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- W3157653642 abstract "The aim of this study was to synthesize chitosan nanoparticles loaded with rapeseed extract (RPE-CN) and to evaluate its therapeutic effects. The RPE-CNwas synthesized (Ion gelation), characterized (DLS, FTIR, atomic and electron microscopy) and their toxicity was evaluated by MTT method.Anti-inflammatory and pro-apoptotic effects were evaluated by qPCR method. Its antioxidant power was measured by ABTS, DPPH and FRAP methods and CAM method was used to evaluate its anti-angiogenic effects.Treatment with RPE-CN(Ps: 93.81 nm, PDI: 0.3, and ζ p: +35mv) reduced MCF7 cell viability and increased expression of genes associated with apoptosis (Caspase-3 and Caspase-9), inflammation (IL10) and antioxidant (SOD).RPE-CN exhibited notable inhibition in ABTS, DPPH, and Fe3+-TPTZ free radicals. Finally, angiogenesis in CAM tissue was suppressed by the down-regulation of VEGFR gene expression. According to the results, RPE-CN can be introduced as a potential chemo-preventive agent in the treatment of cancer." @default.
- W3157653642 created "2021-05-10" @default.
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- W3157653642 date "2021-04-27" @default.
- W3157653642 modified "2023-10-16" @default.
- W3157653642 title "Fabrication, Characterisation, and Biological Properties of Chitosan Nanoparticles Containing Rapeseed Pollen Extract (RPE) on the MCF-7 Cell Line" @default.
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- W3157653642 doi "https://doi.org/10.1080/10667857.2021.1921099" @default.
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