Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157712082> ?p ?o ?g. }
- W3157712082 endingPage "8463" @default.
- W3157712082 startingPage "8455" @default.
- W3157712082 abstract "Thymoquinone (TQ) is a bioactive component of medicinal plant, Nigella sativa. It has been identified as promising anti-inflammatory and anti-analgesic properties. In the present study, the TQ has been investigated for physiological interaction as well as binding properties with serum albumin and their thermodynamic parameters at different temperatures. Glycation process was checked with the measurement of fructosamine content, carbonyl content and total advanced glycated end products. The aggregation of amyloid β-structure was measured with Thioflavin-T and the secondary structure of BSA was observed by circular dichroism (CD) in glycated and thermal treated samples. The results indicate that the TQ showed binding interaction (both static and dynamic) with BSA (Kb= 18.31 × 107 M−1 at 293 K) and suppression of glycated products. The glycation-induced and thermal aggregation were prevented and the secondary structure of BSA was maintained. Therefore, these findings suggest that TQ may be used for a therapeutic drug for antiglycation as well as anti-aggregation.Communicated by Ramaswamy H. Sarma" @default.
- W3157712082 created "2021-05-10" @default.
- W3157712082 creator A5019571867 @default.
- W3157712082 creator A5029389611 @default.
- W3157712082 creator A5039036825 @default.
- W3157712082 creator A5054676592 @default.
- W3157712082 creator A5057816442 @default.
- W3157712082 creator A5066799119 @default.
- W3157712082 creator A5070701588 @default.
- W3157712082 date "2021-04-28" @default.
- W3157712082 modified "2023-09-28" @default.
- W3157712082 title "Evaluation of the antiglycating potential of thymoquinone and its interaction with BSA" @default.
- W3157712082 cites W1933264297 @default.
- W3157712082 cites W1968059064 @default.
- W3157712082 cites W1974961786 @default.
- W3157712082 cites W1993288305 @default.
- W3157712082 cites W1994930430 @default.
- W3157712082 cites W2000534488 @default.
- W3157712082 cites W2000550503 @default.
- W3157712082 cites W2007888214 @default.
- W3157712082 cites W2012140419 @default.
- W3157712082 cites W2033474282 @default.
- W3157712082 cites W2045150607 @default.
- W3157712082 cites W2050640675 @default.
- W3157712082 cites W2092674974 @default.
- W3157712082 cites W2098345116 @default.
- W3157712082 cites W2101982331 @default.
- W3157712082 cites W2109116451 @default.
- W3157712082 cites W2130479394 @default.
- W3157712082 cites W2149138461 @default.
- W3157712082 cites W2154853392 @default.
- W3157712082 cites W2170270376 @default.
- W3157712082 cites W2266013672 @default.
- W3157712082 cites W2292665464 @default.
- W3157712082 cites W2363542542 @default.
- W3157712082 cites W2485100474 @default.
- W3157712082 cites W2604345818 @default.
- W3157712082 cites W2605173511 @default.
- W3157712082 cites W2794128681 @default.
- W3157712082 cites W2794653844 @default.
- W3157712082 cites W2807476046 @default.
- W3157712082 cites W2966219758 @default.
- W3157712082 cites W3007923829 @default.
- W3157712082 cites W3034054704 @default.
- W3157712082 cites W3046944605 @default.
- W3157712082 cites W3047828153 @default.
- W3157712082 doi "https://doi.org/10.1080/07391102.2021.1912642" @default.
- W3157712082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33908315" @default.
- W3157712082 hasPublicationYear "2021" @default.
- W3157712082 type Work @default.
- W3157712082 sameAs 3157712082 @default.
- W3157712082 citedByCount "4" @default.
- W3157712082 countsByYear W31577120822022 @default.
- W3157712082 countsByYear W31577120822023 @default.
- W3157712082 crossrefType "journal-article" @default.
- W3157712082 hasAuthorship W3157712082A5019571867 @default.
- W3157712082 hasAuthorship W3157712082A5029389611 @default.
- W3157712082 hasAuthorship W3157712082A5039036825 @default.
- W3157712082 hasAuthorship W3157712082A5054676592 @default.
- W3157712082 hasAuthorship W3157712082A5057816442 @default.
- W3157712082 hasAuthorship W3157712082A5066799119 @default.
- W3157712082 hasAuthorship W3157712082A5070701588 @default.
- W3157712082 hasBestOaLocation W31577120822 @default.
- W3157712082 hasConcept C126322002 @default.
- W3157712082 hasConcept C133571119 @default.
- W3157712082 hasConcept C147990577 @default.
- W3157712082 hasConcept C170493617 @default.
- W3157712082 hasConcept C185592680 @default.
- W3157712082 hasConcept C2778004101 @default.
- W3157712082 hasConcept C2779034068 @default.
- W3157712082 hasConcept C2779306644 @default.
- W3157712082 hasConcept C2781357877 @default.
- W3157712082 hasConcept C43617362 @default.
- W3157712082 hasConcept C55493867 @default.
- W3157712082 hasConcept C62614982 @default.
- W3157712082 hasConcept C71924100 @default.
- W3157712082 hasConcept C98274493 @default.
- W3157712082 hasConceptScore W3157712082C126322002 @default.
- W3157712082 hasConceptScore W3157712082C133571119 @default.
- W3157712082 hasConceptScore W3157712082C147990577 @default.
- W3157712082 hasConceptScore W3157712082C170493617 @default.
- W3157712082 hasConceptScore W3157712082C185592680 @default.
- W3157712082 hasConceptScore W3157712082C2778004101 @default.
- W3157712082 hasConceptScore W3157712082C2779034068 @default.
- W3157712082 hasConceptScore W3157712082C2779306644 @default.
- W3157712082 hasConceptScore W3157712082C2781357877 @default.
- W3157712082 hasConceptScore W3157712082C43617362 @default.
- W3157712082 hasConceptScore W3157712082C55493867 @default.
- W3157712082 hasConceptScore W3157712082C62614982 @default.
- W3157712082 hasConceptScore W3157712082C71924100 @default.
- W3157712082 hasConceptScore W3157712082C98274493 @default.
- W3157712082 hasFunder F4320327498 @default.
- W3157712082 hasIssue "18" @default.
- W3157712082 hasLocation W31577120821 @default.
- W3157712082 hasLocation W31577120822 @default.
- W3157712082 hasLocation W31577120823 @default.
- W3157712082 hasOpenAccess W3157712082 @default.
- W3157712082 hasPrimaryLocation W31577120821 @default.