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- W3157652072 endingPage "148" @default.
- W3157652072 startingPage "139" @default.
- W3157652072 abstract "The study of autophagy in the nervous system has predominantly centered on degeneration. Evidence is now cementing crucial roles for autophagy in neuronal development and growth, especially in axonal and presynaptic compartments. A picture is emerging that autophagy typically promotes the growth of axons and reduces presynaptic stability. Nonetheless, these are not rigid principles, and it remains unclear why autophagy does not always display these relationships during axonal and presynaptic development. Recent progress has identified mechanisms underlying spatiotemporal control of autophagy in neurons and begun to unravel how autophagy is integrated with other cellular processes, such as proteasomal degradation and axon guidance. Ultimately, understanding how autophagy is regulated and its role in the developing nervous system is key to comprehending how the nervous system assembles its stereotyped yet plastic configuration. It is also likely to inform how we think about neurodevelopmental disorders and neurodegenerative diseases." @default.
- W3157652072 created "2021-05-10" @default.
- W3157652072 creator A5009775604 @default.
- W3157652072 creator A5085173519 @default.
- W3157652072 date "2021-08-01" @default.
- W3157652072 modified "2023-10-15" @default.
- W3157652072 title "Autophagy in axonal and presynaptic development" @default.
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