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- W3158477759 abstract "Abstract Multiple myeloma (MM) is characterized by the uncontrolled proliferation of plasma cells. Despite recent treatment advances, it is still incurable as disease progression is not fully understood. To investigate MM and its immune environment, we apply single cell RNA and linked-read whole genome sequencing to profile 29 longitudinal samples at different disease stages from 14 patients. Here, we collect 17,267 plasma cells and 57,719 immune cells, discovering patient-specific plasma cell profiles and immune cell expression changes. Patients with the same genetic alterations tend to have both plasma cells and immune cells clustered together. By integrating bulk genomics and single cell mapping, we track plasma cell subpopulations across disease stages and find three patterns: stability (from precancer to diagnosis), and gain or loss (from diagnosis to relapse). In multiple patients, we detect “B cell-featured” plasma cell subpopulations that cluster closely with B cells, implicating their cell of origin. We validate AP-1 complex differential expression (JUN and FOS) in plasma cell subpopulations using CyTOF-based protein assays, and integrated analysis of single-cell RNA and CyTOF data reveals AP-1 downstream targets (IL6 and IL1B) potentially leading to inflammation regulation. Our work represents a longitudinal investigation for tumor and microenvironment during MM progression and paves the way for expanding treatment options." @default.
- W3158477759 created "2021-05-10" @default.
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- W3158477759 date "2021-05-07" @default.
- W3158477759 modified "2023-10-18" @default.
- W3158477759 title "Co-evolution of tumor and immune cells during progression of multiple myeloma" @default.
- W3158477759 cites W1608640012 @default.
- W3158477759 cites W1625061727 @default.
- W3158477759 cites W1902692042 @default.
- W3158477759 cites W1970090817 @default.
- W3158477759 cites W1979115864 @default.
- W3158477759 cites W1982474866 @default.
- W3158477759 cites W1983357242 @default.
- W3158477759 cites W1985864219 @default.
- W3158477759 cites W1992826811 @default.
- W3158477759 cites W2024626836 @default.
- W3158477759 cites W2030017878 @default.
- W3158477759 cites W2032518018 @default.
- W3158477759 cites W2037346352 @default.
- W3158477759 cites W2038477042 @default.
- W3158477759 cites W2053633180 @default.
- W3158477759 cites W2055662838 @default.
- W3158477759 cites W2060187655 @default.
- W3158477759 cites W2067697860 @default.
- W3158477759 cites W2082726173 @default.
- W3158477759 cites W2086918627 @default.
- W3158477759 cites W2087843841 @default.
- W3158477759 cites W2089902119 @default.
- W3158477759 cites W2090114802 @default.
- W3158477759 cites W2093014337 @default.
- W3158477759 cites W2093123744 @default.
- W3158477759 cites W2097455931 @default.
- W3158477759 cites W2099070260 @default.
- W3158477759 cites W2101035019 @default.
- W3158477759 cites W2104195581 @default.
- W3158477759 cites W2104549677 @default.
- W3158477759 cites W2111163979 @default.
- W3158477759 cites W2111874706 @default.
- W3158477759 cites W2117034500 @default.
- W3158477759 cites W2117246760 @default.
- W3158477759 cites W2119180969 @default.
- W3158477759 cites W2120474651 @default.
- W3158477759 cites W2129248963 @default.
- W3158477759 cites W2135047926 @default.
- W3158477759 cites W2138597400 @default.
- W3158477759 cites W2138601221 @default.
- W3158477759 cites W2141149919 @default.
- W3158477759 cites W2146290346 @default.
- W3158477759 cites W2152568820 @default.
- W3158477759 cites W2154397429 @default.
- W3158477759 cites W2154819492 @default.
- W3158477759 cites W2155165473 @default.
- W3158477759 cites W2155943701 @default.
- W3158477759 cites W2164269013 @default.
- W3158477759 cites W2167202194 @default.
- W3158477759 cites W2169846247 @default.
- W3158477759 cites W2225520394 @default.
- W3158477759 cites W2235737683 @default.
- W3158477759 cites W2259938310 @default.
- W3158477759 cites W2264578395 @default.
- W3158477759 cites W2323326409 @default.
- W3158477759 cites W2337126618 @default.
- W3158477759 cites W2337209831 @default.
- W3158477759 cites W2419528132 @default.
- W3158477759 cites W2506420452 @default.
- W3158477759 cites W2511571730 @default.
- W3158477759 cites W2518882166 @default.
- W3158477759 cites W2551783467 @default.
- W3158477759 cites W2567188480 @default.
- W3158477759 cites W2606564035 @default.
- W3158477759 cites W2747877289 @default.
- W3158477759 cites W2749746182 @default.