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- W3157976075 abstract "A complete PIC-Mediator structure As a critical transcription coactivator, the multisubunit Mediator complex binds RNA polymerase II (Pol II), facilitates preinitiation complex (PIC) assembly, and stimulates transcription and phosphorylation of the Pol II C-terminal domain (CTD). However, how these critical transcriptional events are coordinated by Mediator is not fully understood. Chen et al. determined the structures of human Mediator and Mediator-bound PIC in distinct conformational states, the latter of which represents a complete PIC-Mediator complex assembled on the 14-subunit transcription factor IID (TFIID). The structures show that Mediator undergoes reorganization during PIC-Mediator assembly, sandwiches and facilitates phosphorylation of Pol II CTD, and works with TFIID to organize TFIIH in PIC for transcription initiation. Science , abg0635, this issue p. eabg0635" @default.
- W3157976075 created "2021-05-10" @default.
- W3157976075 creator A5006716123 @default.
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- W3157976075 creator A5062270392 @default.
- W3157976075 creator A5078983945 @default.
- W3157976075 date "2021-06-04" @default.
- W3157976075 modified "2023-10-12" @default.
- W3157976075 title "Structures of the human Mediator and Mediator-bound preinitiation complex" @default.
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