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- W3157828509 abstract "Loss of endogenous estrogen and dysregulation of the estrogen receptor signaling pathways are associated with an increase in risk for cognitive deficit and depression in women after menopause. Estrogen therapy for menopause increases the risk of breast and ovarian cancers, and stroke. Therefore, it is critical to find an alternate treatment for menopausal women. Osthole (OST), a coumarin, has been reported to have neuroprotective effects. This study examined whether OST improves ovariectomy (OVX)-induced cognitive impairment, and alleviates anxiety- and depression-like behaviors induced by OVX in mice. Adult female C57BL/6J mice were ovariectomized and then treated with OST at a dose of 30 mg/kg for 14 days. At the end of the treatment period, behavioral tests were used to evaluate spatial learning and memory, recognition memory, anxiety- and depression-like behaviors. A cohort of the mice were sacrificed after 14 days of OST treatment and their hippocampi were collected for measurement of the proteins of interest using western blot. OVX-induced alteration in the levels of proteins was accompanied by cognitive deficit, anxiety- and depression-like behaviors. OST treatment improved cognitive deficit, alleviated anxiety- and depression-like behaviors induced by OVX, and reversed OVX-induced alterations in the levels of synaptic proteins and ERα, BDNF, TrKB, p-CREB, p-Akt and Rac1 in the hippocampus. Therefore, reversal of OVX-induced decrease in the levels of hippocampal proteins by OST might contribute to the effects of OST on improving cognitive deficit and alleviating anxiety- and depression-like behaviors induced by OVX." @default.
- W3157828509 created "2021-05-10" @default.
- W3157828509 creator A5012677271 @default.
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- W3157828509 creator A5031909295 @default.
- W3157828509 creator A5035825572 @default.
- W3157828509 creator A5087879788 @default.
- W3157828509 date "2021-05-06" @default.
- W3157828509 modified "2023-10-16" @default.
- W3157828509 title "Osthole Ameliorates Estrogen Deficiency-Induced Cognitive Impairment in Female Mice" @default.
- W3157828509 cites W1586699954 @default.
- W3157828509 cites W1615902322 @default.
- W3157828509 cites W1640813462 @default.
- W3157828509 cites W1683781550 @default.
- W3157828509 cites W1695897458 @default.
- W3157828509 cites W1881079438 @default.
- W3157828509 cites W1942050486 @default.
- W3157828509 cites W1972383405 @default.
- W3157828509 cites W1972388701 @default.
- W3157828509 cites W1973048800 @default.
- W3157828509 cites W1976441097 @default.
- W3157828509 cites W1983538594 @default.
- W3157828509 cites W1991856249 @default.
- W3157828509 cites W1993056927 @default.
- W3157828509 cites W1995853598 @default.
- W3157828509 cites W1998007696 @default.
- W3157828509 cites W1998113371 @default.
- W3157828509 cites W2005459396 @default.
- W3157828509 cites W2005527030 @default.
- W3157828509 cites W2007269369 @default.
- W3157828509 cites W2018643157 @default.
- W3157828509 cites W2025500109 @default.
- W3157828509 cites W2027610787 @default.
- W3157828509 cites W2034627732 @default.
- W3157828509 cites W2034861130 @default.
- W3157828509 cites W2037611373 @default.
- W3157828509 cites W2041013517 @default.
- W3157828509 cites W2047953158 @default.
- W3157828509 cites W2049104809 @default.
- W3157828509 cites W2057838508 @default.
- W3157828509 cites W2060046054 @default.
- W3157828509 cites W2067446935 @default.
- W3157828509 cites W2068408721 @default.
- W3157828509 cites W2070337983 @default.
- W3157828509 cites W2074725832 @default.
- W3157828509 cites W2081999578 @default.
- W3157828509 cites W2082499181 @default.
- W3157828509 cites W2086578876 @default.
- W3157828509 cites W2086712853 @default.
- W3157828509 cites W2088259542 @default.
- W3157828509 cites W2090058810 @default.
- W3157828509 cites W2095458493 @default.
- W3157828509 cites W2100695238 @default.
- W3157828509 cites W2101741807 @default.
- W3157828509 cites W2114356223 @default.
- W3157828509 cites W2127673211 @default.
- W3157828509 cites W2128453973 @default.
- W3157828509 cites W2135137137 @default.
- W3157828509 cites W2138581472 @default.
- W3157828509 cites W2139059098 @default.
- W3157828509 cites W2143634951 @default.
- W3157828509 cites W2146599264 @default.
- W3157828509 cites W2146993367 @default.
- W3157828509 cites W2154591504 @default.
- W3157828509 cites W2157544511 @default.
- W3157828509 cites W2162934389 @default.
- W3157828509 cites W2163709364 @default.
- W3157828509 cites W2164382301 @default.
- W3157828509 cites W2167318060 @default.
- W3157828509 cites W2175793031 @default.
- W3157828509 cites W2231709936 @default.
- W3157828509 cites W2261240187 @default.
- W3157828509 cites W2324465174 @default.
- W3157828509 cites W2333763415 @default.
- W3157828509 cites W2402031520 @default.
- W3157828509 cites W2403762294 @default.
- W3157828509 cites W2463704048 @default.
- W3157828509 cites W2463822671 @default.
- W3157828509 cites W2551509862 @default.
- W3157828509 cites W2557332265 @default.
- W3157828509 cites W2591693802 @default.
- W3157828509 cites W2744878584 @default.
- W3157828509 cites W2748617320 @default.
- W3157828509 cites W2766643933 @default.
- W3157828509 cites W2769107794 @default.
- W3157828509 cites W2773575211 @default.
- W3157828509 cites W2810669366 @default.
- W3157828509 cites W2901628804 @default.
- W3157828509 cites W2904244708 @default.
- W3157828509 cites W2904863132 @default.
- W3157828509 cites W2907613470 @default.
- W3157828509 cites W2913346441 @default.
- W3157828509 cites W2923945445 @default.
- W3157828509 cites W2952974732 @default.
- W3157828509 cites W2965312042 @default.
- W3157828509 cites W2979750977 @default.
- W3157828509 cites W3002464861 @default.
- W3157828509 cites W3010166601 @default.