Matches in SemOpenAlex for { <https://semopenalex.org/work/W3158121010> ?p ?o ?g. }
- W3158121010 abstract "Rac1 GTPase is hyperactivated in tumors and contributes to malignancy. Rac1 disruption of junctions requires its effector PAK1, but the precise mechanisms are unknown. Here, we show that E-cadherin is internalized via micropinocytosis in a PAK1-dependent manner without catenin dissociation and degradation. In addition to internalization, PAK1 regulates E-cadherin transport by fine-tuning Rab small GTPase function. PAK1 phosphorylates a core Rab regulator, RabGDIβ, but not RabGDIα. Phosphorylated RabGDIβ preferentially associates with Rab5 and Rab11, which is predicted to promote Rab retrieval from membranes. Consistent with this hypothesis, Rab11 is activated by Rac1, and inhibition of Rab11 function partially rescues E-cadherin destabilization. Thus, Rac1 activation reduces surface cadherin levels as a net result of higher bulk flow of membrane uptake that counteracts Rab11-dependent E-cadherin delivery to junctions (recycling and/or exocytosis). This unique small GTPase crosstalk has an impact on Rac1 and PAK1 regulation of membrane remodeling during epithelial dedifferentiation, adhesion, and motility." @default.
- W3158121010 created "2021-05-10" @default.
- W3158121010 creator A5025268046 @default.
- W3158121010 creator A5032870651 @default.
- W3158121010 creator A5041786792 @default.
- W3158121010 creator A5056769047 @default.
- W3158121010 creator A5056942804 @default.
- W3158121010 creator A5073700548 @default.
- W3158121010 creator A5086674978 @default.
- W3158121010 date "2021-04-29" @default.
- W3158121010 modified "2023-10-02" @default.
- W3158121010 title "Rac1-PAK1 regulation of Rab11 cycling promotes junction destabilization" @default.
- W3158121010 cites W1510534561 @default.
- W3158121010 cites W1515918463 @default.
- W3158121010 cites W1761391800 @default.
- W3158121010 cites W1963848219 @default.
- W3158121010 cites W1964802617 @default.
- W3158121010 cites W1969292147 @default.
- W3158121010 cites W1973186763 @default.
- W3158121010 cites W1974375550 @default.
- W3158121010 cites W1975844164 @default.
- W3158121010 cites W1975912195 @default.
- W3158121010 cites W1982194496 @default.
- W3158121010 cites W1982807692 @default.
- W3158121010 cites W1986263736 @default.
- W3158121010 cites W1989173642 @default.
- W3158121010 cites W1991379362 @default.
- W3158121010 cites W1994668150 @default.
- W3158121010 cites W1998745222 @default.
- W3158121010 cites W2000682166 @default.
- W3158121010 cites W2003569663 @default.
- W3158121010 cites W2011247549 @default.
- W3158121010 cites W2011463708 @default.
- W3158121010 cites W2012212081 @default.
- W3158121010 cites W2012213189 @default.
- W3158121010 cites W2014304886 @default.
- W3158121010 cites W2024309614 @default.
- W3158121010 cites W2024406870 @default.
- W3158121010 cites W2031999218 @default.
- W3158121010 cites W2035000040 @default.
- W3158121010 cites W2038200378 @default.
- W3158121010 cites W2042560536 @default.
- W3158121010 cites W2045616300 @default.
- W3158121010 cites W2046031332 @default.
- W3158121010 cites W2046203977 @default.
- W3158121010 cites W2046356479 @default.
- W3158121010 cites W2047383250 @default.
- W3158121010 cites W2053629739 @default.
- W3158121010 cites W2060620637 @default.
- W3158121010 cites W2065168490 @default.
- W3158121010 cites W2069031003 @default.
- W3158121010 cites W2072204570 @default.
- W3158121010 cites W2074018262 @default.
- W3158121010 cites W2081653982 @default.
- W3158121010 cites W2085126643 @default.
- W3158121010 cites W2088484514 @default.
- W3158121010 cites W2090347885 @default.
- W3158121010 cites W2091844216 @default.
- W3158121010 cites W2093079184 @default.
- W3158121010 cites W2099674410 @default.
- W3158121010 cites W2102391005 @default.
- W3158121010 cites W2104982744 @default.
- W3158121010 cites W2111964892 @default.
- W3158121010 cites W2115373693 @default.
- W3158121010 cites W2119507882 @default.
- W3158121010 cites W2120274506 @default.
- W3158121010 cites W2121764741 @default.
- W3158121010 cites W2127186963 @default.
- W3158121010 cites W2127488207 @default.
- W3158121010 cites W2133500171 @default.
- W3158121010 cites W2137710360 @default.
- W3158121010 cites W2142793416 @default.
- W3158121010 cites W2143021779 @default.
- W3158121010 cites W2143111492 @default.
- W3158121010 cites W2143306763 @default.
- W3158121010 cites W2149491013 @default.
- W3158121010 cites W2153561951 @default.
- W3158121010 cites W2162208736 @default.
- W3158121010 cites W2162669567 @default.
- W3158121010 cites W2163065284 @default.
- W3158121010 cites W2164378264 @default.
- W3158121010 cites W2168327607 @default.
- W3158121010 cites W2169019804 @default.
- W3158121010 cites W2195195116 @default.
- W3158121010 cites W2213327126 @default.
- W3158121010 cites W2217009009 @default.
- W3158121010 cites W2253950023 @default.
- W3158121010 cites W2284522937 @default.
- W3158121010 cites W2295615914 @default.
- W3158121010 cites W2340039096 @default.
- W3158121010 cites W2342189534 @default.
- W3158121010 cites W2346515103 @default.
- W3158121010 cites W2509108665 @default.
- W3158121010 cites W2510386957 @default.
- W3158121010 cites W2516462945 @default.
- W3158121010 cites W2550012448 @default.
- W3158121010 cites W2562685286 @default.
- W3158121010 cites W2590161731 @default.
- W3158121010 cites W2594292083 @default.
- W3158121010 cites W2605050302 @default.