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- W3157995342 abstract "Summary Antigen classes other than proteins can be presented to T cells by near-monomorphic antigen-presenting molecules such as CD1, MR1, and butyrophilin 3A1. We sought to define the roles of donor unrestricted T (DURT) cells, including MR1-reactive MAIT cells, CD1b-reactive glucose monomycolate (GMM)-specific T cells, CD1d-reactive NKT cells, and γδ T cells, in vaccination against Mycobacterium tuberculosis . We characterized DURT cells following primary bacille Calmette-Guerin (BCG) vaccination in infants or BCG-revaccination in adults. BCG (re)vaccination did not modulate peripheral blood frequencies, T cell activation or memory profiles of MAIT cells, CD1b-restricted GMM-specific and germline-encoded mycolyl-reactive (GEM) cells or CD1d- restricted NKT cells. By contrast, BCG vaccination was associated with increased frequencies of γδ T cells as well as a novel subset of IFN-γ-expressing CD4 + T cells with a CD26 + CD161 + TRAV1-2 − phenotype in infants. More studies are required to understand the full potential of DURT cells in new TB vaccine strategies." @default.
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- W3157995342 date "2021-04-29" @default.
- W3157995342 modified "2023-09-25" @default.
- W3157995342 title "Effects of BCG vaccination on donor unrestricted T cells in humans" @default.
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- W3157995342 doi "https://doi.org/10.1101/2021.04.29.441927" @default.
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