FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157706781> ?p ?o ?g. }

• W3157706781 endingPage "574" @default.
• W3157706781 startingPage "558" @default.
• W3157706781 abstract "Gliomas are the most common type of malignant brain tumors. Despite significant medical advances, gliomas remain incurable and are associated with high mortality. Although numerous biomarkers of diagnostic value have been identified and significant progress in the prognosis of the outcome has been made, the treatment has not been parallelly improved during the last three decades. This review summarizes and discusses three aspects of recent discoveries related to glioma, with the objective to highlight the advantages of glioma-specific drugs targeting the cell of origin, microenvironment, and metabolism. Given the heterogeneous nature of gliomas, various cell populations have been implicated as likely sources of the tumor. Depending on the mutation(s) acquired by the cells, it is believed that neural stem/progenitor cells, oligodendrocyte progenitor cells, mature neurons, and glial cells can initiate cell transformation into a malignant phenotype. The level of tumorigenicity appears to be inversely correlated with the maturation of a given cell population. The microenvironment of gliomas includes non-cancer cells such as immune cells, fibroblasts, and cells of blood vessels, as well as secreted molecules and the extracellular matrix, and all these components play a vital role during tumor initiation and progression. We will discuss in detail how the tumor microenvironment can stimulate and drive the transformation of non-tumor cell populations into tumor-supporting cells or glioma cells. Metabolic reprogramming is a key feature of gliomas and is thought to reflect the adaptation to the increased nutritional requirements of tumor cell proliferation, growth, and survival. Mutations in the IDH gene can shape metabolic reprogramming and may generate some vulnerabilities in glioma cells, such as abnormal lipid metabolism and sensitivity to endoplasmic reticulum stress (ERS). We will analyze the prominent metabolic features of malignant gliomas and the key pathways regulating glioma metabolism. This review is intended to provide a conceptual background for the development of glioma therapies based on the properties of tumor cell populations, microenvironment, and metabolism." @default.
• W3157706781 created "2021-05-10" @default.
• W3157706781 creator A5000733968 @default.
• W3157706781 creator A5005087915 @default.
• W3157706781 creator A5015946020 @default.
• W3157706781 creator A5036427905 @default.
• W3157706781 creator A5048026374 @default.
• W3157706781 creator A5065104542 @default.
• W3157706781 creator A5085030292 @default.
• W3157706781 creator A5085142676 @default.
• W3157706781 date "2021-08-01" @default.
• W3157706781 modified "2023-10-17" @default.
• W3157706781 title "Rediscovering Potential Molecular Targets for Glioma Therapy Through the Analysis of the Cell of Origin, Microenvironment and Metabolism" @default.
• W3157706781 cites W1493231819 @default.
• W3157706781 cites W1506672302 @default.
• W3157706781 cites W1971526515 @default.
• W3157706781 cites W1973740519 @default.
• W3157706781 cites W1988756388 @default.
• W3157706781 cites W1991250346 @default.
• W3157706781 cites W1994563291 @default.
• W3157706781 cites W2006167464 @default.
• W3157706781 cites W2008437801 @default.
• W3157706781 cites W2010677999 @default.
• W3157706781 cites W2011642035 @default.
• W3157706781 cites W2012588998 @default.
• W3157706781 cites W2012957035 @default.
• W3157706781 cites W2013521084 @default.
• W3157706781 cites W2019820235 @default.
• W3157706781 cites W2022233569 @default.
• W3157706781 cites W2024791894 @default.
• W3157706781 cites W2025511820 @default.
• W3157706781 cites W2026541878 @default.
• W3157706781 cites W2032159281 @default.
• W3157706781 cites W2032975646 @default.
• W3157706781 cites W2045000546 @default.
• W3157706781 cites W2053442171 @default.
• W3157706781 cites W2053693308 @default.
• W3157706781 cites W2059071540 @default.
• W3157706781 cites W2059884965 @default.
• W3157706781 cites W2060895562 @default.
• W3157706781 cites W2063346847 @default.
• W3157706781 cites W2066796446 @default.
• W3157706781 cites W2073302269 @default.
• W3157706781 cites W2080452140 @default.
• W3157706781 cites W2081119605 @default.
• W3157706781 cites W2086506873 @default.
• W3157706781 cites W2087200546 @default.
• W3157706781 cites W2093016929 @default.
• W3157706781 cites W2100260504 @default.
• W3157706781 cites W2104419412 @default.
• W3157706781 cites W2104917184 @default.
• W3157706781 cites W2109531556 @default.
• W3157706781 cites W2112286580 @default.
• W3157706781 cites W2117577687 @default.
• W3157706781 cites W2119836524 @default.
• W3157706781 cites W2120820989 @default.
• W3157706781 cites W2129515878 @default.
• W3157706781 cites W2130388134 @default.
• W3157706781 cites W2131860315 @default.
• W3157706781 cites W2132555177 @default.
• W3157706781 cites W2147730829 @default.
• W3157706781 cites W2148156107 @default.
• W3157706781 cites W2149914697 @default.
• W3157706781 cites W2151980465 @default.
• W3157706781 cites W2154313451 @default.
• W3157706781 cites W2157904425 @default.
• W3157706781 cites W2162184748 @default.
• W3157706781 cites W2171026968 @default.
• W3157706781 cites W2172266256 @default.
• W3157706781 cites W2174361280 @default.
• W3157706781 cites W2220215167 @default.
• W3157706781 cites W2234115940 @default.
• W3157706781 cites W2293141975 @default.
• W3157706781 cites W2312738416 @default.
• W3157706781 cites W2344065596 @default.
• W3157706781 cites W2346921492 @default.
• W3157706781 cites W2366536035 @default.
• W3157706781 cites W2443613404 @default.
• W3157706781 cites W2460811760 @default.
• W3157706781 cites W2517137498 @default.
• W3157706781 cites W2527734859 @default.
• W3157706781 cites W2530768869 @default.
• W3157706781 cites W2542563686 @default.
• W3157706781 cites W2547097019 @default.
• W3157706781 cites W2570043843 @default.
• W3157706781 cites W2587111601 @default.
• W3157706781 cites W2599750069 @default.
• W3157706781 cites W2599827930 @default.
• W3157706781 cites W2600519390 @default.
• W3157706781 cites W2611063290 @default.
• W3157706781 cites W2617597517 @default.
• W3157706781 cites W2739293386 @default.
• W3157706781 cites W2741593581 @default.
• W3157706781 cites W2744123648 @default.
• W3157706781 cites W2750179473 @default.
• W3157706781 cites W2758553652 @default.
• W3157706781 cites W2766586060 @default.
• W3157706781 cites W2768388636 @default.

• next