FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157708927> ?p ?o ?g. }

• W3157708927 endingPage "38" @default.
• W3157708927 startingPage "1" @default.
• W3157708927 abstract "Abstract The seventh edition of Burger's Medicinal Chemistry, Drug Discovery and Development included an extensive review of antimalarial drugs and drug targets. Since it was published nearly 10 years ago, the annual number of deaths due to malaria in endemic countries have steadily declined. However, over the past two years, a stabilization in number of malaria deaths hints to a reversal of this trend. This may be in part due to parasite evolution to overcome efficacy of antimalarial therapies, including the now well‐established spread of resistance to artemisinin‐combination therapies in Southeast Asia. Fortunately, the last decade also witnessed a renewed effort by academic researchers, product development partnerships, and pharmaceutical companies to restart malaria drug discovery. Innovations in high‐throughput screening, assay development, access to large chemical libraries, advancements in parasite biology, and whole‐genome sequencing have resulted in the discovery of new antimalarial drugs as well as novel targets. These new drug candidates, which kill the parasite through new mechanisms of action have bolstered the malaria drug development pipeline since the last edition. This article summarizes the new drug discovery approaches and achievements over the past decade." @default.
• W3157708927 created "2021-05-10" @default.
• W3157708927 creator A5036011732 @default.
• W3157708927 creator A5080340857 @default.
• W3157708927 date "2021-04-26" @default.
• W3157708927 modified "2023-10-16" @default.
• W3157708927 title "2010 to 2020: Ten Years of Malaria Drug Discovery" @default.
• W3157708927 cites W100984399 @default.
• W3157708927 cites W1886463152 @default.
• W3157708927 cites W1935711444 @default.
• W3157708927 cites W1945105808 @default.
• W3157708927 cites W1963097328 @default.
• W3157708927 cites W1963649319 @default.
• W3157708927 cites W1964141703 @default.
• W3157708927 cites W1964597183 @default.
• W3157708927 cites W1966388665 @default.
• W3157708927 cites W1967155346 @default.
• W3157708927 cites W1969443191 @default.
• W3157708927 cites W1969503178 @default.
• W3157708927 cites W1969689914 @default.
• W3157708927 cites W1972641896 @default.
• W3157708927 cites W1973828942 @default.
• W3157708927 cites W1977560610 @default.
• W3157708927 cites W1983330084 @default.
• W3157708927 cites W1983531823 @default.
• W3157708927 cites W1983965298 @default.
• W3157708927 cites W1993251792 @default.
• W3157708927 cites W1993795323 @default.
• W3157708927 cites W1995421796 @default.
• W3157708927 cites W1996418116 @default.
• W3157708927 cites W1996682530 @default.
• W3157708927 cites W1999044153 @default.
• W3157708927 cites W2001062064 @default.
• W3157708927 cites W2001098902 @default.
• W3157708927 cites W2002559872 @default.
• W3157708927 cites W2005376397 @default.
• W3157708927 cites W2006158992 @default.
• W3157708927 cites W2007561244 @default.
• W3157708927 cites W2009259923 @default.
• W3157708927 cites W2009504763 @default.
• W3157708927 cites W2009631075 @default.
• W3157708927 cites W2012789887 @default.
• W3157708927 cites W2014429457 @default.
• W3157708927 cites W2015251548 @default.
• W3157708927 cites W2015787058 @default.
• W3157708927 cites W2015791647 @default.
• W3157708927 cites W2016045984 @default.
• W3157708927 cites W2017114273 @default.
• W3157708927 cites W2017815763 @default.
• W3157708927 cites W2019666716 @default.
• W3157708927 cites W2020621263 @default.
• W3157708927 cites W2024278262 @default.
• W3157708927 cites W2028918918 @default.
• W3157708927 cites W2031441006 @default.
• W3157708927 cites W2034745024 @default.
• W3157708927 cites W2035826427 @default.
• W3157708927 cites W2037350416 @default.
• W3157708927 cites W2038072533 @default.
• W3157708927 cites W2040713555 @default.
• W3157708927 cites W2041863951 @default.
• W3157708927 cites W2048080607 @default.
• W3157708927 cites W2049016946 @default.
• W3157708927 cites W2055958358 @default.
• W3157708927 cites W2057089852 @default.
• W3157708927 cites W2059390272 @default.
• W3157708927 cites W2061033196 @default.
• W3157708927 cites W2064093461 @default.
• W3157708927 cites W2073525920 @default.
• W3157708927 cites W2074412286 @default.
• W3157708927 cites W2076189507 @default.
• W3157708927 cites W2076482938 @default.
• W3157708927 cites W2080430126 @default.
• W3157708927 cites W2080536605 @default.
• W3157708927 cites W2087267967 @default.
• W3157708927 cites W2088380202 @default.
• W3157708927 cites W2088975231 @default.
• W3157708927 cites W2095957613 @default.
• W3157708927 cites W2098184601 @default.
• W3157708927 cites W2102499150 @default.
• W3157708927 cites W2102661218 @default.
• W3157708927 cites W2105491171 @default.
• W3157708927 cites W2105668259 @default.
• W3157708927 cites W2105675932 @default.
• W3157708927 cites W2106374535 @default.
• W3157708927 cites W2110625254 @default.
• W3157708927 cites W2114441270 @default.
• W3157708927 cites W2114818342 @default.
• W3157708927 cites W2116931072 @default.
• W3157708927 cites W2119609695 @default.
• W3157708927 cites W2124462745 @default.
• W3157708927 cites W2124634096 @default.
• W3157708927 cites W2125851600 @default.
• W3157708927 cites W2127703127 @default.
• W3157708927 cites W2129999344 @default.
• W3157708927 cites W2132088083 @default.
• W3157708927 cites W2135700462 @default.
• W3157708927 cites W2135797423 @default.
• W3157708927 cites W2135874703 @default.

• next