Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157674268> ?p ?o ?g. }
- W3157674268 abstract "In early development, the environment triggers mnemonic epigenomic programs resulting in memory and learning experiences to confer cognitive phenotypes into adulthood. To uncover how environmental stimulation impacts the epigenome and genome organization, we used the paradigm of environmental enrichment (EE) in young mice constantly receiving novel stimulation. We profiled epigenome and chromatin architecture in whole cortex and sorted neurons by deep-sequencing techniques. Specifically, we studied chromatin accessibility, gene and protein regulation, and 3D genome conformation, combined with predicted enhancer and chromatin interactions. We identified increased chromatin accessibility, transcription factor binding including CTCF-mediated insulation, differential occupancy of H3K36me3 and H3K79me2, and changes in transcriptional programs required for neuronal development. EE stimuli led to local genome re-organization by inducing increased contacts between chromosomes 7 and 17 (inter-chromosomal). Our findings support the notion that EE-induced learning and memory processes are directly associated with the epigenome and genome organization." @default.
- W3157674268 created "2021-05-10" @default.
- W3157674268 creator A5000636240 @default.
- W3157674268 creator A5004028270 @default.
- W3157674268 creator A5007995198 @default.
- W3157674268 creator A5010534544 @default.
- W3157674268 creator A5013754408 @default.
- W3157674268 creator A5015878199 @default.
- W3157674268 creator A5016966335 @default.
- W3157674268 creator A5018384674 @default.
- W3157674268 creator A5024100392 @default.
- W3157674268 creator A5025313402 @default.
- W3157674268 creator A5025600687 @default.
- W3157674268 creator A5035087236 @default.
- W3157674268 creator A5035820223 @default.
- W3157674268 creator A5052090214 @default.
- W3157674268 creator A5064009710 @default.
- W3157674268 creator A5086975302 @default.
- W3157674268 creator A5088012592 @default.
- W3157674268 date "2021-05-05" @default.
- W3157674268 modified "2023-10-06" @default.
- W3157674268 title "Environmental Enrichment Induces Epigenomic and Genome Organization Changes Relevant for Cognition" @default.
- W3157674268 cites W1502095375 @default.
- W3157674268 cites W1506343731 @default.
- W3157674268 cites W1941076503 @default.
- W3157674268 cites W1965879419 @default.
- W3157674268 cites W1967137091 @default.
- W3157674268 cites W1972702742 @default.
- W3157674268 cites W1973062929 @default.
- W3157674268 cites W1979676825 @default.
- W3157674268 cites W1982733111 @default.
- W3157674268 cites W1990418954 @default.
- W3157674268 cites W1991543373 @default.
- W3157674268 cites W1997393600 @default.
- W3157674268 cites W2000789056 @default.
- W3157674268 cites W2014787267 @default.
- W3157674268 cites W2025648894 @default.
- W3157674268 cites W2039521726 @default.
- W3157674268 cites W2047535883 @default.
- W3157674268 cites W2054691158 @default.
- W3157674268 cites W2060982963 @default.
- W3157674268 cites W2064625222 @default.
- W3157674268 cites W2066536417 @default.
- W3157674268 cites W2070021921 @default.
- W3157674268 cites W2071027270 @default.
- W3157674268 cites W2071256713 @default.
- W3157674268 cites W2072691491 @default.
- W3157674268 cites W2074078151 @default.
- W3157674268 cites W2079223648 @default.
- W3157674268 cites W2079765578 @default.
- W3157674268 cites W2081098333 @default.
- W3157674268 cites W2081229769 @default.
- W3157674268 cites W2085184586 @default.
- W3157674268 cites W2090037139 @default.
- W3157674268 cites W2092143480 @default.
- W3157674268 cites W2092314927 @default.
- W3157674268 cites W2096034876 @default.
- W3157674268 cites W2096192426 @default.
- W3157674268 cites W2098754973 @default.
- W3157674268 cites W2102973376 @default.
- W3157674268 cites W2103441770 @default.
- W3157674268 cites W2110905563 @default.
- W3157674268 cites W2114104545 @default.
- W3157674268 cites W2114559471 @default.
- W3157674268 cites W2114570899 @default.
- W3157674268 cites W2117391623 @default.
- W3157674268 cites W2117757143 @default.
- W3157674268 cites W2118515267 @default.
- W3157674268 cites W2122037893 @default.
- W3157674268 cites W2124985265 @default.
- W3157674268 cites W2127081697 @default.
- W3157674268 cites W2131374955 @default.
- W3157674268 cites W2131517505 @default.
- W3157674268 cites W2137526110 @default.
- W3157674268 cites W2137841176 @default.
- W3157674268 cites W2138207763 @default.
- W3157674268 cites W2139480055 @default.
- W3157674268 cites W2142410561 @default.
- W3157674268 cites W2146594788 @default.
- W3157674268 cites W2147875291 @default.
- W3157674268 cites W2150936392 @default.
- W3157674268 cites W2155826575 @default.
- W3157674268 cites W2161222316 @default.
- W3157674268 cites W2166803181 @default.
- W3157674268 cites W2167776710 @default.
- W3157674268 cites W2169456326 @default.
- W3157674268 cites W2169589032 @default.
- W3157674268 cites W2171808845 @default.
- W3157674268 cites W2185693210 @default.
- W3157674268 cites W2223740898 @default.
- W3157674268 cites W2305116528 @default.
- W3157674268 cites W2322983281 @default.
- W3157674268 cites W2341539131 @default.
- W3157674268 cites W2395105713 @default.
- W3157674268 cites W2416170699 @default.
- W3157674268 cites W2481029670 @default.
- W3157674268 cites W2487895297 @default.
- W3157674268 cites W2493763501 @default.
- W3157674268 cites W2513995665 @default.
- W3157674268 cites W2526525525 @default.