FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157693271> ?p ?o ?g. }

• W3157693271 abstract "Abstract Introduction: Primary hyperparathyroidism (PHPT) is rarely diagnosed in pregnancy and if left untreated has the potential to lead to serious maternal and neonatal complications. We describe a case of PHPT with associated complicated pre-eclampsia. Clinical Case29-year-old primigravida admitted at 33 + 6 weeks with fatigue, 10lbs weight gain and elevated BP. Labs revealed potassium 2.9 (3.5-5.2mmol/L), corrected serum calcium (Ca)11.62 (8.4-10.2mg/dL), ionized calcium 1.69 (1.15-1.33mmol/L), PTH 163.9 (15-65pg/mL) and vitamin D 24.6 (30-100ng/mL). Other labs were normal. Urine studies showed 315mg/24h proteinuria and urine calcium of 129.5 mg/24hrs (100-300mg/24hrs). She was started on magnesium sulphate along with labetalol for BP control, given betamethasone for stimulation of fetal lung maturity as well as potassium repletion. Hypercalcemia (HCa) was initially managed with fluids and Lasix intravenously. At 34 + 2 weeks she developed SOB, orthopnea, headaches with new 9lbs weight gain over 5 days and sustained BP elevation. Urgent C-section was done for pre-eclampsia with severe features. Post-operatively, she suffered from postpartum hemorrhage, managed with transfusion of packed red cells and transient placement of a Bakri balloon. Her HCa worsened with Ca 12.56 and cinacalcet was started after delivery. This coincided with gradual improvement of her BP and Ca to 10.8. She declined additional work-up and was discharged in stable condition. Clinical LessonPHPT often goes undiagnosed in pregnancy, with symptoms of fatigue and constipation mimicking common complaints of pregnancy. Studies have also suggested that up to 25% of patients with PHPT during pregnancy present with hypertension and pre-eclampsia and that there is an association between preeclampsia and the presence of parathyroid adenomas. The pathophysiology is unclear but is thought to be due to endothelial dysfunction triggered by hypercalcemia as well as abnormal placentation. No clear guidelines exist for the management of PHPT during pregnancy, with observation and rehydration being the preferred initial options. The use of cinacalcet as well as curative surgical parathyroidectomy when Ca levels persist &gt;11 in the second trimester have also been described. Our patient presented similarly, with severe pre-eclampsia needing urgent C-section, further complicated by persistent severe HCa. Early diagnosis of PHPT, along with treatment including cinacalcet improved her Ca. It is therefore important that PHPT be considered in patients presenting like ours, progressing to severe pre-eclampsia as early reduction of serum calcium may reduce morbidity and mortality. ReferencesMcCarthy, A., Howarth, S., Khoo, S., Hale, J., Oddy, S., Halsall, D., ... & Samyraju, M. (2019). Management of primary hyperparathyroidism in pregnancy: a case series. Endocrinology, diabetes & metabolism case reports, 2019(1)." @default.
• W3157693271 created "2021-05-10" @default.
• W3157693271 creator A5020032133 @default.
• W3157693271 creator A5028861396 @default.
• W3157693271 creator A5047207387 @default.
• W3157693271 creator A5064330376 @default.
• W3157693271 creator A5067436076 @default.
• W3157693271 creator A5077246072 @default.
• W3157693271 creator A5079367523 @default.
• W3157693271 date "2021-05-01" @default.
• W3157693271 modified "2023-10-14" @default.
• W3157693271 title "Pre-Eclampsia Strikes: Could It Be Related This Gland?" @default.
• W3157693271 doi "https://doi.org/10.1210/jendso/bvab048.1594" @default.
• W3157693271 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8090094" @default.
• W3157693271 hasPublicationYear "2021" @default.
• W3157693271 type Work @default.
• W3157693271 sameAs 3157693271 @default.
• W3157693271 citedByCount "0" @default.
• W3157693271 crossrefType "journal-article" @default.
• W3157693271 hasAuthorship W3157693271A5020032133 @default.
• W3157693271 hasAuthorship W3157693271A5028861396 @default.
• W3157693271 hasAuthorship W3157693271A5047207387 @default.
• W3157693271 hasAuthorship W3157693271A5064330376 @default.
• W3157693271 hasAuthorship W3157693271A5067436076 @default.
• W3157693271 hasAuthorship W3157693271A5077246072 @default.
• W3157693271 hasAuthorship W3157693271A5079367523 @default.
• W3157693271 hasBestOaLocation W31576932711 @default.
• W3157693271 hasConcept C126322002 @default.
• W3157693271 hasConcept C141071460 @default.
• W3157693271 hasConcept C2777218350 @default.
• W3157693271 hasConcept C2779234561 @default.
• W3157693271 hasConcept C2779561371 @default.
• W3157693271 hasConcept C2780091579 @default.
• W3157693271 hasConcept C2780966972 @default.
• W3157693271 hasConcept C2781276381 @default.
• W3157693271 hasConcept C42219234 @default.
• W3157693271 hasConcept C54355233 @default.
• W3157693271 hasConcept C71924100 @default.
• W3157693271 hasConcept C86803240 @default.
• W3157693271 hasConcept C90924648 @default.
• W3157693271 hasConceptScore W3157693271C126322002 @default.
• W3157693271 hasConceptScore W3157693271C141071460 @default.
• W3157693271 hasConceptScore W3157693271C2777218350 @default.
• W3157693271 hasConceptScore W3157693271C2779234561 @default.
• W3157693271 hasConceptScore W3157693271C2779561371 @default.
• W3157693271 hasConceptScore W3157693271C2780091579 @default.
• W3157693271 hasConceptScore W3157693271C2780966972 @default.
• W3157693271 hasConceptScore W3157693271C2781276381 @default.
• W3157693271 hasConceptScore W3157693271C42219234 @default.
• W3157693271 hasConceptScore W3157693271C54355233 @default.
• W3157693271 hasConceptScore W3157693271C71924100 @default.
• W3157693271 hasConceptScore W3157693271C86803240 @default.
• W3157693271 hasConceptScore W3157693271C90924648 @default.
• W3157693271 hasLocation W31576932711 @default.
• W3157693271 hasLocation W31576932712 @default.
• W3157693271 hasOpenAccess W3157693271 @default.
• W3157693271 hasPrimaryLocation W31576932711 @default.
• W3157693271 hasRelatedWork W2002389743 @default.
• W3157693271 hasRelatedWork W2010635385 @default.
• W3157693271 hasRelatedWork W2041517107 @default.
• W3157693271 hasRelatedWork W2104083182 @default.
• W3157693271 hasRelatedWork W2295442952 @default.
• W3157693271 hasRelatedWork W2356012341 @default.
• W3157693271 hasRelatedWork W2367337329 @default.
• W3157693271 hasRelatedWork W2375475008 @default.
• W3157693271 hasRelatedWork W2377228219 @default.
• W3157693271 hasRelatedWork W86568313 @default.
• W3157693271 isParatext "false" @default.
• W3157693271 isRetracted "false" @default.
• W3157693271 magId "3157693271" @default.
• W3157693271 workType "article" @default.