FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157699994> ?p ?o ?g. }

• W3157699994 endingPage "628" @default.
• W3157699994 startingPage "628" @default.
• W3157699994 abstract "Cohort studies show better survival after breast-conserving surgery (BCS) with postoperative radiotherapy (RT) than after mastectomy (Mx) without RT. It remains unclear whether this is an independent effect or a consequence of selection bias.To determine whether the reported survival benefit of breast conservation is eliminated by adjustment for 2 pivotal confounders, comorbidity and socioeconomic status.Cohort study using prospectively collected national data. Swedish public health care; nationwide clinical data from the National Breast Cancer Quality Register, comorbidity data from Patient Registers at the National Board of Health and Welfare, and individual-level education and income data from Statistics Sweden. The cohort included all women diagnosed as having primary invasive T1-2 N0-2 breast cancer and undergoing breast surgery in Sweden from 2008 to 2017. Data were analyzed between August 19, 2020, and November 12, 2020.Locoregional treatment comparing 3 groups: breast-conserving surgery with radiotherapy (BCS+RT), mastectomy without radiotherapy (Mx-RT), and mastectomy with radiotherapy (Mx+RT).Overall survival (OS) and breast cancer-specific survival (BCSS). Main outcomes were determined before initiation of data retrieval.Among 48 986 women, 29 367 (59.9%) had BCS+RT, 12413 (25.3%) had Mx-RT, and 7206 (14.7%) had Mx+RT. Median follow-up was 6.28 years (range, 0.01-11.70). All-cause death occurred in 6573 cases, with death caused by breast cancer in 2313 cases; 5-year OS was 91.1% (95% CI, 90.8-91.3) and BCSS was 96.3% (95% CI, 96.1-96.4). Apart from expected differences in clinical parameters, women receiving Mx-RT were older, had a lower level of education, and lower income. Both Mx groups had a higher comorbidity burden irrespective of RT. After stepwise adjustment for all covariates, OS and BCSS were significantly worse after Mx-RT (hazard ratio [HR], 1.79; 95% CI, 1.66-1.92 and HR, 1.66; 95% CI, 1.45-1.90, respectively) and Mx+RT (HR, 1.24; 95% CI, 1.13-1.37 and HR, 1.26; 95% CI, 1.08-1.46, respectively) than after BCS+RT.Despite adjustment for previously unmeasured confounders, BCS+RT yielded better survival than Mx irrespective of RT. If both interventions are valid options, mastectomy should not be regarded as equal to breast conservation." @default.
• W3157699994 created "2021-05-10" @default.
• W3157699994 creator A5025808995 @default.
• W3157699994 creator A5048731831 @default.
• W3157699994 creator A5080806833 @default.
• W3157699994 date "2021-07-01" @default.
• W3157699994 modified "2023-10-16" @default.
• W3157699994 title "Survival After Breast Conservation vs Mastectomy Adjusted for Comorbidity and Socioeconomic Status" @default.
• W3157699994 cites W1017651675 @default.
• W3157699994 cites W1964752628 @default.
• W3157699994 cites W1965411645 @default.
• W3157699994 cites W1985360994 @default.
• W3157699994 cites W2012130476 @default.
• W3157699994 cites W2066801367 @default.
• W3157699994 cites W2070782275 @default.
• W3157699994 cites W2072645850 @default.
• W3157699994 cites W2074494628 @default.
• W3157699994 cites W2089885033 @default.
• W3157699994 cites W2113953300 @default.
• W3157699994 cites W2118961573 @default.
• W3157699994 cites W2127960841 @default.
• W3157699994 cites W2130746306 @default.
• W3157699994 cites W2140043363 @default.
• W3157699994 cites W2407995910 @default.
• W3157699994 cites W2467949803 @default.
• W3157699994 cites W2569820896 @default.
• W3157699994 cites W2752343661 @default.
• W3157699994 cites W2771527259 @default.
• W3157699994 cites W2800844960 @default.
• W3157699994 cites W2809297981 @default.
• W3157699994 cites W2922454366 @default.
• W3157699994 cites W2922459755 @default.
• W3157699994 cites W2947890877 @default.
• W3157699994 cites W2987050609 @default.
• W3157699994 cites W2991742203 @default.
• W3157699994 cites W4238693266 @default.
• W3157699994 cites W4240543862 @default.
• W3157699994 cites W4245617872 @default.
• W3157699994 doi "https://doi.org/10.1001/jamasurg.2021.1438" @default.
• W3157699994 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8100916" @default.
• W3157699994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33950173" @default.
• W3157699994 hasPublicationYear "2021" @default.
• W3157699994 type Work @default.
• W3157699994 sameAs 3157699994 @default.
• W3157699994 citedByCount "104" @default.
• W3157699994 countsByYear W31576999942021 @default.
• W3157699994 countsByYear W31576999942022 @default.
• W3157699994 countsByYear W31576999942023 @default.
• W3157699994 crossrefType "journal-article" @default.
• W3157699994 hasAuthorship W3157699994A5025808995 @default.
• W3157699994 hasAuthorship W3157699994A5048731831 @default.
• W3157699994 hasAuthorship W3157699994A5080806833 @default.
• W3157699994 hasBestOaLocation W31576999941 @default.
• W3157699994 hasConcept C121608353 @default.
• W3157699994 hasConcept C126322002 @default.
• W3157699994 hasConcept C143998085 @default.
• W3157699994 hasConcept C147077947 @default.
• W3157699994 hasConcept C201903717 @default.
• W3157699994 hasConcept C2777757722 @default.
• W3157699994 hasConcept C2778527826 @default.
• W3157699994 hasConcept C2779159551 @default.
• W3157699994 hasConcept C2781467025 @default.
• W3157699994 hasConcept C2908647359 @default.
• W3157699994 hasConcept C29456083 @default.
• W3157699994 hasConcept C50382708 @default.
• W3157699994 hasConcept C509974204 @default.
• W3157699994 hasConcept C530470458 @default.
• W3157699994 hasConcept C71924100 @default.
• W3157699994 hasConcept C72563966 @default.
• W3157699994 hasConcept C99454951 @default.
• W3157699994 hasConceptScore W3157699994C121608353 @default.
• W3157699994 hasConceptScore W3157699994C126322002 @default.
• W3157699994 hasConceptScore W3157699994C143998085 @default.
• W3157699994 hasConceptScore W3157699994C147077947 @default.
• W3157699994 hasConceptScore W3157699994C201903717 @default.
• W3157699994 hasConceptScore W3157699994C2777757722 @default.
• W3157699994 hasConceptScore W3157699994C2778527826 @default.
• W3157699994 hasConceptScore W3157699994C2779159551 @default.
• W3157699994 hasConceptScore W3157699994C2781467025 @default.
• W3157699994 hasConceptScore W3157699994C2908647359 @default.
• W3157699994 hasConceptScore W3157699994C29456083 @default.
• W3157699994 hasConceptScore W3157699994C50382708 @default.
• W3157699994 hasConceptScore W3157699994C509974204 @default.
• W3157699994 hasConceptScore W3157699994C530470458 @default.
• W3157699994 hasConceptScore W3157699994C71924100 @default.
• W3157699994 hasConceptScore W3157699994C72563966 @default.
• W3157699994 hasConceptScore W3157699994C99454951 @default.
• W3157699994 hasIssue "7" @default.
• W3157699994 hasLocation W31576999941 @default.
• W3157699994 hasLocation W31576999942 @default.
• W3157699994 hasLocation W31576999943 @default.
• W3157699994 hasOpenAccess W3157699994 @default.
• W3157699994 hasPrimaryLocation W31576999941 @default.
• W3157699994 hasRelatedWork W1579354567 @default.
• W3157699994 hasRelatedWork W2096421053 @default.
• W3157699994 hasRelatedWork W2106175699 @default.
• W3157699994 hasRelatedWork W2106734666 @default.
• W3157699994 hasRelatedWork W2137538576 @default.

• next