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- W3158242012 startingPage "71" @default.
- W3158242012 abstract "Genetically encoded biological clocks are found broadly throughout life on Earth, where they generate circadian (about a day) rhythms that synchronize physiology and behavior with the daily light/dark cycle. Although the genetic networks that give rise to circadian timing are now fairly well established, our understanding of how the proteins that constitute the molecular ‘cogs’ of this biological clock regulate the intrinsic timing, or period, of circadian rhythms has lagged behind. New studies probing the biochemical and structural basis of clock protein function are beginning to reveal how assemblies of dedicated clock proteins form and evolve through post-translational regulation to generate circadian rhythms. This review will highlight some recent advances providing important insight into the molecular mechanisms of period control in mammalian clocks with an emphasis on structural analyses related to CK1-dependent control of PER stability." @default.
- W3158242012 created "2021-05-10" @default.
- W3158242012 creator A5021864264 @default.
- W3158242012 creator A5045450888 @default.
- W3158242012 creator A5061209605 @default.
- W3158242012 creator A5063442972 @default.
- W3158242012 date "2022-06-01" @default.
- W3158242012 modified "2023-09-27" @default.
- W3158242012 title "Biochemical mechanisms of period control within the mammalian circadian clock" @default.
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