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- W3157863352 abstract "ABSTRACT In natural environments bacteria are frequently exposed to sub-lethal levels of DNA damage which leads to the induction of a stress response (the SOS response in Escherichia coli ). Natural environments also vary in nutrient availability, resulting in distinct physiological changes in bacteria which may have direct implications on their capacity to repair their chromosomes. Here, we evaluated the impact of varying the nutrient availability on the expression of the SOS response induced by chronic sub-lethal DNA damage in E. coli . The expression of the SOS regulon was found to be highly heterogeneous at the single-cell level in all growth conditions. Surprisingly, we observed a larger fraction of high SOS-induced cells in slow growth as compared with fast growth, despite a higher rate of SOS induction in fast growth. This counter-intuitive result can be explained by the dynamic balance between the rate of SOS induction and the division rates of cells exposed to DNA damage. Taken together, our data illustrates how cell division and physiology come together to produce growth-dependent heterogeneity in the DNA damage response." @default.
- W3157863352 created "2021-05-10" @default.
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- W3157863352 date "2021-05-06" @default.
- W3157863352 modified "2023-09-27" @default.
- W3157863352 title "Growth-dependent heterogeneity in the DNA damage response in Escherichia coli" @default.
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- W3157863352 doi "https://doi.org/10.1101/2021.05.06.442821" @default.
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