Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157707413> ?p ?o ?g. }
- W3157707413 abstract "ABSTRACT The nonstructural NS1 protein is a virulence factor secreted by dengue virus (DENV)-infected cells. NS1 is known to alter the complement system, activate immune cells and perturb endothelial barriers. Here we show that pro-inflammatory signals are triggered by a high affinity complex formed between NS1 and human high-density lipoproteins (HDL). Electron microscopy images of the NS1-HDL complexes show spherical HDL particles with rod-shaped NS1 protrusions on their surface. These complexes are readily detectable in the plasma of hospitalized dengue patients using anti-apolipoprotein A-I (ApoA-I) antibodies specific of the HDL moiety. The functional reprogramming of HDL particles by the NS1 protein as a means to exacerbate systemic inflammation during DENV infection provides a new paradigm linking the human lipoprotein network to dengue pathogenesis." @default.
- W3157707413 created "2021-05-10" @default.
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- W3157707413 date "2021-05-05" @default.
- W3157707413 modified "2023-10-17" @default.
- W3157707413 title "The dengue virus NS1 protein conveys pro-inflammatory signals by docking onto human high-density lipoproteins" @default.
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