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- W3157973676 endingPage "833" @default.
- W3157973676 startingPage "833" @default.
- W3157973676 abstract "Hepatitis C virus (HCV) is a serious and growing public health problem despite recent developments of antiviral therapeutics. To achieve global elimination of HCV, an effective cross-genotype vaccine is needed. The failure of previous vaccination trials to elicit an effective cross-reactive immune response demands better vaccine antigens to induce a potent cross-neutralizing response to improve vaccine efficacy. HCV E1 and E2 envelope (Env) glycoproteins are the main targets for neutralizing antibodies (nAbs), which aid in HCV clearance and protection. Therefore, a molecular-level understanding of the nAb responses against HCV is imperative for the rational design of cross-genotype vaccine antigens. Here we summarize the recent advances in structural studies of HCV Env and Env-nAb complexes and how they improve our understanding of immune recognition of HCV. We review the structural data defining HCV neutralization epitopes and conformational plasticity of the Env proteins, and the knowledge applicable to rational vaccine design." @default.
- W3157973676 created "2021-05-10" @default.
- W3157973676 creator A5003516934 @default.
- W3157973676 creator A5088455765 @default.
- W3157973676 creator A5089429782 @default.
- W3157973676 date "2021-05-04" @default.
- W3157973676 modified "2023-10-16" @default.
- W3157973676 title "From Structural Studies to HCV Vaccine Design" @default.
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