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- W3158050678 abstract "Abstract Background Patch angioplasty in conventional carotid endarterectomy is suggested to reduce the risk of restenosis and recurrent ipsilateral stroke compared with primary closure. A systematic review of randomized clinical trials is needed to compare outcomes (benefits and harms) of both techniques. Methods Searches (CENTRAL, PubMed/MEDLINE, EMBASE, and other databases) were last updated 3rd of January 2021. We included randomized clinical trials comparing carotid endarterectomy with patch angioplasty versus primary closure of the arterial wall in patients with a symptomatic and significant (> 50%) carotid stenosis. Primary outcomes are defined as all-cause mortality and serious adverse events. Results We included 12 randomized clinical trials including 2187 participants who underwent 2335 operations for carotid stenosis comparing carotid endarterectomy with patch closure (1280 operations) versus carotid endarterectomy with primary closure (1055 operations). Meta-analysis comparing carotid endarterectomy with patch angioplasty versus carotid endarterectomy with primary closure may potentially decrease the number of patients with all-cause mortality (RR 0.53; 95% CI 0.26 to 1.08; p = 0.08, best-case scenario for patch), serious adverse events (RR 0.73; 95% CI 0.56 to 0.96; p = 0.02, best-case scenario for patch), and the number of restenosis (RR 0.41; 95% CI 0.23 to 0.71; p < 0.01). Trial sequential analysis demonstrated that the required information sizes were far from being reached for these patient-important outcomes. All the patient-relevant outcomes were at low certainty of evidence according to The Grading of Recommendations Assessment, Development, and Evaluation. Conclusions This systematic review showed no conclusive evidence of a difference between carotid endarterectomy with patch angioplasty versus primary closure of the arterial wall on all-cause mortality, < 30 days mortality, < 30 days stroke, or any other serious adverse events. These conclusions are based on data from 15 to 35 years ago, obtained in trials with very low certainty according to GRADE, and should be interpreted cautiously. Therefore, we suggest conducting new randomized clinical trials patch angioplasty versus primary closure in carotid endarterectomy in symptomatic patients with an internal carotid artery stenosis of 50% or more. Such trials ought to be designed according to the Standard Protocol Items: Recommendations for Interventional Trials statement (Chan et al., Ann Intern Med 1:200–7, 2013) and reported according to the Consolidated Standards of Reporting Trials statement (Schulz et al., 7, 2010). Until conclusive evidence is obtained, the standard of care according to guidelines should not be abandoned. Systematic review registration PROSPERO CRD42014013416 . Review protocol publication 2019 DOI: 10.1136/bmjopen-2018-026419 ." @default.
- W3158050678 created "2021-05-10" @default.
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- W3158050678 date "2021-05-06" @default.
- W3158050678 modified "2023-09-27" @default.
- W3158050678 title "Carotid endarterectomy with patch angioplasty versus primary closure in patients with symptomatic and significant stenosis: a systematic review with meta-analyses and trial sequential analysis of randomized clinical trials" @default.
- W3158050678 cites W1500364488 @default.
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- W3158050678 cites W1964502734 @default.
- W3158050678 cites W1965276911 @default.
- W3158050678 cites W1971441597 @default.
- W3158050678 cites W1971941296 @default.
- W3158050678 cites W1982425177 @default.
- W3158050678 cites W1999536155 @default.
- W3158050678 cites W2004198253 @default.
- W3158050678 cites W2006793312 @default.
- W3158050678 cites W2007911452 @default.
- W3158050678 cites W2015606468 @default.
- W3158050678 cites W2036397809 @default.
- W3158050678 cites W2040094554 @default.
- W3158050678 cites W2041594772 @default.
- W3158050678 cites W2050793747 @default.
- W3158050678 cites W2059057999 @default.
- W3158050678 cites W2059305596 @default.
- W3158050678 cites W2064240517 @default.
- W3158050678 cites W2065384164 @default.
- W3158050678 cites W2066339175 @default.
- W3158050678 cites W2067873814 @default.
- W3158050678 cites W2069396906 @default.
- W3158050678 cites W2070788648 @default.
- W3158050678 cites W2076635340 @default.
- W3158050678 cites W2076717543 @default.
- W3158050678 cites W2077785232 @default.
- W3158050678 cites W2090132603 @default.
- W3158050678 cites W2100194095 @default.
- W3158050678 cites W2105125840 @default.
- W3158050678 cites W2115649050 @default.
- W3158050678 cites W2115836576 @default.
- W3158050678 cites W2121080053 @default.
- W3158050678 cites W2127288185 @default.
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- W3158050678 cites W2745403241 @default.
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- W3158050678 cites W2945508931 @default.
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- W3158050678 cites W4293858969 @default.
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- W3158050678 doi "https://doi.org/10.1186/s13643-021-01692-8" @default.
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