Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157649343> ?p ?o ?g. }
- W3157649343 abstract "Myocardial fibrosis is closely related to high morbidity and mortality. In Inner Mongolia, Gentianella amarella subsp. acuta (Michx.) J.M.Gillett ( G. acuta ) is a kind of tea used to prevent cardiovascular diseases. Bellidifolin (BEL) is an active xanthone molecule from G. acuta that protects against myocardial damage. However, the effects and mechanisms of BEL on myocardial fibrosis have not been reported. In vivo , BEL dampened isoprenaline (ISO)-induced cardiac structure disturbance and collagen deposition. In vitro, BEL inhibited transforming growth factor (TGF)-β1-induced cardiac fibroblast (CF) proliferation. In vivo and in vitro , BEL decreased the expression of α-smooth muscle actin (α-SMA), collagen Ⅰ and Ⅲ, and inhibited TGF-β1/Smads signaling. Additionally, BEL impeded p38 activation and NR4A1 (an endogenous inhibitor for pro-fibrogenic activities of TGF-β1) phosphorylation and inactivation in vitro . In CFs, inhibition of p38 by SB203580 inhibited the phosphorylation of NR4A1 and did not limit Smad3 phosphorylation, and blocking TGF-β signaling by LY2157299 and SB203580 could decrease the expression of α-SMA, collagen I and III. Overall, both cell and animal studies provide a potential role for BEL against myocardial fibrosis by inhibiting the proliferation and phenotypic transformation of CFs. These inhibitory effects might be related to regulating TGF-β1/Smads pathway and p38 signaling and preventing NR4A1 cytoplasmic localization." @default.
- W3157649343 created "2021-05-10" @default.
- W3157649343 creator A5001839464 @default.
- W3157649343 creator A5004206526 @default.
- W3157649343 creator A5010776860 @default.
- W3157649343 creator A5014912512 @default.
- W3157649343 creator A5017145253 @default.
- W3157649343 creator A5029235233 @default.
- W3157649343 creator A5029345852 @default.
- W3157649343 creator A5045758842 @default.
- W3157649343 creator A5061202285 @default.
- W3157649343 creator A5063778683 @default.
- W3157649343 creator A5077997664 @default.
- W3157649343 date "2021-04-30" @default.
- W3157649343 modified "2023-09-26" @default.
- W3157649343 title "Bellidifolin Ameliorates Isoprenaline-Induced Myocardial Fibrosis by Regulating TGF-β1/Smads and p38 Signaling and Preventing NR4A1 Cytoplasmic Localization" @default.
- W3157649343 cites W1897269170 @default.
- W3157649343 cites W1967965542 @default.
- W3157649343 cites W1999131060 @default.
- W3157649343 cites W2015272969 @default.
- W3157649343 cites W2038758551 @default.
- W3157649343 cites W2044529840 @default.
- W3157649343 cites W2059104750 @default.
- W3157649343 cites W2071202484 @default.
- W3157649343 cites W2085383728 @default.
- W3157649343 cites W2085812634 @default.
- W3157649343 cites W2087891654 @default.
- W3157649343 cites W2092233074 @default.
- W3157649343 cites W2105094177 @default.
- W3157649343 cites W2113024711 @default.
- W3157649343 cites W2137864849 @default.
- W3157649343 cites W2148392040 @default.
- W3157649343 cites W2299099463 @default.
- W3157649343 cites W2486230686 @default.
- W3157649343 cites W2491846563 @default.
- W3157649343 cites W2582992509 @default.
- W3157649343 cites W2597639984 @default.
- W3157649343 cites W2602106397 @default.
- W3157649343 cites W2619786084 @default.
- W3157649343 cites W2725690726 @default.
- W3157649343 cites W2729826858 @default.
- W3157649343 cites W2731161562 @default.
- W3157649343 cites W2737156535 @default.
- W3157649343 cites W2750808153 @default.
- W3157649343 cites W2751267267 @default.
- W3157649343 cites W2767014708 @default.
- W3157649343 cites W2768398928 @default.
- W3157649343 cites W2775418122 @default.
- W3157649343 cites W2789086281 @default.
- W3157649343 cites W2803033855 @default.
- W3157649343 cites W2806597351 @default.
- W3157649343 cites W2881438881 @default.
- W3157649343 cites W2885563247 @default.
- W3157649343 cites W2896824926 @default.
- W3157649343 cites W2897860123 @default.
- W3157649343 cites W2898290288 @default.
- W3157649343 cites W2901696074 @default.
- W3157649343 cites W2904098036 @default.
- W3157649343 cites W2905107175 @default.
- W3157649343 cites W2909038341 @default.
- W3157649343 cites W2914927502 @default.
- W3157649343 cites W2926843980 @default.
- W3157649343 cites W2989852521 @default.
- W3157649343 cites W3021849800 @default.
- W3157649343 cites W3040408937 @default.
- W3157649343 doi "https://doi.org/10.3389/fphar.2021.644886" @default.
- W3157649343 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8120298" @default.
- W3157649343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33995055" @default.
- W3157649343 hasPublicationYear "2021" @default.
- W3157649343 type Work @default.
- W3157649343 sameAs 3157649343 @default.
- W3157649343 citedByCount "9" @default.
- W3157649343 countsByYear W31576493432022 @default.
- W3157649343 countsByYear W31576493432023 @default.
- W3157649343 crossrefType "journal-article" @default.
- W3157649343 hasAuthorship W3157649343A5001839464 @default.
- W3157649343 hasAuthorship W3157649343A5004206526 @default.
- W3157649343 hasAuthorship W3157649343A5010776860 @default.
- W3157649343 hasAuthorship W3157649343A5014912512 @default.
- W3157649343 hasAuthorship W3157649343A5017145253 @default.
- W3157649343 hasAuthorship W3157649343A5029235233 @default.
- W3157649343 hasAuthorship W3157649343A5029345852 @default.
- W3157649343 hasAuthorship W3157649343A5045758842 @default.
- W3157649343 hasAuthorship W3157649343A5061202285 @default.
- W3157649343 hasAuthorship W3157649343A5063778683 @default.
- W3157649343 hasAuthorship W3157649343A5077997664 @default.
- W3157649343 hasBestOaLocation W31576493431 @default.
- W3157649343 hasConcept C118131993 @default.
- W3157649343 hasConcept C11960822 @default.
- W3157649343 hasConcept C126322002 @default.
- W3157649343 hasConcept C134018914 @default.
- W3157649343 hasConcept C150903083 @default.
- W3157649343 hasConcept C185592680 @default.
- W3157649343 hasConcept C207001950 @default.
- W3157649343 hasConcept C24998067 @default.
- W3157649343 hasConcept C2776090920 @default.
- W3157649343 hasConcept C2777420927 @default.
- W3157649343 hasConcept C2780559512 @default.
- W3157649343 hasConcept C3018763269 @default.
- W3157649343 hasConcept C51551487 @default.