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- W3157693984 endingPage "2026" @default.
- W3157693984 startingPage "2006" @default.
- W3157693984 abstract "The NF-κB transcription factor c-Rel is a critical regulator of Treg ontogeny, controlling multiple points of the stepwise developmental pathway. Here, we found that the thymic Treg defect in c-Rel-deficient (cRel–/–) mice is quantitative, not qualitative, based on analyses of TCR repertoire and TCR signaling strength. However, these parameters are altered in the thymic Treg-precursor population, which is also markedly diminished in cRel–/– mice. Moreover, c-Rel governs the transcriptional programme of both thymic and peripheral Tregs, controlling a core of genes involved with immune signaling, and separately in the periphery, cell cycle progression. Last, the immune suppressive function of peripheral cRel–/– tTregs is diminished in a lymphopenic model of T cell proliferation and is associated with decreased stability of Foxp3 expression. Collectively, we show that c-Rel is a transcriptional regulator that controls multiple aspects of Treg development, differentiation, and function via distinct mechanisms." @default.
- W3157693984 created "2021-05-10" @default.
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- W3157693984 date "2021-05-29" @default.
- W3157693984 modified "2023-10-06" @default.
- W3157693984 title "c‐Rel employs multiple mechanisms to promote the thymic development and peripheral function of regulatory T cells in mice" @default.
- W3157693984 cites W1512887516 @default.
- W3157693984 cites W1518759830 @default.
- W3157693984 cites W1524506477 @default.
- W3157693984 cites W1575585006 @default.
- W3157693984 cites W1862842949 @default.
- W3157693984 cites W1878828051 @default.
- W3157693984 cites W1896419045 @default.
- W3157693984 cites W195650535 @default.
- W3157693984 cites W1966073503 @default.
- W3157693984 cites W1973750557 @default.
- W3157693984 cites W1978073168 @default.
- W3157693984 cites W1983755969 @default.
- W3157693984 cites W1986219494 @default.
- W3157693984 cites W1987735044 @default.
- W3157693984 cites W1988193284 @default.
- W3157693984 cites W1990773604 @default.
- W3157693984 cites W1992662011 @default.
- W3157693984 cites W1999625746 @default.
- W3157693984 cites W2000628284 @default.
- W3157693984 cites W2002726823 @default.
- W3157693984 cites W2003257616 @default.
- W3157693984 cites W2004708987 @default.
- W3157693984 cites W2005415198 @default.
- W3157693984 cites W2011873300 @default.
- W3157693984 cites W2014346117 @default.
- W3157693984 cites W2014634158 @default.
- W3157693984 cites W2017217637 @default.
- W3157693984 cites W2021249461 @default.
- W3157693984 cites W2022825068 @default.
- W3157693984 cites W2023999210 @default.
- W3157693984 cites W2026189702 @default.
- W3157693984 cites W2029893930 @default.
- W3157693984 cites W2030284768 @default.
- W3157693984 cites W2033262429 @default.
- W3157693984 cites W2036782104 @default.
- W3157693984 cites W2037433323 @default.
- W3157693984 cites W2042166751 @default.
- W3157693984 cites W2051241958 @default.
- W3157693984 cites W2063223775 @default.
- W3157693984 cites W2064573340 @default.
- W3157693984 cites W2065547728 @default.
- W3157693984 cites W2073563548 @default.
- W3157693984 cites W2074632761 @default.
- W3157693984 cites W2077402228 @default.
- W3157693984 cites W2080935386 @default.
- W3157693984 cites W2081090613 @default.
- W3157693984 cites W2083305728 @default.
- W3157693984 cites W2083391898 @default.
- W3157693984 cites W2088608418 @default.
- W3157693984 cites W2092789549 @default.
- W3157693984 cites W2093135504 @default.
- W3157693984 cites W2093982674 @default.
- W3157693984 cites W2096589599 @default.
- W3157693984 cites W2097811455 @default.
- W3157693984 cites W2100142435 @default.
- W3157693984 cites W2100276321 @default.
- W3157693984 cites W2101974006 @default.
- W3157693984 cites W2102377692 @default.
- W3157693984 cites W2103336148 @default.
- W3157693984 cites W2104919278 @default.
- W3157693984 cites W2105983154 @default.
- W3157693984 cites W2106667865 @default.
- W3157693984 cites W2112024377 @default.
- W3157693984 cites W2112498628 @default.
- W3157693984 cites W2115452562 @default.
- W3157693984 cites W2120010406 @default.
- W3157693984 cites W2120702484 @default.
- W3157693984 cites W2125164691 @default.
- W3157693984 cites W2126214983 @default.
- W3157693984 cites W2127605217 @default.
- W3157693984 cites W2130486201 @default.
- W3157693984 cites W2136408524 @default.
- W3157693984 cites W2138207763 @default.
- W3157693984 cites W2139250592 @default.
- W3157693984 cites W2139771438 @default.
- W3157693984 cites W2143417567 @default.
- W3157693984 cites W2147638016 @default.
- W3157693984 cites W2157804243 @default.