FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157686072> ?p ?o ?g. }

• W3157686072 abstract "INTRODUCTION: Numerous studies in Huntington’s disease (HD) have shown striatum as the major site of neuronal loss, but recently the presence of neurodegeneration in other regions of the brain is gaining attention. In our study, we used voxel-based morphometry and diffusion tensor imaging to identify other areas in the brain that are involved in the disease. METHODS: The present study is a prospective study conducted in the Departments of Neurology, Psychiatry, and Neuroimaging and Interventional Radiology (NIIR), NIMHANS, Bengaluru. The study included 20 genetically confirmed HD patients and 20 healthy controls. Magnetic resonance imaging was performed on a 3-Tesla Philips Achieva scanner with a 32-channel head coil with the acquisition of whole-brain T1-weighted and DTI. RESULTS: The patients (41.25 ± 10.04 years) and controls (38.27 ± 11.29 years) were age-matched (P = 0.38), and the mean age at the onset of the symptoms of the disease was 37.53 ± 10.11 years, and the expanded CAG repeat allele was 45.95 ± 7.27 (range 40–73) repeats. All patients had psychiatric symptoms at presentation such as anger outbursts, irritability, abusive behavior, apathy, low mood, crying spells, delusions, lack of initiation, and obsessive–compulsive disorder. Compared with controls, HD patients had significant atrophy of bilateral caudate nuclei, right globus pallidus, left culmen, right precuneus, hypothalamus, and right superior temporal gyrus. Fractional anisotropy was increased in bilateral cerebral white matter and thalamus with the reduction in mean diffusivity. CONCLUSIONS: In addition to atrophy of caudate, atrophy was also observed in globus pallidus, thalamus, hypothalamus and right superior temporal gyrus. This may explain the neuropsychiatric and cognitive symptoms observed in these patients." @default.
• W3157686072 created "2021-05-10" @default.
• W3157686072 creator A5006776113 @default.
• W3157686072 creator A5008732476 @default.
• W3157686072 creator A5008786091 @default.
• W3157686072 creator A5026751784 @default.
• W3157686072 creator A5037746317 @default.
• W3157686072 creator A5066942811 @default.
• W3157686072 creator A5075826065 @default.
• W3157686072 creator A5077448329 @default.
• W3157686072 date "2021-01-01" @default.
• W3157686072 modified "2023-09-25" @default.
• W3157686072 title "Neural substrates of psychiatric symptoms in patients with Huntington’s Disease" @default.
• W3157686072 doi "https://doi.org/10.4103/aomd.aomd_39_20" @default.
• W3157686072 hasPublicationYear "2021" @default.
• W3157686072 type Work @default.
• W3157686072 sameAs 3157686072 @default.
• W3157686072 citedByCount "0" @default.
• W3157686072 crossrefType "journal-article" @default.
• W3157686072 hasAuthorship W3157686072A5006776113 @default.
• W3157686072 hasAuthorship W3157686072A5008732476 @default.
• W3157686072 hasAuthorship W3157686072A5008786091 @default.
• W3157686072 hasAuthorship W3157686072A5026751784 @default.
• W3157686072 hasAuthorship W3157686072A5037746317 @default.
• W3157686072 hasAuthorship W3157686072A5066942811 @default.
• W3157686072 hasAuthorship W3157686072A5075826065 @default.
• W3157686072 hasAuthorship W3157686072A5077448329 @default.
• W3157686072 hasBestOaLocation W31576860721 @default.
• W3157686072 hasConcept C118552586 @default.
• W3157686072 hasConcept C126322002 @default.
• W3157686072 hasConcept C15744967 @default.
• W3157686072 hasConcept C169760540 @default.
• W3157686072 hasConcept C2779134260 @default.
• W3157686072 hasConcept C2780647506 @default.
• W3157686072 hasConcept C71924100 @default.
• W3157686072 hasConceptScore W3157686072C118552586 @default.
• W3157686072 hasConceptScore W3157686072C126322002 @default.
• W3157686072 hasConceptScore W3157686072C15744967 @default.
• W3157686072 hasConceptScore W3157686072C169760540 @default.
• W3157686072 hasConceptScore W3157686072C2779134260 @default.
• W3157686072 hasConceptScore W3157686072C2780647506 @default.
• W3157686072 hasConceptScore W3157686072C71924100 @default.
• W3157686072 hasLocation W31576860721 @default.
• W3157686072 hasLocation W31576860722 @default.
• W3157686072 hasOpenAccess W3157686072 @default.
• W3157686072 hasPrimaryLocation W31576860721 @default.
• W3157686072 hasRelatedWork W1566646394 @default.
• W3157686072 hasRelatedWork W1985353896 @default.
• W3157686072 hasRelatedWork W2030725658 @default.
• W3157686072 hasRelatedWork W2033553670 @default.
• W3157686072 hasRelatedWork W2134794586 @default.
• W3157686072 hasRelatedWork W2153163442 @default.
• W3157686072 hasRelatedWork W2748952813 @default.
• W3157686072 hasRelatedWork W2765379856 @default.
• W3157686072 hasRelatedWork W2899084033 @default.
• W3157686072 hasRelatedWork W3109409261 @default.
• W3157686072 isParatext "false" @default.
• W3157686072 isRetracted "false" @default.
• W3157686072 magId "3157686072" @default.
• W3157686072 workType "article" @default.