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- W3157873842 abstract "Objective: Botulinum neurotoxin injection is a commonly used intervention for both cosmetic purposes and movement disorders. Beside retrograde spread of this neurotoxin is known, we aimed to show possible effect of it in some areas in cerebrum by thinking that it may cause significant tractography findings. Background: The involuntary-irregular clonic or tonic movements of the facial muscles that the seventh cranial nerve stimulates are called “Hemifacial Spasm”. Botulinum toxin treatment is the effective treatment of idiopathic hemifacial spasm that is not associated with significant vasculer compression. Design/Methods: We included 30 patients (12 patients: toxin to the right side, 18 patients: toxin to the left side), who were treated with botulinum toxin at least twice on one side of the face. These patients were injected between 2010–2017. On tractography, we identified 4 regions as the motor cortex, centrum semiovale, internal capsule, and exit point from the brain stem of the facial nerve and measured the FA and ADC values of these regions. We compared the FA and ADC values in the regions determined in that patient group, to which side the toxin was injected. Results: There was a significant difference between the values of ADC and FA between right motor cortex and left motor cortex of patients who were treated with botulinum toxin both to the right and to the left. We also found a significant difference in ADC measurements between the right internal capsule and the left internal capsule of patients who treated with toxin to the left. Conclusions: In some animal models, botulinum neurotoxin has been detected in some regions such as the amygdala by retrograde axonal transport. However, in humans the detection of toxin itself can only be demonstrated in postmortem histopathological studies. We think that the toxin can cause loss of function in neurons so this can be demonstrated by tractography. Disclosure: Dr. Cavus has nothing to disclose. Dr. Iseri has nothing to disclose." @default.
- W3157873842 created "2021-05-10" @default.
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- W3157873842 date "2018-04-10" @default.
- W3157873842 modified "2023-10-01" @default.
- W3157873842 title "Evaluation of DTI-Tractography Findings in Botulinum Neurotoxin Injected Hemifacial Spasm Patients (P5.058)" @default.
- W3157873842 hasPublicationYear "2018" @default.
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