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• W3158210316 abstract "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the coronavirus disease 2019 (COVID-19). The World Health Organization (WHO) has announced that COVID-19 is a pandemic having a higher spread rate rather than the mortality. Identification of a potential approach or therapy against COVID-19 is still under consideration. Therefore, it is essential to have an insight into SARS-CoV-2, its interacting partner, and domains for an effective treatment. The present study is divided into three main categories, including SARS-CoV-2 prominent receptor and its expression levels, other interacting partners, and their binding domains. The first section focuses primarily on coronaviruses' general aspects (SARS-CoV-2, SARS-CoV, and the Middle East Respiratory Syndrome Coronaviruses (MERS-CoV)) their structures, similarities, and mode of infections. The second section discusses the host receptors which includes the human targets of coronaviruses like dipeptidyl peptidase 4 (DPP4), CD147, CD209L, Angiotensin-Converting Enzyme 2 (ACE2), and other miscellaneous targets (type-II transmembrane serine proteases (TTSPs), furin, trypsin, cathepsins, thermolysin, elastase, phosphatidylinositol 3-phosphate 5-kinase, two-pore segment channel, and epithelium sodium channel C-α subunit). The human cell receptor, ACE2 plays an essential role in the Renin-Angiotensin system (RAS) pathway and COVID-19. Thus, this section also discusses the ACE2 expression and risk of COVID-19 infectivity in various organs and tissues such as the liver, lungs, intestine, heart, and reproductive system in the human body. Absence of ACE2 protein expression in immune cells could be used for limiting the SARS-CoV-2 infection. The third section covers the current available approaches for COVID-19 treatment. Overall, this review focuses on the critical role of human cell receptors involved in coronavirus pathogenesis, which would likely be used in designing target-specific drugs to combat COVID-19." @default.
• W3158210316 created "2021-05-10" @default.
• W3158210316 creator A5036909512 @default.
• W3158210316 creator A5084459620 @default.
• W3158210316 creator A5086841684 @default.
• W3158210316 date "2021-05-05" @default.
• W3158210316 modified "2023-10-01" @default.
• W3158210316 title "Human cell receptors: potential drug targets to combat COVID-19" @default.
• W3158210316 cites W1510264962 @default.
• W3158210316 cites W1544561280 @default.
• W3158210316 cites W1835929051 @default.
• W3158210316 cites W1936357501 @default.
• W3158210316 cites W1964982019 @default.
• W3158210316 cites W1965531501 @default.
• W3158210316 cites W1966238900 @default.
• W3158210316 cites W1970917972 @default.
• W3158210316 cites W1973757205 @default.
• W3158210316 cites W1976400886 @default.
• W3158210316 cites W1976663468 @default.
• W3158210316 cites W1978525739 @default.
• W3158210316 cites W1982920623 @default.
• W3158210316 cites W1983468246 @default.
• W3158210316 cites W1984407952 @default.
• W3158210316 cites W1986942052 @default.
• W3158210316 cites W1990544851 @default.
• W3158210316 cites W1990985479 @default.
• W3158210316 cites W1993577573 @default.
• W3158210316 cites W1995189663 @default.
• W3158210316 cites W1997832988 @default.
• W3158210316 cites W1997896060 @default.
• W3158210316 cites W2001411396 @default.
• W3158210316 cites W2001675896 @default.
• W3158210316 cites W2005951184 @default.
• W3158210316 cites W2006286994 @default.
• W3158210316 cites W2012289331 @default.
• W3158210316 cites W2013090907 @default.
• W3158210316 cites W2022962195 @default.
• W3158210316 cites W2024090372 @default.
• W3158210316 cites W2025170735 @default.
• W3158210316 cites W2025553759 @default.
• W3158210316 cites W2025672718 @default.
• W3158210316 cites W2026445898 @default.
• W3158210316 cites W2028504310 @default.
• W3158210316 cites W2028521865 @default.
• W3158210316 cites W2030005765 @default.
• W3158210316 cites W2037033420 @default.
• W3158210316 cites W2039735909 @default.
• W3158210316 cites W2045052478 @default.
• W3158210316 cites W2046821867 @default.
• W3158210316 cites W2049521850 @default.
• W3158210316 cites W2050308681 @default.
• W3158210316 cites W2054331966 @default.
• W3158210316 cites W2054902365 @default.
• W3158210316 cites W2062041529 @default.
• W3158210316 cites W2062808764 @default.
• W3158210316 cites W2067060165 @default.
• W3158210316 cites W2069411599 @default.
• W3158210316 cites W2070409286 @default.
• W3158210316 cites W2081719521 @default.
• W3158210316 cites W2082514071 @default.
• W3158210316 cites W2085887280 @default.
• W3158210316 cites W2086493164 @default.
• W3158210316 cites W2087499467 @default.
• W3158210316 cites W2088785518 @default.
• W3158210316 cites W2091671824 @default.
• W3158210316 cites W2093852073 @default.
• W3158210316 cites W2097188280 @default.
• W3158210316 cites W2098043374 @default.
• W3158210316 cites W2098086455 @default.
• W3158210316 cites W2098780362 @default.
• W3158210316 cites W2099045066 @default.
• W3158210316 cites W2099549544 @default.
• W3158210316 cites W2100082183 @default.
• W3158210316 cites W2100409734 @default.
• W3158210316 cites W2101506295 @default.
• W3158210316 cites W2101796829 @default.
• W3158210316 cites W2106842109 @default.
• W3158210316 cites W2107395201 @default.
• W3158210316 cites W2118638261 @default.
• W3158210316 cites W2119111857 @default.
• W3158210316 cites W2119630077 @default.
• W3158210316 cites W2121056625 @default.
• W3158210316 cites W2124198028 @default.
• W3158210316 cites W2126060958 @default.
• W3158210316 cites W2129577287 @default.
• W3158210316 cites W2130892150 @default.
• W3158210316 cites W2133217116 @default.
• W3158210316 cites W2134872401 @default.
• W3158210316 cites W2138324310 @default.
• W3158210316 cites W2140823754 @default.
• W3158210316 cites W2141108790 @default.
• W3158210316 cites W2143546506 @default.
• W3158210316 cites W2144724313 @default.
• W3158210316 cites W2146374988 @default.
• W3158210316 cites W2146476111 @default.
• W3158210316 cites W2147515973 @default.
• W3158210316 cites W2149146712 @default.
• W3158210316 cites W2158922816 @default.

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