Matches in SemOpenAlex for { <https://semopenalex.org/work/W315795514> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W315795514 abstract "This thesis describes the examination and development of cationic iron carbonyl complexes for use in parallel synthesis both in solution phase and on solid phase. A solution phase methodology for carbon-carbon and carbon-heteroatom formation, utilizing polymer bound reagents and scavengers and amenable for automation has been successfully developed. Ten different nucleophiles (carbon, nitrogen, oxygen, and sulfur) were used, giving the targeted cyclohexadienoic amides in good yields and excellent purities. The solution phase methodology was transferred to a solid phase protocol, generating a diverse set of eighteen cyclohexadienoic amides of excellent purities and in good yields using nine different nucleophiles (carbon, nitrogen, oxygen, and phosphorous). Both methods use the same reaction conditions for all nucleophiles demonstrating the versatility of these methods in generating compound libraries of high diversity. Even sterically hindered nucleophiles like tert-butanol gave good results. Activated esters were also investigated as potential linkers for iron carbonyl mediated chemistry on solid phase, and a tetrafluorophenol linkage was found to be the most suitable for this purpose. Synthesis of oseltamivir analogues and galectin inhibitors based on cationic iron carbonyl chemistry has been undertaken and work is currently in progress to finalize these projects. This thesis also describes the investigation of a phosphate based linker for cationic iron carbonyl chemistry on solid phase. In solution phase, palladium and nickel catalyzed cross-coupling reaction cleaved the investigated enyl and dienyl phosphates to give the targeted olefins. However, when transferring to a solid phase protocol only traces of the desired olefin were detected. In summary, this thesis shows that cationic iron carbonyl chemistry is amenable for parallel synthesis both in solution and on solid phase using the same reaction conditions for a wide range of nucleophiles.Keywords: solid phase, parallel synthesis, scavenger, polymer bound reagent, iron carbonyl complex, cation, dienyl, active ester, linker, oseltamivir, galectin inhibitor" @default.
- W315795514 created "2016-06-24" @default.
- W315795514 creator A5072308039 @default.
- W315795514 date "2005-01-01" @default.
- W315795514 modified "2023-09-27" @default.
- W315795514 title "Iron Carbonyl Mediated Parallel Synthesis" @default.
- W315795514 hasPublicationYear "2005" @default.
- W315795514 type Work @default.
- W315795514 sameAs 315795514 @default.
- W315795514 citedByCount "0" @default.
- W315795514 crossrefType "journal-article" @default.
- W315795514 hasAuthorship W315795514A5072308039 @default.
- W315795514 hasConcept C161790260 @default.
- W315795514 hasConcept C178790620 @default.
- W315795514 hasConcept C178907741 @default.
- W315795514 hasConcept C183882617 @default.
- W315795514 hasConcept C185592680 @default.
- W315795514 hasConcept C21951064 @default.
- W315795514 hasConcept C2776469878 @default.
- W315795514 hasConcept C2779281246 @default.
- W315795514 hasConcept C40875361 @default.
- W315795514 hasConcept C55493867 @default.
- W315795514 hasConceptScore W315795514C161790260 @default.
- W315795514 hasConceptScore W315795514C178790620 @default.
- W315795514 hasConceptScore W315795514C178907741 @default.
- W315795514 hasConceptScore W315795514C183882617 @default.
- W315795514 hasConceptScore W315795514C185592680 @default.
- W315795514 hasConceptScore W315795514C21951064 @default.
- W315795514 hasConceptScore W315795514C2776469878 @default.
- W315795514 hasConceptScore W315795514C2779281246 @default.
- W315795514 hasConceptScore W315795514C40875361 @default.
- W315795514 hasConceptScore W315795514C55493867 @default.
- W315795514 hasLocation W3157955141 @default.
- W315795514 hasOpenAccess W315795514 @default.
- W315795514 hasPrimaryLocation W3157955141 @default.
- W315795514 hasRelatedWork W1537273074 @default.
- W315795514 hasRelatedWork W1991747356 @default.
- W315795514 hasRelatedWork W1993291615 @default.
- W315795514 hasRelatedWork W2061286090 @default.
- W315795514 hasRelatedWork W2071023824 @default.
- W315795514 hasRelatedWork W2089909750 @default.
- W315795514 hasRelatedWork W2315731970 @default.
- W315795514 hasRelatedWork W2340633478 @default.
- W315795514 hasRelatedWork W2588312318 @default.
- W315795514 hasRelatedWork W2821679422 @default.
- W315795514 hasRelatedWork W2889325659 @default.
- W315795514 hasRelatedWork W2949709218 @default.
- W315795514 hasRelatedWork W2952015628 @default.
- W315795514 hasRelatedWork W2952077507 @default.
- W315795514 hasRelatedWork W2999194351 @default.
- W315795514 hasRelatedWork W3014271955 @default.
- W315795514 hasRelatedWork W3023221859 @default.
- W315795514 hasRelatedWork W3204385238 @default.
- W315795514 hasRelatedWork W2873221091 @default.
- W315795514 hasRelatedWork W60670888 @default.
- W315795514 isParatext "false" @default.
- W315795514 isRetracted "false" @default.
- W315795514 magId "315795514" @default.
- W315795514 workType "article" @default.