Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157759545> ?p ?o ?g. }
- W3157759545 endingPage "119538" @default.
- W3157759545 startingPage "119538" @default.
- W3157759545 abstract "Overweight is a major global health problem. Various methodologies to get rid of the extra fat are available, but usually, those are associated with adverse side effects. Probiotics, on the contrary, seem to have the potential to help reduce fat accumulation without much apparent adversity. In this study, we have evaluated a pair of well-documented probiotics for their anti-obesogenic effects. We used strains of Lactobacillus acidophilus (LA) and a cocktail (LDB-ST) of Lactobacillus delbruckei sp. bulgaricus (LDB) and Streptococcus thermophilus (ST) in this study. The murine pre-adipocyte cell line 3T3-L1 was terminally differentiated to matured adipocytes to use as a model to evaluate the bacteria's anti-obesogenic effects. The optimal dose for treatment of both the probiotics was determined using a cell viability assay. We assessed the probiotic internalization potential of differentiated 3T3-L1 cells by flow cytometry, fluorescence microscopy, and cell lysis method. We determined the lipolytic and anti-adipogenic potential of probiotics by intracellular lipid staining, spectrophotometry, and gene expression analysis. Both probiotics were effective lipolytic agents as revealed by reducing cellular lipids and down-regulation of mammalian adipogenesis marker genes in terminally differentiated 3T3-L1 cells. Previous studies from our group had proven the immune-modulatory properties of these probiotics on an immune-biased mouse model. The present study demonstrates LA and LDB-ST to be effective against adipogenesis. Further in vivo studies will be conducted to strengthen this claim." @default.
- W3157759545 created "2021-05-10" @default.
- W3157759545 creator A5014197315 @default.
- W3157759545 creator A5035244284 @default.
- W3157759545 creator A5086816049 @default.
- W3157759545 date "2021-08-01" @default.
- W3157759545 modified "2023-09-26" @default.
- W3157759545 title "Effects of two potential probiotic Lactobacillus bacteria on adipogenesis in vitro" @default.
- W3157759545 cites W1510986852 @default.
- W3157759545 cites W1520224458 @default.
- W3157759545 cites W1577139444 @default.
- W3157759545 cites W1969703390 @default.
- W3157759545 cites W1976678725 @default.
- W3157759545 cites W1995459393 @default.
- W3157759545 cites W2002789245 @default.
- W3157759545 cites W2012490955 @default.
- W3157759545 cites W2023171333 @default.
- W3157759545 cites W2034997315 @default.
- W3157759545 cites W2046306656 @default.
- W3157759545 cites W2073171519 @default.
- W3157759545 cites W2085673152 @default.
- W3157759545 cites W2097808005 @default.
- W3157759545 cites W2120272765 @default.
- W3157759545 cites W2141902291 @default.
- W3157759545 cites W2147024380 @default.
- W3157759545 cites W2157709517 @default.
- W3157759545 cites W2167081472 @default.
- W3157759545 cites W2170401329 @default.
- W3157759545 cites W2312090344 @default.
- W3157759545 cites W2312331326 @default.
- W3157759545 cites W2314468834 @default.
- W3157759545 cites W2461706302 @default.
- W3157759545 cites W2473078753 @default.
- W3157759545 cites W2601850345 @default.
- W3157759545 cites W2793493516 @default.
- W3157759545 cites W2883459505 @default.
- W3157759545 cites W2888499775 @default.
- W3157759545 cites W2888727853 @default.
- W3157759545 cites W2903107073 @default.
- W3157759545 cites W2905995230 @default.
- W3157759545 cites W2914051326 @default.
- W3157759545 cites W2926683670 @default.
- W3157759545 cites W2936656841 @default.
- W3157759545 cites W2944549000 @default.
- W3157759545 cites W2984669963 @default.
- W3157759545 cites W2994698010 @default.
- W3157759545 cites W3018485802 @default.
- W3157759545 doi "https://doi.org/10.1016/j.lfs.2021.119538" @default.
- W3157759545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33932443" @default.
- W3157759545 hasPublicationYear "2021" @default.
- W3157759545 type Work @default.
- W3157759545 sameAs 3157759545 @default.
- W3157759545 citedByCount "7" @default.
- W3157759545 countsByYear W31577595452021 @default.
- W3157759545 countsByYear W31577595452022 @default.
- W3157759545 countsByYear W31577595452023 @default.
- W3157759545 crossrefType "journal-article" @default.
- W3157759545 hasAuthorship W3157759545A5014197315 @default.
- W3157759545 hasAuthorship W3157759545A5035244284 @default.
- W3157759545 hasAuthorship W3157759545A5086816049 @default.
- W3157759545 hasConcept C100544194 @default.
- W3157759545 hasConcept C122927707 @default.
- W3157759545 hasConcept C142536801 @default.
- W3157759545 hasConcept C1491633281 @default.
- W3157759545 hasConcept C202751555 @default.
- W3157759545 hasConcept C203014093 @default.
- W3157759545 hasConcept C2777221637 @default.
- W3157759545 hasConcept C2777276588 @default.
- W3157759545 hasConcept C2780206646 @default.
- W3157759545 hasConcept C2780255968 @default.
- W3157759545 hasConcept C523546767 @default.
- W3157759545 hasConcept C53227056 @default.
- W3157759545 hasConcept C54355233 @default.
- W3157759545 hasConcept C553184892 @default.
- W3157759545 hasConcept C55493867 @default.
- W3157759545 hasConcept C86803240 @default.
- W3157759545 hasConcept C8891405 @default.
- W3157759545 hasConcept C89423630 @default.
- W3157759545 hasConceptScore W3157759545C100544194 @default.
- W3157759545 hasConceptScore W3157759545C122927707 @default.
- W3157759545 hasConceptScore W3157759545C142536801 @default.
- W3157759545 hasConceptScore W3157759545C1491633281 @default.
- W3157759545 hasConceptScore W3157759545C202751555 @default.
- W3157759545 hasConceptScore W3157759545C203014093 @default.
- W3157759545 hasConceptScore W3157759545C2777221637 @default.
- W3157759545 hasConceptScore W3157759545C2777276588 @default.
- W3157759545 hasConceptScore W3157759545C2780206646 @default.
- W3157759545 hasConceptScore W3157759545C2780255968 @default.
- W3157759545 hasConceptScore W3157759545C523546767 @default.
- W3157759545 hasConceptScore W3157759545C53227056 @default.
- W3157759545 hasConceptScore W3157759545C54355233 @default.
- W3157759545 hasConceptScore W3157759545C553184892 @default.
- W3157759545 hasConceptScore W3157759545C55493867 @default.
- W3157759545 hasConceptScore W3157759545C86803240 @default.
- W3157759545 hasConceptScore W3157759545C8891405 @default.
- W3157759545 hasConceptScore W3157759545C89423630 @default.
- W3157759545 hasFunder F4320320768 @default.
- W3157759545 hasFunder F4320327905 @default.