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- W3157833042 abstract "Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac condition and the most common cause of sudden cardiac death (SCD) in patients below the age of 35. Genetic testing is a vital part of HCM diagnostics, yet correlation with clinical phenotypes remains complex. Identifying clinical predictors of informative genetic testing may prevent unnecessary investigations and improve cost-effectiveness of services. This article reviews the current literature pertinent to identifying such predictors.Five literature databases were screened using a suitably designed search strategy. Studies investigating the correlation between having a positive genetic test for HCM and a range of clinical and radiological parameters were included in the systematic review.Twenty-nine observational studies of a total of 9,486 patients were included. The main predictors of informative genetic testing were younger age, higher septal thickness, reverse septal curvature, family history of HCM and SCD and the absence of hypertension. Two externally validated scoring systems have also been developed: the Mayo and Toronto scores. Novel imaging markers and complex algorithmic models are emerging predictors.Using clinical predictors to decide whom to test is a feasible alternative to investigating all comers. Nonetheless, currently there is not enough evidence to unequivocally recommend for or against this strategy. Further validation of current predictors and identification of new ones remain open research avenues." @default.
- W3157833042 created "2021-05-10" @default.
- W3157833042 creator A5019984038 @default.
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- W3157833042 creator A5079098596 @default.
- W3157833042 date "2021-05-25" @default.
- W3157833042 modified "2023-10-13" @default.
- W3157833042 title "Clinical prediction of genotypes in hypertrophic cardiomyopathy: A systematic review" @default.
- W3157833042 cites W126979925 @default.
- W3157833042 cites W1566406266 @default.
- W3157833042 cites W1835045179 @default.
- W3157833042 cites W1894212022 @default.
- W3157833042 cites W1970587461 @default.
- W3157833042 cites W1970758820 @default.
- W3157833042 cites W1970913327 @default.
- W3157833042 cites W1975012641 @default.
- W3157833042 cites W1978794954 @default.
- W3157833042 cites W1982206592 @default.
- W3157833042 cites W1988639020 @default.
- W3157833042 cites W1991341849 @default.
- W3157833042 cites W1996275938 @default.
- W3157833042 cites W1997533923 @default.
- W3157833042 cites W1999251970 @default.
- W3157833042 cites W2001283926 @default.
- W3157833042 cites W2007591654 @default.
- W3157833042 cites W2031745977 @default.
- W3157833042 cites W2034904174 @default.
- W3157833042 cites W2036340138 @default.
- W3157833042 cites W2050506350 @default.
- W3157833042 cites W2051967821 @default.
- W3157833042 cites W2051978340 @default.
- W3157833042 cites W2055025344 @default.
- W3157833042 cites W2057003164 @default.
- W3157833042 cites W2057982492 @default.
- W3157833042 cites W2058118262 @default.
- W3157833042 cites W2061302189 @default.
- W3157833042 cites W2061405316 @default.
- W3157833042 cites W2061790077 @default.
- W3157833042 cites W2062419041 @default.
- W3157833042 cites W2067142765 @default.
- W3157833042 cites W2082231490 @default.
- W3157833042 cites W2082794789 @default.
- W3157833042 cites W2089412317 @default.
- W3157833042 cites W2089547093 @default.
- W3157833042 cites W2092825478 @default.
- W3157833042 cites W2097618980 @default.
- W3157833042 cites W2100906399 @default.
- W3157833042 cites W2103641458 @default.
- W3157833042 cites W2103804604 @default.
- W3157833042 cites W2108257604 @default.
- W3157833042 cites W2111366557 @default.
- W3157833042 cites W2117742026 @default.
- W3157833042 cites W2119314695 @default.
- W3157833042 cites W2122587656 @default.
- W3157833042 cites W2127423627 @default.
- W3157833042 cites W2130120331 @default.
- W3157833042 cites W2132058431 @default.
- W3157833042 cites W2132879744 @default.
- W3157833042 cites W2138957821 @default.
- W3157833042 cites W2142803261 @default.
- W3157833042 cites W2145233704 @default.
- W3157833042 cites W2146819040 @default.
- W3157833042 cites W2151462348 @default.
- W3157833042 cites W2152629601 @default.
- W3157833042 cites W2161065160 @default.
- W3157833042 cites W2161106571 @default.
- W3157833042 cites W2164158351 @default.
- W3157833042 cites W2166034602 @default.
- W3157833042 cites W2167730267 @default.
- W3157833042 cites W2167822583 @default.
- W3157833042 cites W2169612678 @default.
- W3157833042 cites W2177870565 @default.
- W3157833042 cites W2283997874 @default.
- W3157833042 cites W2315066195 @default.
- W3157833042 cites W2321606820 @default.
- W3157833042 cites W2350064866 @default.
- W3157833042 cites W2409291013 @default.
- W3157833042 cites W2462450855 @default.
- W3157833042 cites W2549857822 @default.
- W3157833042 cites W2553082274 @default.
- W3157833042 cites W2603701979 @default.
- W3157833042 cites W2613311031 @default.
- W3157833042 cites W2616302857 @default.
- W3157833042 cites W26417677 @default.
- W3157833042 cites W2760819088 @default.
- W3157833042 cites W2762323288 @default.
- W3157833042 cites W2791143601 @default.
- W3157833042 cites W2793178837 @default.
- W3157833042 cites W2795853999 @default.
- W3157833042 cites W2897199670 @default.
- W3157833042 cites W2898130627 @default.
- W3157833042 cites W2904169516 @default.
- W3157833042 cites W2915252786 @default.
- W3157833042 cites W2945166483 @default.
- W3157833042 cites W2963873620 @default.
- W3157833042 cites W2973112759 @default.
- W3157833042 cites W2978515721 @default.