Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157970390> ?p ?o ?g. }
- W3157970390 endingPage "1844" @default.
- W3157970390 startingPage "1827" @default.
- W3157970390 abstract "Sepsis is not only a threat to the health of individual patients but also presents a serious epidemiological problem. Despite intensive research, modern sepsis therapy remains based primarily on antimicrobial treatment and supporting the functions of failing organs. Finding a cure for sepsis represents a great and as yet unfulfilled need in modern medicine. Research results indicate that the activity of poly (adenosine diphosphate (ADP)-ribose) polymerase (PARP) may play an important role in the inflammatory response and the cellular metabolic disorders found in sepsis. Mechanisms by which PARP-1 may contribute to inflammation and metabolic disorders include effects on the regulation of gene expression, impaired metabolism, cell death, and the release of alarmins. These findings suggest that inhibition of this enzyme may be a promising solution for the treatment of sepsis. In studies using experimental sepsis models, inhibition of PARP-1 has been shown to ameliorate the inflammatory response and increase survival. This action was described, among others, for olaparib, a PARP-1 inhibitor approved for use in oncology. While the results of current research are promising, the use of PARP inhibitors in non-oncological diseases raises some concerns, mainly related to the enzyme's role in deoxyribonucleic acid (DNA) repair. However, the results of studies on experimental models indicate the effectiveness of even short-term PARP-1 inhibition and do not confirm concerns regarding its impact on the integrity of nuclear DNA. Current research presents PARP inhibition as a potential solution for the treatment of sepsis and indicates the need for further research." @default.
- W3157970390 created "2021-05-10" @default.
- W3157970390 creator A5008794762 @default.
- W3157970390 creator A5047066944 @default.
- W3157970390 date "2021-05-01" @default.
- W3157970390 modified "2023-10-12" @default.
- W3157970390 title "PARP Inhibitors: An Innovative Approach to the Treatment of Inflammation and Metabolic Disorders in Sepsis" @default.
- W3157970390 cites W1045337831 @default.
- W3157970390 cites W111533048 @default.
- W3157970390 cites W1155980999 @default.
- W3157970390 cites W1504661786 @default.
- W3157970390 cites W1532907366 @default.
- W3157970390 cites W1544387209 @default.
- W3157970390 cites W1549011458 @default.
- W3157970390 cites W1590874748 @default.
- W3157970390 cites W1600317768 @default.
- W3157970390 cites W1965424729 @default.
- W3157970390 cites W1966928113 @default.
- W3157970390 cites W1971745781 @default.
- W3157970390 cites W1973268287 @default.
- W3157970390 cites W1991742606 @default.
- W3157970390 cites W1992397774 @default.
- W3157970390 cites W1998596873 @default.
- W3157970390 cites W2003100658 @default.
- W3157970390 cites W2003165179 @default.
- W3157970390 cites W2005458257 @default.
- W3157970390 cites W2005749687 @default.
- W3157970390 cites W2009007206 @default.
- W3157970390 cites W2012464463 @default.
- W3157970390 cites W2013969500 @default.
- W3157970390 cites W2020291026 @default.
- W3157970390 cites W2020304127 @default.
- W3157970390 cites W2024276071 @default.
- W3157970390 cites W2029068688 @default.
- W3157970390 cites W2029108569 @default.
- W3157970390 cites W2030350861 @default.
- W3157970390 cites W2035098081 @default.
- W3157970390 cites W2038131926 @default.
- W3157970390 cites W2039171346 @default.
- W3157970390 cites W2040026049 @default.
- W3157970390 cites W2044390268 @default.
- W3157970390 cites W2044733823 @default.
- W3157970390 cites W2049028195 @default.
- W3157970390 cites W2049927822 @default.
- W3157970390 cites W2051063130 @default.
- W3157970390 cites W2054938569 @default.
- W3157970390 cites W2058058143 @default.
- W3157970390 cites W2062422180 @default.
- W3157970390 cites W2064830796 @default.
- W3157970390 cites W2065139599 @default.
- W3157970390 cites W2066204526 @default.
- W3157970390 cites W2068887701 @default.
- W3157970390 cites W2071034808 @default.
- W3157970390 cites W2077559325 @default.
- W3157970390 cites W2079493147 @default.
- W3157970390 cites W2082231023 @default.
- W3157970390 cites W2085215116 @default.
- W3157970390 cites W2086038769 @default.
- W3157970390 cites W2086531857 @default.
- W3157970390 cites W2089549004 @default.
- W3157970390 cites W2094916265 @default.
- W3157970390 cites W2095061901 @default.
- W3157970390 cites W2099904057 @default.
- W3157970390 cites W2101114817 @default.
- W3157970390 cites W2104035332 @default.
- W3157970390 cites W2104519081 @default.
- W3157970390 cites W2106059513 @default.
- W3157970390 cites W2109690762 @default.
- W3157970390 cites W2109900910 @default.
- W3157970390 cites W2113699634 @default.
- W3157970390 cites W2118542406 @default.
- W3157970390 cites W2133629433 @default.
- W3157970390 cites W2133798481 @default.
- W3157970390 cites W2135364719 @default.
- W3157970390 cites W2136708412 @default.
- W3157970390 cites W2144269215 @default.
- W3157970390 cites W2145889332 @default.
- W3157970390 cites W2146528609 @default.
- W3157970390 cites W2148430259 @default.
- W3157970390 cites W2153053799 @default.
- W3157970390 cites W2153426648 @default.
- W3157970390 cites W2161933230 @default.
- W3157970390 cites W2162460329 @default.
- W3157970390 cites W2163846356 @default.
- W3157970390 cites W2167712347 @default.
- W3157970390 cites W2171972386 @default.
- W3157970390 cites W2183384385 @default.
- W3157970390 cites W2267910177 @default.
- W3157970390 cites W2280404143 @default.
- W3157970390 cites W2303885862 @default.
- W3157970390 cites W2343392360 @default.
- W3157970390 cites W2415024807 @default.
- W3157970390 cites W2521759723 @default.
- W3157970390 cites W2522862081 @default.
- W3157970390 cites W2529207804 @default.
- W3157970390 cites W2540412673 @default.
- W3157970390 cites W2540759005 @default.
- W3157970390 cites W2588135595 @default.