Matches in SemOpenAlex for { <https://semopenalex.org/work/W3158241969> ?p ?o ?g. }
- W3158241969 abstract "Abstract Infection of human cells by pathogens, including SARS-CoV-2, typically proceeds by cell surface binding to a crucial receptor. In the case of SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2) has been identified as a necessary receptor, but not all ACE2-expressing cells are equally infected, suggesting that other extracellular factors are involved in host cell invasion by SARS-CoV-2. Vimentin is an intermediate filament protein that is increasingly recognized as being present on the extracellular surface of a subset of cell types, where it can bind to and facilitate pathogens’ cellular uptake. Here, we present evidence that extracellular vimentin might act as a critical component of the SARS-CoV-2 spike protein-ACE2 complex in mediating SARS-CoV-2 cell entry. We demonstrate direct binding between vimentin and SARS-CoV-2 pseudovirus coated with the SARS-CoV-2 spike protein and show that antibodies against vimentin block in vitro SARS-CoV-2 pseudovirus infection of ACE2-expressing cells. Our results suggest new therapeutic strategies for preventing and slowing SARS-CoV-2 infection, focusing on targeting cell host surface vimentin." @default.
- W3158241969 created "2021-05-10" @default.
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- W3158241969 date "2021-01-08" @default.
- W3158241969 modified "2023-10-14" @default.
- W3158241969 title "Extracellular vimentin as a target against SARS-CoV-2 host cell invasion" @default.
- W3158241969 cites W1485384468 @default.
- W3158241969 cites W1617187037 @default.
- W3158241969 cites W1917401432 @default.
- W3158241969 cites W1964081206 @default.
- W3158241969 cites W1966820455 @default.
- W3158241969 cites W1979412088 @default.
- W3158241969 cites W1990985479 @default.
- W3158241969 cites W1992920740 @default.
- W3158241969 cites W1995097523 @default.
- W3158241969 cites W1998275580 @default.
- W3158241969 cites W2025680762 @default.
- W3158241969 cites W2026158123 @default.
- W3158241969 cites W2028504310 @default.
- W3158241969 cites W2041408897 @default.
- W3158241969 cites W2047809394 @default.
- W3158241969 cites W2054331966 @default.
- W3158241969 cites W2061457168 @default.
- W3158241969 cites W2062288622 @default.
- W3158241969 cites W2066443345 @default.
- W3158241969 cites W2086493164 @default.
- W3158241969 cites W2093977796 @default.
- W3158241969 cites W2094448241 @default.
- W3158241969 cites W2105721198 @default.
- W3158241969 cites W2121494157 @default.
- W3158241969 cites W2127910803 @default.
- W3158241969 cites W2141522272 @default.
- W3158241969 cites W2141959911 @default.
- W3158241969 cites W2142667010 @default.
- W3158241969 cites W2143300823 @default.
- W3158241969 cites W2147577544 @default.
- W3158241969 cites W2167523852 @default.
- W3158241969 cites W2168982611 @default.
- W3158241969 cites W2255914879 @default.
- W3158241969 cites W2372119441 @default.
- W3158241969 cites W2410615307 @default.
- W3158241969 cites W2466632485 @default.
- W3158241969 cites W2512867860 @default.
- W3158241969 cites W2521799152 @default.
- W3158241969 cites W2548027654 @default.
- W3158241969 cites W2558649667 @default.
- W3158241969 cites W2588186710 @default.
- W3158241969 cites W2592683935 @default.
- W3158241969 cites W2610792799 @default.
- W3158241969 cites W2620431387 @default.
- W3158241969 cites W2766204873 @default.
- W3158241969 cites W2783962842 @default.
- W3158241969 cites W2793196316 @default.
- W3158241969 cites W2801723256 @default.
- W3158241969 cites W2803084464 @default.
- W3158241969 cites W2807134398 @default.
- W3158241969 cites W2822464395 @default.
- W3158241969 cites W2884452841 @default.
- W3158241969 cites W2889835308 @default.
- W3158241969 cites W2894071780 @default.
- W3158241969 cites W2948037350 @default.
- W3158241969 cites W2948622157 @default.
- W3158241969 cites W2980366253 @default.
- W3158241969 cites W3001897055 @default.
- W3158241969 cites W3006746866 @default.
- W3158241969 cites W3007643904 @default.
- W3158241969 cites W3007704142 @default.
- W3158241969 cites W3009912996 @default.
- W3158241969 cites W3011398105 @default.
- W3158241969 cites W3011483298 @default.
- W3158241969 cites W3011490235 @default.
- W3158241969 cites W3013420240 @default.
- W3158241969 cites W3014338896 @default.
- W3158241969 cites W3014912119 @default.
- W3158241969 cites W3014992166 @default.
- W3158241969 cites W3017850114 @default.
- W3158241969 cites W3022529555 @default.
- W3158241969 cites W3026328714 @default.
- W3158241969 cites W3030748957 @default.
- W3158241969 cites W3033074647 @default.
- W3158241969 cites W3033259606 @default.
- W3158241969 cites W3038107455 @default.
- W3158241969 cites W3043649968 @default.
- W3158241969 cites W3045474919 @default.
- W3158241969 cites W3047113304 @default.