FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3158291444> ?p ?o ?g. }

• W3158291444 abstract "The entorhinal cortex (EC) is the spatial processing center of the brain and structurally is an interface between the three layered paleocortex and six layered neocortex, known as the periarchicortex. Limited studies indicate peculiarities in the formation of the EC such as early emergence of cells in layers (L) II and late deposition of LIII, as well as divergence in the timing of maturation of cell types in the superficial layers. In this study, we examine developmental events in the entorhinal cortex using an understudied model in neuroanatomy and development, the pig and supplement the research with BrdU labeling in the developing mouse EC. We determine the pig serves as an excellent anatomical model for studying human neurogenesis, given its long gestational length, presence of a moderate sized outer subventricular zone and early cessation of neurogenesis during gestation. Immunohistochemistry identified prominent clusters of OLIG2 + oligoprogenitor-like cells in the superficial layers of the lateral EC (LEC) that are sparser in the medial EC (MEC). These are first detected in the subplate during the early second trimester. MRI analyses reveal an acceleration of EC growth at the end of the second trimester. BrdU labeling of the developing MEC, shows the deeper layers form first and prior to the superficial layers, but the LV/VI emerges in parallel and the LII/III emerges later, but also in parallel. We coin this lamination pattern parallel lamination. The early born Reln + stellate cells in the superficial layers express the classic LV marker, Bcl11b (Ctip2) and arise from a common progenitor that forms the late deep layer LV neurons. In summary, we characterize the developing EC in a novel animal model and outline in detail the formation of the EC. We further provide insight into how the periarchicortex forms in the brain, which differs remarkably to the inside-out lamination of the neocortex." @default.
• W3158291444 created "2021-05-10" @default.
• W3158291444 creator A5004614832 @default.
• W3158291444 creator A5008188163 @default.
• W3158291444 creator A5014115346 @default.
• W3158291444 creator A5044386095 @default.
• W3158291444 creator A5048018705 @default.
• W3158291444 creator A5055341260 @default.
• W3158291444 creator A5057031090 @default.
• W3158291444 creator A5059561479 @default.
• W3158291444 creator A5070290386 @default.
• W3158291444 creator A5080094791 @default.
• W3158291444 creator A5080136004 @default.
• W3158291444 creator A5082500335 @default.
• W3158291444 creator A5090129110 @default.
• W3158291444 date "2021-05-05" @default.
• W3158291444 modified "2023-10-15" @default.
• W3158291444 title "Development of the Entorhinal Cortex Occurs via Parallel Lamination During Neurogenesis" @default.
• W3158291444 cites W1523904580 @default.
• W3158291444 cites W1530869325 @default.
• W3158291444 cites W1594381616 @default.
• W3158291444 cites W1604336286 @default.
• W3158291444 cites W1969298980 @default.
• W3158291444 cites W1979890518 @default.
• W3158291444 cites W1980796284 @default.
• W3158291444 cites W1981039366 @default.
• W3158291444 cites W1981697483 @default.
• W3158291444 cites W1985705162 @default.
• W3158291444 cites W1987775243 @default.
• W3158291444 cites W1997888430 @default.
• W3158291444 cites W1999362269 @default.
• W3158291444 cites W1999856091 @default.
• W3158291444 cites W2000345419 @default.
• W3158291444 cites W2002772036 @default.
• W3158291444 cites W2006931629 @default.
• W3158291444 cites W2011358132 @default.
• W3158291444 cites W2011978143 @default.
• W3158291444 cites W2014277329 @default.
• W3158291444 cites W2027029586 @default.
• W3158291444 cites W2030135612 @default.
• W3158291444 cites W2030680267 @default.
• W3158291444 cites W2030691940 @default.
• W3158291444 cites W2034786388 @default.
• W3158291444 cites W2038472858 @default.
• W3158291444 cites W2040107985 @default.
• W3158291444 cites W2047002192 @default.
• W3158291444 cites W2047092649 @default.
• W3158291444 cites W2047622680 @default.
• W3158291444 cites W2052842784 @default.
• W3158291444 cites W2062795539 @default.
• W3158291444 cites W2069287095 @default.
• W3158291444 cites W2069899696 @default.
• W3158291444 cites W2070051129 @default.
• W3158291444 cites W2070493436 @default.
• W3158291444 cites W2071549768 @default.
• W3158291444 cites W2072569914 @default.
• W3158291444 cites W2074480828 @default.
• W3158291444 cites W2078397140 @default.
• W3158291444 cites W2083760008 @default.
• W3158291444 cites W2091543295 @default.
• W3158291444 cites W2117719082 @default.
• W3158291444 cites W2127890285 @default.
• W3158291444 cites W2138921976 @default.
• W3158291444 cites W2139219423 @default.
• W3158291444 cites W2139452105 @default.
• W3158291444 cites W2141689891 @default.
• W3158291444 cites W2142565835 @default.
• W3158291444 cites W2143981060 @default.
• W3158291444 cites W2147467366 @default.
• W3158291444 cites W2158154597 @default.
• W3158291444 cites W2191490370 @default.
• W3158291444 cites W2194591868 @default.
• W3158291444 cites W2212004698 @default.
• W3158291444 cites W2307886346 @default.
• W3158291444 cites W2322843381 @default.
• W3158291444 cites W2395403489 @default.
• W3158291444 cites W2535699770 @default.
• W3158291444 cites W2537685252 @default.
• W3158291444 cites W2547009870 @default.
• W3158291444 cites W2583713893 @default.
• W3158291444 cites W2728927411 @default.
• W3158291444 cites W2738397984 @default.
• W3158291444 cites W2761829250 @default.
• W3158291444 cites W2767320216 @default.
• W3158291444 cites W2794222125 @default.
• W3158291444 cites W2889607052 @default.
• W3158291444 cites W2907254967 @default.
• W3158291444 cites W2908670724 @default.
• W3158291444 cites W2944137180 @default.
• W3158291444 cites W2949976526 @default.
• W3158291444 cites W2971850022 @default.
• W3158291444 cites W2983726174 @default.
• W3158291444 cites W3037023113 @default.
• W3158291444 cites W3080237557 @default.
• W3158291444 cites W4250313945 @default.
• W3158291444 cites W4376849741 @default.
• W3158291444 doi "https://doi.org/10.3389/fnana.2021.663667" @default.
• W3158291444 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8139189" @default.
• W3158291444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34025365" @default.
• W3158291444 hasPublicationYear "2021" @default.

• next