FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3158430666> ?p ?o ?g. }

• W3158430666 endingPage "561" @default.
• W3158430666 startingPage "554" @default.
• W3158430666 abstract "Recommendations regarding vancomycin dosing in critically ill patients on continuous venovenous hemofiltration (CVVH) are limited. The purpose of this study was to evaluate current dosing practices of pharmacists for patients treated with CVVH, develop guidelines for optimal dosing and monitoring of vancomycin to improve target trough attainment, and reduce pharmacist workload.A retrospective cohort study. was performed of critically ill adult patients from January 2015 to December 2018. Patients were included if they received vancomycin during CVVH for at least 48 h. Patients with significant residual kidney function, defined as daily urine output >400 ml or significant fluctuations (≥1000 ml/h in a 24-h period) in their hemofiltration rates, were excluded. Interruptions in CVVH up to 6 h/day were permitted. Dosing strategies with two dosing categories were defined: (1) dosing based on random serum levels (dosing by level, DBL) or (2) scheduled vancomycin dosing (SD).Academic medical center in Detroit, Michigan.Critically ill adult patients.During the study period, 942 patients were evaluated and 200 met inclusion criteria, for a total of 586 serum vancomycin levels. There were 141 patients with 443 random vancomycin serum levels in the DBL group and 59 patients with143 vancomycin trough levels in the SD group. Mean vancomycin trough levels were similar between groups (17.1 ± 6 vs. 16.5 ± 4 mcg/ml) for the DBL and SD groups, respectively. For the primary end point of overall target trough achievement of 15-20 mcg/ml, significantly more trough levels in the SD group were in the 15-20 mcg/ml range compared with the DBL group, 50% vs. 38%; p < 0.001, respectively. When target trough range was extended to 10-20 mcg/ml, success rates were similar between groups (74% DBL vs. 82% SD, p = 0.021). The number of interventions required by the pharmacist, including notes per day and orders per day, were reduced by approximately 50% when the SD strategy was utilized. Scheduled vancomycin dosing regimens of 15-22 mg/kg every 12-24 h were required to yield trough levels in the 15-20 mcg/ml range.Target vancomycin trough achievement of 15-20 mcg/ml occurred more frequently when vancomycin was scheduled at a dose of 15-22 mg/kg every 12-24 h based on ultrafiltration rate and may alleviate the time and cost associated with frequent vancomycin serum monitoring." @default.
• W3158430666 created "2021-05-10" @default.
• W3158430666 creator A5014466932 @default.
• W3158430666 creator A5033518279 @default.
• W3158430666 creator A5043091412 @default.
• W3158430666 creator A5050655947 @default.
• W3158430666 creator A5058963493 @default.
• W3158430666 date "2021-06-18" @default.
• W3158430666 modified "2023-09-25" @default.
• W3158430666 title "Evaluation of dosing strategies and trough concentrations of vancomycin in patients undergoing continuous venovenous hemofiltration" @default.
• W3158430666 cites W1964233205 @default.
• W3158430666 cites W1968978209 @default.
• W3158430666 cites W1970058753 @default.
• W3158430666 cites W1979060371 @default.
• W3158430666 cites W2010066166 @default.
• W3158430666 cites W2016626098 @default.
• W3158430666 cites W2023309638 @default.
• W3158430666 cites W2045264488 @default.
• W3158430666 cites W2045314484 @default.
• W3158430666 cites W2094256798 @default.
• W3158430666 cites W2101713840 @default.
• W3158430666 cites W2130937463 @default.
• W3158430666 cites W2133613588 @default.
• W3158430666 cites W2140147718 @default.
• W3158430666 cites W2143376166 @default.
• W3158430666 cites W2161960287 @default.
• W3158430666 cites W2407363578 @default.
• W3158430666 cites W2408998972 @default.
• W3158430666 cites W2763325703 @default.
• W3158430666 cites W2987587756 @default.
• W3158430666 cites W3012260518 @default.
• W3158430666 cites W3032253244 @default.
• W3158430666 cites W3045454797 @default.
• W3158430666 doi "https://doi.org/10.1002/phar.2535" @default.
• W3158430666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33963536" @default.
• W3158430666 hasPublicationYear "2021" @default.
• W3158430666 type Work @default.
• W3158430666 sameAs 3158430666 @default.
• W3158430666 citedByCount "6" @default.
• W3158430666 countsByYear W31584306662021 @default.
• W3158430666 countsByYear W31584306662022 @default.
• W3158430666 countsByYear W31584306662023 @default.
• W3158430666 crossrefType "journal-article" @default.
• W3158430666 hasAuthorship W3158430666A5014466932 @default.
• W3158430666 hasAuthorship W3158430666A5033518279 @default.
• W3158430666 hasAuthorship W3158430666A5043091412 @default.
• W3158430666 hasAuthorship W3158430666A5050655947 @default.
• W3158430666 hasAuthorship W3158430666A5058963493 @default.
• W3158430666 hasConcept C126322002 @default.
• W3158430666 hasConcept C141071460 @default.
• W3158430666 hasConcept C167135981 @default.
• W3158430666 hasConcept C2777288759 @default.
• W3158430666 hasConcept C2778980435 @default.
• W3158430666 hasConcept C2779489039 @default.
• W3158430666 hasConcept C2909675724 @default.
• W3158430666 hasConcept C2910800852 @default.
• W3158430666 hasConcept C2911091166 @default.
• W3158430666 hasConcept C31785415 @default.
• W3158430666 hasConcept C42219234 @default.
• W3158430666 hasConcept C523546767 @default.
• W3158430666 hasConcept C54355233 @default.
• W3158430666 hasConcept C71924100 @default.
• W3158430666 hasConcept C86803240 @default.
• W3158430666 hasConceptScore W3158430666C126322002 @default.
• W3158430666 hasConceptScore W3158430666C141071460 @default.
• W3158430666 hasConceptScore W3158430666C167135981 @default.
• W3158430666 hasConceptScore W3158430666C2777288759 @default.
• W3158430666 hasConceptScore W3158430666C2778980435 @default.
• W3158430666 hasConceptScore W3158430666C2779489039 @default.
• W3158430666 hasConceptScore W3158430666C2909675724 @default.
• W3158430666 hasConceptScore W3158430666C2910800852 @default.
• W3158430666 hasConceptScore W3158430666C2911091166 @default.
• W3158430666 hasConceptScore W3158430666C31785415 @default.
• W3158430666 hasConceptScore W3158430666C42219234 @default.
• W3158430666 hasConceptScore W3158430666C523546767 @default.
• W3158430666 hasConceptScore W3158430666C54355233 @default.
• W3158430666 hasConceptScore W3158430666C71924100 @default.
• W3158430666 hasConceptScore W3158430666C86803240 @default.
• W3158430666 hasIssue "7" @default.
• W3158430666 hasLocation W31584306661 @default.
• W3158430666 hasLocation W31584306662 @default.
• W3158430666 hasOpenAccess W3158430666 @default.
• W3158430666 hasPrimaryLocation W31584306661 @default.
• W3158430666 hasRelatedWork W1831522254 @default.
• W3158430666 hasRelatedWork W1989051318 @default.
• W3158430666 hasRelatedWork W2154361835 @default.
• W3158430666 hasRelatedWork W2160515228 @default.
• W3158430666 hasRelatedWork W2170749810 @default.
• W3158430666 hasRelatedWork W2912845088 @default.
• W3158430666 hasRelatedWork W3032383577 @default.
• W3158430666 hasRelatedWork W4225930705 @default.
• W3158430666 hasRelatedWork W4313729222 @default.
• W3158430666 hasRelatedWork W2557200397 @default.
• W3158430666 hasVolume "41" @default.
• W3158430666 isParatext "false" @default.
• W3158430666 isRetracted "false" @default.
• W3158430666 magId "3158430666" @default.
• W3158430666 workType "article" @default.