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- W3157670226 abstract "Alzheimer’s disease (AD) is a neurodegenerative disorder of multifactorial origin involving various pathologic processes. Therefore, the classic dogma “one drug, one target” is not appropriate for this disease, and the most promising research drugs act against more than one target (multitarget drugs). So far, the only drugs approved by the FDA and the EMEA to treat AD are acetylcholinesterase inhibitors and N-methyl-D-aspartate receptor antagonists, which have shown low effectiveness. Therefore, this work focuses on the active multitarget drugs in vitro and in vivo, which are currently in clinical trials. We expect some of them will represent a reference treatment in the coming years. Many of the drugs described below act against known targets, such as β-amyloid peptide (Aβ), the Tau protein and the cholinesterase enzyme. However, drugs such as CHF5074, etazolate and ST101 are active against Aβ peptide precursor protein (APP), one therapeutic target of interest. Moreover, some of the drugs in clinical development for AD treatment are already approved for other uses, such as pioglitazone and sargramostim which are commercialized for type II diabetes mellitus and leukemia after bone marrow transplantation, respectively. Nowadays, despite major research efforts in investigation, good results have not been achieved yet. The last drug approved in Spain, memantine, dates from 2003." @default.
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- W3157670226 date "2018-01-01" @default.
- W3157670226 modified "2023-09-23" @default.
- W3157670226 title "Multitarget drugs in clinical development for Alzheimer’s disease treatment" @default.
- W3157670226 hasPublicationYear "2018" @default.
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