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- W3157996975 abstract "Interstitial lung disease (ILD) is a cause of substantial morbidity and mortality amongst autoimmune diseases, including myositis. Despite first-line therapy with immunosuppression, many inflammatory ILDs advance to a fibrotic stage. In such patients, progressive fibrosis may be amenable to treatment with antifibrotic medications, which were initially studied and approved for the treatment of idiopathic pulmonary fibrosis. We here review the available data that support the use of antifibrotics in connective tissue diseases and progressive fibrosing ILDs. There is now a growing body of evidence in both large randomized clinical trials and on the evolving pathophysiologic pathways to support the use of antifibrotics in select patients with autoimmune ILD and a fibrotic phenotype. Further study of antifibrotics in combination with immunosuppressive medications, and in the myositis-ILD population, is needed." @default.
- W3157996975 created "2021-05-10" @default.
- W3157996975 creator A5004112494 @default.
- W3157996975 creator A5017683410 @default.
- W3157996975 date "2021-01-01" @default.
- W3157996975 modified "2023-10-18" @default.
- W3157996975 title "Antifibrotic Therapy: Is There a Role in Myositis-Interstitial Lung Disease?" @default.
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- W3157996975 doi "https://doi.org/10.1159/000515607" @default.
- W3157996975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33951665" @default.
- W3157996975 hasPublicationYear "2021" @default.
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