Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157657612> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W3157657612 endingPage "A376" @default.
- W3157657612 startingPage "A376" @default.
- W3157657612 abstract "Abstract Introduction: Iron overload is a common complication of thalassemia, responsible for multiple organ damage, including pancreas. The prevalence of diabetes in thalassemia was 9.7–29%,1 while the incidence of diabetic ketoacidosis (DKA) is only 0,3%.2 Case Illustration: A 26 year-old male with thalassemia major (TM) admitted due to dyspnea, which later revealed as first episode of DKA. No prior history of hyperglycemia, but the patient has unexplained weight loss. He receives combination of chelators (deferiprone, desferroxamine, deferriprox) with ferritin level 8,387 μg/mL. Serum glucose was remarkably high (690 mg/dL), with ketosis (4.2 μg/dL) and metabolic acidosis (pH 7.2; bicarbonate 5.6 mEq/L). No single insult was identified, but recurrent ventricular tachycardia was documented. T2* MRI demonstrates severe cardiac and mild pancreatic hemosiderosis. Echocardiography shows reduced ejection fraction (25.6%), atrioventricular dilatation, and hypokinetism. Discussion: Impaired glucose metabolism in TM is initially mediated by insulin resistance, but later, the interplay between defect in insulin secretion and resistance determines the various clinical picture of diabetes in TM.3 Several mechanisms have been linked: oxidative stress, induction of autoimmunity, and zinc deficiency; yet, current evidence remains inadequate.4 The T2* MRI provides the most reliable tool to predict the development of glycemic dysregulation, whereas relying solely on ferritin could lead to imprecise measurement of iron deposits.5 The presence of cardiac abnormality might responsible for the DKA and suggests the need of rescue chelation for this patient. Conclusion: DKA is a rare endocrine complications which can be prevented by routine T2* MRI screening and has wide spectrum of clinical characteristics." @default.
- W3157657612 created "2021-05-10" @default.
- W3157657612 creator A5005007244 @default.
- W3157657612 creator A5005334952 @default.
- W3157657612 creator A5041656924 @default.
- W3157657612 creator A5054502877 @default.
- W3157657612 creator A5057039937 @default.
- W3157657612 date "2021-05-01" @default.
- W3157657612 modified "2023-09-23" @default.
- W3157657612 title "Diabetic Ketoacidosis Presenting in Major Thalassemia With Pancreatic Hemosiderosis: A Case Report" @default.
- W3157657612 doi "https://doi.org/10.1210/jendso/bvab048.766" @default.
- W3157657612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8090194" @default.
- W3157657612 hasPublicationYear "2021" @default.
- W3157657612 type Work @default.
- W3157657612 sameAs 3157657612 @default.
- W3157657612 citedByCount "0" @default.
- W3157657612 crossrefType "journal-article" @default.
- W3157657612 hasAuthorship W3157657612A5005007244 @default.
- W3157657612 hasAuthorship W3157657612A5005334952 @default.
- W3157657612 hasAuthorship W3157657612A5041656924 @default.
- W3157657612 hasAuthorship W3157657612A5054502877 @default.
- W3157657612 hasAuthorship W3157657612A5057039937 @default.
- W3157657612 hasBestOaLocation W31576576121 @default.
- W3157657612 hasConcept C126322002 @default.
- W3157657612 hasConcept C134018914 @default.
- W3157657612 hasConcept C164705383 @default.
- W3157657612 hasConcept C2776590208 @default.
- W3157657612 hasConcept C2777799968 @default.
- W3157657612 hasConcept C2778319317 @default.
- W3157657612 hasConcept C2780473172 @default.
- W3157657612 hasConcept C2780622394 @default.
- W3157657612 hasConcept C2781283889 @default.
- W3157657612 hasConcept C555293320 @default.
- W3157657612 hasConcept C71924100 @default.
- W3157657612 hasConcept C90924648 @default.
- W3157657612 hasConceptScore W3157657612C126322002 @default.
- W3157657612 hasConceptScore W3157657612C134018914 @default.
- W3157657612 hasConceptScore W3157657612C164705383 @default.
- W3157657612 hasConceptScore W3157657612C2776590208 @default.
- W3157657612 hasConceptScore W3157657612C2777799968 @default.
- W3157657612 hasConceptScore W3157657612C2778319317 @default.
- W3157657612 hasConceptScore W3157657612C2780473172 @default.
- W3157657612 hasConceptScore W3157657612C2780622394 @default.
- W3157657612 hasConceptScore W3157657612C2781283889 @default.
- W3157657612 hasConceptScore W3157657612C555293320 @default.
- W3157657612 hasConceptScore W3157657612C71924100 @default.
- W3157657612 hasConceptScore W3157657612C90924648 @default.
- W3157657612 hasIssue "Supplement_1" @default.
- W3157657612 hasLocation W31576576121 @default.
- W3157657612 hasLocation W31576576122 @default.
- W3157657612 hasOpenAccess W3157657612 @default.
- W3157657612 hasPrimaryLocation W31576576121 @default.
- W3157657612 hasRelatedWork W2000386537 @default.
- W3157657612 hasRelatedWork W2013197936 @default.
- W3157657612 hasRelatedWork W2019509271 @default.
- W3157657612 hasRelatedWork W2065925758 @default.
- W3157657612 hasRelatedWork W2073843577 @default.
- W3157657612 hasRelatedWork W2092579885 @default.
- W3157657612 hasRelatedWork W2127396703 @default.
- W3157657612 hasRelatedWork W2156949915 @default.
- W3157657612 hasRelatedWork W2579241685 @default.
- W3157657612 hasRelatedWork W4247190821 @default.
- W3157657612 hasVolume "5" @default.
- W3157657612 isParatext "false" @default.
- W3157657612 isRetracted "false" @default.
- W3157657612 magId "3157657612" @default.
- W3157657612 workType "article" @default.