FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3158473492> ?p ?o ?g. }

• W3158473492 endingPage "120862" @default.
• W3158473492 startingPage "120862" @default.
• W3158473492 abstract "Smoke inhalation injury is associated with significant mortality and current therapies remain supportive. The purpose of our study was to identify proteins upregulated in the lung after smoke inhalation injury and develop peptide amphiphile nanofibers that target these proteins. We hypothesize that nanofibers targeted to angiotensin-converting enzyme or receptor for advanced glycation end products will localize to smoke-injured lungs.Five targeting sequences were incorporated into peptide amphiphile monomers methodically to optimize nanofiber formation. Nanofiber formation was assessed by conventional transmission electron microscopy. Rats received 8 min of wood smoke. Levels of angiotensin-converting enzyme and receptor for advanced glycation end products were evaluated by immunofluorescence. Rats received the targeted nanofiber 23 h after injury via tail vein injection. Nanofiber localization was determined by fluorescence quantification.Peptide amphiphile purity (>95%) and nanofiber formation were confirmed. Target proteins were increased in smoke inhalation versus sham (p < 0.001). After smoke inhalation and injection of targeted nanofibers, we found a 10-fold increase in angiotensin-converting enzyme-targeted nanofiber localization to lung (p < 0.001) versus sham with minimal localization of non-targeted nanofiber (p < 0.001).We synthesized, characterized, and evaluated systemically delivered targeted nanofibers that localized to the site of smoke inhalation injury in vivo. Angiotensin-converting enzyme-targeted nanofibers serve as the foundation for developing a novel nanotherapeutic that treats smoke inhalation lung injury." @default.
• W3158473492 created "2021-05-10" @default.
• W3158473492 creator A5006604356 @default.
• W3158473492 creator A5021095261 @default.
• W3158473492 creator A5033499525 @default.
• W3158473492 creator A5035857077 @default.
• W3158473492 creator A5036823679 @default.
• W3158473492 creator A5045868708 @default.
• W3158473492 creator A5048905687 @default.
• W3158473492 creator A5049647470 @default.
• W3158473492 creator A5051357380 @default.
• W3158473492 creator A5061660001 @default.
• W3158473492 creator A5069815172 @default.
• W3158473492 creator A5076287889 @default.
• W3158473492 creator A5079222349 @default.
• W3158473492 date "2021-07-01" @default.
• W3158473492 modified "2023-10-16" @default.
• W3158473492 title "Development of novel nanofibers targeted to smoke-injured lungs" @default.
• W3158473492 cites W1488595916 @default.
• W3158473492 cites W1607053696 @default.
• W3158473492 cites W1921824630 @default.
• W3158473492 cites W1964982019 @default.
• W3158473492 cites W1967555827 @default.
• W3158473492 cites W1972609612 @default.
• W3158473492 cites W1973134807 @default.
• W3158473492 cites W1975088956 @default.
• W3158473492 cites W1989275496 @default.
• W3158473492 cites W1990556507 @default.
• W3158473492 cites W2021474832 @default.
• W3158473492 cites W2028117310 @default.
• W3158473492 cites W2031503849 @default.
• W3158473492 cites W2043688731 @default.
• W3158473492 cites W2052340241 @default.
• W3158473492 cites W2081833688 @default.
• W3158473492 cites W2171671715 @default.
• W3158473492 cites W2204240261 @default.
• W3158473492 cites W2302132407 @default.
• W3158473492 cites W2313221601 @default.
• W3158473492 cites W2328665600 @default.
• W3158473492 cites W2336820302 @default.
• W3158473492 cites W2397060358 @default.
• W3158473492 cites W2420826700 @default.
• W3158473492 cites W2509253412 @default.
• W3158473492 cites W2526397698 @default.
• W3158473492 cites W2625716828 @default.
• W3158473492 cites W2739685450 @default.
• W3158473492 cites W2749367413 @default.
• W3158473492 cites W2777517099 @default.
• W3158473492 cites W2784579142 @default.
• W3158473492 cites W2791797623 @default.
• W3158473492 cites W2896713706 @default.
• W3158473492 cites W2909644220 @default.
• W3158473492 cites W2944593874 @default.
• W3158473492 cites W2957539143 @default.
• W3158473492 cites W2981946651 @default.
• W3158473492 cites W3013396964 @default.
• W3158473492 cites W3044505798 @default.
• W3158473492 cites W4239858085 @default.
• W3158473492 cites W4247174240 @default.
• W3158473492 doi "https://doi.org/10.1016/j.biomaterials.2021.120862" @default.
• W3158473492 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8184637" @default.
• W3158473492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33975274" @default.
• W3158473492 hasPublicationYear "2021" @default.
• W3158473492 type Work @default.
• W3158473492 sameAs 3158473492 @default.
• W3158473492 citedByCount "3" @default.
• W3158473492 countsByYear W31584734922022 @default.
• W3158473492 countsByYear W31584734922023 @default.
• W3158473492 crossrefType "journal-article" @default.
• W3158473492 hasAuthorship W3158473492A5006604356 @default.
• W3158473492 hasAuthorship W3158473492A5021095261 @default.
• W3158473492 hasAuthorship W3158473492A5033499525 @default.
• W3158473492 hasAuthorship W3158473492A5035857077 @default.
• W3158473492 hasAuthorship W3158473492A5036823679 @default.
• W3158473492 hasAuthorship W3158473492A5045868708 @default.
• W3158473492 hasAuthorship W3158473492A5048905687 @default.
• W3158473492 hasAuthorship W3158473492A5049647470 @default.
• W3158473492 hasAuthorship W3158473492A5051357380 @default.
• W3158473492 hasAuthorship W3158473492A5061660001 @default.
• W3158473492 hasAuthorship W3158473492A5069815172 @default.
• W3158473492 hasAuthorship W3158473492A5076287889 @default.
• W3158473492 hasAuthorship W3158473492A5079222349 @default.
• W3158473492 hasBestOaLocation W31584734921 @default.
• W3158473492 hasConcept C126322002 @default.
• W3158473492 hasConcept C147990577 @default.
• W3158473492 hasConcept C170493617 @default.
• W3158473492 hasConcept C171250308 @default.
• W3158473492 hasConcept C192562407 @default.
• W3158473492 hasConcept C2776954882 @default.
• W3158473492 hasConcept C2777390754 @default.
• W3158473492 hasConcept C42219234 @default.
• W3158473492 hasConcept C71924100 @default.
• W3158473492 hasConcept C91129048 @default.
• W3158473492 hasConceptScore W3158473492C126322002 @default.
• W3158473492 hasConceptScore W3158473492C147990577 @default.
• W3158473492 hasConceptScore W3158473492C170493617 @default.
• W3158473492 hasConceptScore W3158473492C171250308 @default.
• W3158473492 hasConceptScore W3158473492C192562407 @default.

• next