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• W3157659464 endingPage "100911" @default.
• W3157659464 startingPage "100911" @default.
• W3157659464 abstract "Successful colonization of Helicobacter pylori depends on the ability to establish a strong connection between the bacterium and the gastric epithelium. According to recent studies, babA2 plays a pivotal role in the sustainable colonization of this pathogen in the human stomach. This meta-analysis study was performed to evaluate the association between Helicobacter pylori babA2 gene and gastric diseases such as peptic ulcer and gastric cancer in the Iranian population. A comprehensive search was performed using global databases to collect all the studies related to the evaluation of the role of babA2 gene and clinical outcomes in the Iranian population. Eligible studies were quantitatively analyzed according to our criteria and the effect of babA2 on gastric ulcer and gastric cancer was evaluated using the odds ratio with 95% confidence interval. A total of 18 articles were included in the current meta-analysis. The results showed a significant relationship between babA2 gene and the risk of peptic ulcer disease (OR: 1.49, 95% CI: 1.14–1.94). In addition, we found in the subgroup analysis that the babA2 genotype was positively associated with duodenal as well as gastric ulcers (OR: 1.87, 95% CI: 1.28–2.37 and OR: 1.95, 95% CI: 1.11–3.41 respectively). We also showed that there is a positive and significant relationship between babA2 and gastric cancer (OR: 2.4, 95% CI: 1.04–5.52). We observed a significant association between babA2- positive Helicobacter pylori and the development of peptic ulcer disease and gastric cancer in the Iranian population. Our present finding reveals the possibility of the importance of babA2 for development of peptic ulcer and gastric cancer in the Iranian population." @default.
• W3157659464 created "2021-05-10" @default.
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• W3157659464 date "2021-09-01" @default.
• W3157659464 modified "2023-09-24" @default.
• W3157659464 title "Severe clinical outcomes of infection with babA2-positive Helicobacter pylori strains in the Iranian population: A systematic review and meta-analysis" @default.
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• W3157659464 doi "https://doi.org/10.1016/j.mgene.2021.100911" @default.
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