FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157896109> ?p ?o ?g. }

• W3157896109 endingPage "288" @default.
• W3157896109 startingPage "281" @default.
• W3157896109 abstract "We aimed to evaluate clinicopathological data in high-risk early-stage cervical cancer and to define the prognostic factors determining the oncological outcomes. This retrospective study included 158 patients with stage IB-IIA cervical cancer who underwent radical hysterectomy plus lymph node dissection. Each patient had at least one high-risk factor. The median tumour diameter of the study group was 30 mm (range, 6-80). Seventy-five (47.5%) patients had parametrial invasion, 32 (20.3%) had positive surgical margins, and 108 (68.4%) had lymph node metastasis. The median duration of follow-up was 42 months (range, 1-228). During this period, 28 patients developed recurrence, and the recurrent disease occurred in a distant area in 18 patients. Five-year disease-free survival was 77.5%, and five-year disease-specific survival was 85%. In multivariate analysis, adjuvant radiotherapy was identified as an independent prognostic factor for recurrence and death. The recurrence (Odds ratio: 10.139, 95% CI: 1.477-69.590, p = .018) and mortality rates (Odds ratio: 16.485, 95% CI: 2.484-109.408, p =.004) were higher in patients who did not receive adjuvant therapy.IMPACT STATEMENTWhat is already known on this subject? The decision to proceed with adjuvant therapy in the patients with early-stage disease treated with surgery depends on the presence of risk factors in pathological examination. Various prognostic factors have been identified in cervical cancer (CC). However, there is a limited number of studies describing the prognostic factors in early-stage CC with high-risk factors.What do the results of this study add? In current study, the recurrence and mortality rates were higher in patients who did not receive adjuvant therapy. No relationship was found between the survival outcomes and the number of high-risk factors. Most of the patients who developed recurrence had the recurrence in the distant localisation. This result questioned the adequacy of adjuvant therapy.What are the implications of these findings for clinical practice and/or further research? There is still a debate over the prognostic factors and the adjuvant treatment options in the patients with early-stage cervical cancer who possess high-risk factors. Adjuvant RT or adjuvant concomitant chemoradiotherapy must definitely be used in this patients. However, adjuvant therapy fails approximately 14-32%, thus multimodal treatment modalities must be developed to improve the recurrence rates and the survival." @default.
• W3157896109 created "2021-05-10" @default.
• W3157896109 creator A5008777634 @default.
• W3157896109 creator A5011317188 @default.
• W3157896109 creator A5027234483 @default.
• W3157896109 creator A5030513274 @default.
• W3157896109 creator A5034119558 @default.
• W3157896109 creator A5048902987 @default.
• W3157896109 creator A5049076699 @default.
• W3157896109 creator A5066835518 @default.
• W3157896109 creator A5078728463 @default.
• W3157896109 date "2021-05-02" @default.
• W3157896109 modified "2023-10-16" @default.
• W3157896109 title "Analysis of the prognostic factors determining the oncological outcomes in patients with high-risk early-stage cervical cancer" @default.
• W3157896109 cites W1992959048 @default.
• W3157896109 cites W2013896394 @default.
• W3157896109 cites W2070789376 @default.
• W3157896109 cites W2111166863 @default.
• W3157896109 cites W2133564026 @default.
• W3157896109 cites W2157719711 @default.
• W3157896109 cites W2170278940 @default.
• W3157896109 cites W2231097422 @default.
• W3157896109 cites W2553088533 @default.
• W3157896109 cites W2586650763 @default.
• W3157896109 cites W2607947734 @default.
• W3157896109 cites W2614507491 @default.
• W3157896109 cites W2889646458 @default.
• W3157896109 cites W2952695966 @default.
• W3157896109 cites W2982376680 @default.
• W3157896109 cites W2991641974 @default.
• W3157896109 cites W3023673754 @default.
• W3157896109 cites W3203488151 @default.
• W3157896109 cites W4211097225 @default.
• W3157896109 cites W4229610456 @default.
• W3157896109 doi "https://doi.org/10.1080/01443615.2021.1882974" @default.
• W3157896109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33938363" @default.
• W3157896109 hasPublicationYear "2021" @default.
• W3157896109 type Work @default.
• W3157896109 sameAs 3157896109 @default.
• W3157896109 citedByCount "3" @default.
• W3157896109 countsByYear W31578961092022 @default.
• W3157896109 countsByYear W31578961092023 @default.
• W3157896109 crossrefType "journal-article" @default.
• W3157896109 hasAuthorship W3157896109A5008777634 @default.
• W3157896109 hasAuthorship W3157896109A5011317188 @default.
• W3157896109 hasAuthorship W3157896109A5027234483 @default.
• W3157896109 hasAuthorship W3157896109A5030513274 @default.
• W3157896109 hasAuthorship W3157896109A5034119558 @default.
• W3157896109 hasAuthorship W3157896109A5048902987 @default.
• W3157896109 hasAuthorship W3157896109A5049076699 @default.
• W3157896109 hasAuthorship W3157896109A5066835518 @default.
• W3157896109 hasAuthorship W3157896109A5078728463 @default.
• W3157896109 hasConcept C121608353 @default.
• W3157896109 hasConcept C126322002 @default.
• W3157896109 hasConcept C141071460 @default.
• W3157896109 hasConcept C143998085 @default.
• W3157896109 hasConcept C146357865 @default.
• W3157896109 hasConcept C151730666 @default.
• W3157896109 hasConcept C156957248 @default.
• W3157896109 hasConcept C167135981 @default.
• W3157896109 hasConcept C2777982462 @default.
• W3157896109 hasConcept C2778220009 @default.
• W3157896109 hasConcept C2779134260 @default.
• W3157896109 hasConcept C2779494336 @default.
• W3157896109 hasConcept C2780849966 @default.
• W3157896109 hasConcept C38180746 @default.
• W3157896109 hasConcept C50440223 @default.
• W3157896109 hasConcept C509974204 @default.
• W3157896109 hasConcept C71924100 @default.
• W3157896109 hasConcept C86803240 @default.
• W3157896109 hasConceptScore W3157896109C121608353 @default.
• W3157896109 hasConceptScore W3157896109C126322002 @default.
• W3157896109 hasConceptScore W3157896109C141071460 @default.
• W3157896109 hasConceptScore W3157896109C143998085 @default.
• W3157896109 hasConceptScore W3157896109C146357865 @default.
• W3157896109 hasConceptScore W3157896109C151730666 @default.
• W3157896109 hasConceptScore W3157896109C156957248 @default.
• W3157896109 hasConceptScore W3157896109C167135981 @default.
• W3157896109 hasConceptScore W3157896109C2777982462 @default.
• W3157896109 hasConceptScore W3157896109C2778220009 @default.
• W3157896109 hasConceptScore W3157896109C2779134260 @default.
• W3157896109 hasConceptScore W3157896109C2779494336 @default.
• W3157896109 hasConceptScore W3157896109C2780849966 @default.
• W3157896109 hasConceptScore W3157896109C38180746 @default.
• W3157896109 hasConceptScore W3157896109C50440223 @default.
• W3157896109 hasConceptScore W3157896109C509974204 @default.
• W3157896109 hasConceptScore W3157896109C71924100 @default.
• W3157896109 hasConceptScore W3157896109C86803240 @default.
• W3157896109 hasIssue "2" @default.
• W3157896109 hasLocation W31578961091 @default.
• W3157896109 hasLocation W31578961092 @default.
• W3157896109 hasOpenAccess W3157896109 @default.
• W3157896109 hasPrimaryLocation W31578961091 @default.
• W3157896109 hasRelatedWork W1998801365 @default.
• W3157896109 hasRelatedWork W2009137688 @default.
• W3157896109 hasRelatedWork W2382269822 @default.
• W3157896109 hasRelatedWork W2384708512 @default.
• W3157896109 hasRelatedWork W2404402449 @default.

• next