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- W3157656259 endingPage "3954" @default.
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- W3157656259 abstract "Abstract Nitric oxide (NO), the highly reactive radical gas, provides an attractive strategy in the control of microbial infections. NO not only exhibits bactericidal effect at high concentrations but also prevents bacterial attachment and disperses biofilms at low, nontoxic concentrations, rendering bacteria less tolerant to antibiotic treatment. The endogenously generated NO by airway epithelium in healthy populations significantly contributes to the eradication of invading pathogens. However, this pathway is often compromised in patients suffering from chronic lung infections where biofilms dominate. Thus, exogenous supplementation of NO is suggested to improve the therapeutic outcomes of these infectious diseases. Compared to previous reviews focusing on the mechanism of NO-mediated biofilm inhibition, this review explores the applications of NO for inhibiting biofilms in chronic lung infections. It discusses how abnormal levels of NO in the airways contribute to chronic infections in cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and primary ciliary dyskinesia (PCD) patients and why exogenous NO can be a promising antibiofilm strategy in clinical settings, as well as current and potential in vivo NO delivery methods. Key points • The relationship between abnormal NO levels and biofilm development in lungs • The antibiofilm property of NO and current applications in lungs • Potential NO delivery methods and research directions in the future" @default.
- W3157656259 created "2021-05-10" @default.
- W3157656259 creator A5009418861 @default.
- W3157656259 creator A5075654345 @default.
- W3157656259 creator A5077037025 @default.
- W3157656259 date "2021-05-01" @default.
- W3157656259 modified "2023-10-12" @default.
- W3157656259 title "NO donors and NO delivery methods for controlling biofilms in chronic lung infections" @default.
- W3157656259 cites W100790183 @default.
- W3157656259 cites W110842744 @default.
- W3157656259 cites W1185642504 @default.
- W3157656259 cites W1228700129 @default.
- W3157656259 cites W1479760463 @default.
- W3157656259 cites W1565910228 @default.
- W3157656259 cites W1577805981 @default.
- W3157656259 cites W1618981391 @default.
- W3157656259 cites W173556415 @default.
- W3157656259 cites W1786604115 @default.
- W3157656259 cites W182339630 @default.
- W3157656259 cites W1858547598 @default.
- W3157656259 cites W1861838026 @default.
- W3157656259 cites W1958884576 @default.
- W3157656259 cites W1963635094 @default.
- W3157656259 cites W1964682417 @default.
- W3157656259 cites W1966001744 @default.
- W3157656259 cites W1970638489 @default.
- W3157656259 cites W1970902697 @default.
- W3157656259 cites W1970973349 @default.
- W3157656259 cites W1971500643 @default.
- W3157656259 cites W1972300311 @default.
- W3157656259 cites W1973780833 @default.
- W3157656259 cites W1976302147 @default.
- W3157656259 cites W1976795218 @default.
- W3157656259 cites W1979026472 @default.
- W3157656259 cites W1980656019 @default.
- W3157656259 cites W1981549976 @default.
- W3157656259 cites W1981946882 @default.
- W3157656259 cites W1982455846 @default.
- W3157656259 cites W1984301256 @default.
- W3157656259 cites W1985119228 @default.
- W3157656259 cites W1987036328 @default.
- W3157656259 cites W1988578493 @default.
- W3157656259 cites W1989750005 @default.
- W3157656259 cites W1990029863 @default.
- W3157656259 cites W1991447409 @default.
- W3157656259 cites W1991597890 @default.
- W3157656259 cites W1991653989 @default.
- W3157656259 cites W1993257762 @default.
- W3157656259 cites W1995721699 @default.
- W3157656259 cites W1998513784 @default.
- W3157656259 cites W1998879311 @default.
- W3157656259 cites W2000523615 @default.
- W3157656259 cites W2003084689 @default.
- W3157656259 cites W2008104429 @default.
- W3157656259 cites W2008509462 @default.
- W3157656259 cites W2010116808 @default.
- W3157656259 cites W2011582460 @default.
- W3157656259 cites W2016588367 @default.
- W3157656259 cites W2017206150 @default.
- W3157656259 cites W2017808329 @default.
- W3157656259 cites W2017845623 @default.
- W3157656259 cites W2020887686 @default.
- W3157656259 cites W2021265034 @default.
- W3157656259 cites W2022400091 @default.
- W3157656259 cites W2024313079 @default.
- W3157656259 cites W2024605770 @default.
- W3157656259 cites W2025943791 @default.
- W3157656259 cites W2026294448 @default.
- W3157656259 cites W2026848798 @default.
- W3157656259 cites W2031815558 @default.
- W3157656259 cites W2032181704 @default.
- W3157656259 cites W2032808656 @default.
- W3157656259 cites W2035226835 @default.
- W3157656259 cites W2038943374 @default.
- W3157656259 cites W2040417898 @default.
- W3157656259 cites W2041283753 @default.
- W3157656259 cites W2044380511 @default.
- W3157656259 cites W2044668858 @default.
- W3157656259 cites W2044780418 @default.
- W3157656259 cites W2044872678 @default.
- W3157656259 cites W2045396791 @default.
- W3157656259 cites W2046864303 @default.
- W3157656259 cites W2047354298 @default.
- W3157656259 cites W2048439065 @default.
- W3157656259 cites W2048826963 @default.
- W3157656259 cites W2050429664 @default.
- W3157656259 cites W2052350481 @default.
- W3157656259 cites W2054510415 @default.
- W3157656259 cites W2055744131 @default.
- W3157656259 cites W2055753580 @default.
- W3157656259 cites W2057460683 @default.
- W3157656259 cites W2057573581 @default.
- W3157656259 cites W2063401681 @default.
- W3157656259 cites W2066837478 @default.
- W3157656259 cites W2067921041 @default.
- W3157656259 cites W2070300719 @default.
- W3157656259 cites W2071193318 @default.
- W3157656259 cites W2071465093 @default.