- W3157649252 cites W2056995401 @default.
- W3157649252 cites W2060320802 @default.
- W3157649252 cites W2065554904 @default.
- W3157649252 cites W2072739735 @default.
- W3157649252 cites W2073707173 @default.
- W3157649252 cites W2078206440 @default.
- W3157649252 cites W2092699991 @default.
- W3157649252 cites W2094151571 @default.
- W3157649252 cites W2097460594 @default.
- W3157649252 cites W2130614990 @default.
- W3157649252 cites W2136181543 @default.
- W3157649252 cites W2147860005 @default.
- W3157649252 cites W2408008959 @default.
- W3157649252 cites W2524051065 @default.
- W3157649252 cites W2539754179 @default.
- W3157649252 cites W2581509014 @default.
- W3157649252 cites W2586546028 @default.
- W3157649252 cites W2606748794 @default.
- W3157649252 cites W2609828650 @default.
- W3157649252 cites W2619428858 @default.
- W3157649252 cites W2795847976 @default.
- W3157649252 cites W2803145452 @default.
- W3157649252 cites W2884244192 @default.
- W3157649252 cites W2890265693 @default.
- W3157649252 cites W2970912848 @default.
- W3157649252 cites W2981848695 @default.
- W3157649252 cites W4232510995 @default.
- W3157649252 doi "https://doi.org/10.1080/08982104.2021.1880436" @default.
- W3157649252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33944670" @default.
- W3157649252 hasPublicationYear "2021" @default.
- W3157649252 type Work @default.
- W3157649252 sameAs 3157649252 @default.
- W3157649252 citedByCount "7" @default.
- W3157649252 countsByYear W31576492522022 @default.
- W3157649252 countsByYear W31576492522023 @default.
- W3157649252 crossrefType "journal-article" @default.
- W3157649252 hasAuthorship W3157649252A5034543704 @default.
- W3157649252 hasAuthorship W3157649252A5034545071 @default.
- W3157649252 hasAuthorship W3157649252A5045554353 @default.
- W3157649252 hasConcept C118995209 @default.
- W3157649252 hasConcept C150903083 @default.
- W3157649252 hasConcept C155672457 @default.
- W3157649252 hasConcept C171250308 @default.
- W3157649252 hasConcept C18150654 @default.
- W3157649252 hasConcept C185592680 @default.
- W3157649252 hasConcept C192562407 @default.
- W3157649252 hasConcept C202751555 @default.
- W3157649252 hasConcept C207001950 @default.
- W3157649252 hasConcept C2780035454 @default.
- W3157649252 hasConcept C2780133158 @default.
- W3157649252 hasConcept C41625074 @default.
- W3157649252 hasConcept C43617362 @default.
- W3157649252 hasConcept C50670333 @default.
- W3157649252 hasConcept C55493867 @default.
- W3157649252 hasConcept C71924100 @default.
- W3157649252 hasConcept C86181022 @default.
- W3157649252 hasConcept C86803240 @default.
- W3157649252 hasConcept C98274493 @default.
- W3157649252 hasConceptScore W3157649252C118995209 @default.
- W3157649252 hasConceptScore W3157649252C150903083 @default.
- W3157649252 hasConceptScore W3157649252C155672457 @default.
- W3157649252 hasConceptScore W3157649252C171250308 @default.
- W3157649252 hasConceptScore W3157649252C18150654 @default.
- W3157649252 hasConceptScore W3157649252C185592680 @default.
- W3157649252 hasConceptScore W3157649252C192562407 @default.
- W3157649252 hasConceptScore W3157649252C202751555 @default.
- W3157649252 hasConceptScore W3157649252C207001950 @default.
- W3157649252 hasConceptScore W3157649252C2780035454 @default.
- W3157649252 hasConceptScore W3157649252C2780133158 @default.
- W3157649252 hasConceptScore W3157649252C41625074 @default.
- W3157649252 hasConceptScore W3157649252C43617362 @default.
- W3157649252 hasConceptScore W3157649252C50670333 @default.
- W3157649252 hasConceptScore W3157649252C55493867 @default.
- W3157649252 hasConceptScore W3157649252C71924100 @default.
- W3157649252 hasConceptScore W3157649252C86181022 @default.
- W3157649252 hasConceptScore W3157649252C86803240 @default.
- W3157649252 hasConceptScore W3157649252C98274493 @default.
- W3157649252 hasIssue "1" @default.