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- W3157765512 abstract "To evaluate the change of bone mineral density induced by microgravity, eighteen 7-week-old female Spraque-Dawley (SD) rats underwent hindlimb suspension for 2 weeks. After a week of stabilization, rats were randomly divided into three groups: before suspension group (n=6, before), 2-week non suspension control group (n=6, Non) and 2-week hindlimb suspension group (n=6, Sus). All three groups were fed standard lab chow (CRF-1, Charles river, JAPAN) to give the same volume of food to all groups. Before the experimental period and after the 2-week suspension, rats were terminated and femurs were removed for analysis of bone mineral density (BMD) by dual energy X-ray absorptionmetry (DEXA, Lunar DPXL, USA) and peripheral quantitative computed tomography (pQCT, XC-960, Germany). The femoral fresh weight of the Sus group decreased approximately 8 % compared to the Non group (p<.05), but the femoral length showed no difference between the Non and the Sus groups. On the other hand, whole BMD and cortical BMD of the femur in the Non group were increased by approximately 16 % and 4 % respectively compared with those of the before group (p<.001), but those of the Sus group did not increase, and were approximately 11 % and 4 % lower than those of the Non group (p<.01). Similarly, the cortical cross-sectional area, bone thickness and stress-strain index (SSI), which reflect the mechanical strength, of cortical bone in the Non group significantly increased(p<.01, respectively), but those of the Sus group were significantly lower than those of the Non group (p<.01 or p<.001). However, the trabecular BMD did not show a significant difference among all groups. The serum calcium (Ca) concentration, urinary Ca and urinary deoxypyridinoline (Dpd) excretions between the Non and the Sus groups showed similar levels. However, the urinary phosphate (P) excretion of the Sus group dynamically decreased to approximately 50% lower than that of the Non group (p<.05) while serum P concentration increased (p<.001). These results suggest that exposure to the microgravity environment induces spontaneous osteopenia mainly in cortical bone, and this osteopenia might be caused by disturbed P homeostasis." @default.
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- W3157765512 date "2006-01-01" @default.
- W3157765512 modified "2023-09-24" @default.
- W3157765512 title "Changes of Bone Mineral Density after 2-Week Hindlimb Suspension in Rats" @default.
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