FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3158536705> ?p ?o ?g. }

• W3158536705 abstract "MicroRNAs (miRNAs/miRs) are key regulators of renal interstitial fibrosis (RIF). The present study was designed to identify miRNAs associated with the development of RIF, and to explore the ability of these identified miRNAs to modulate the renal tubular epithelial‑to‑mesenchymal transition (EMT) process. To this end, miRNAs that were differentially expressed between normal and fibrotic kidneys in a rat model of mercury chloride (HgCl₂)‑induced RIF were detected via an array‑based approach. Bioinformatics analyses revealed that miR‑101 was the miRNA that was most significantly downregulated in the fibrotic renal tissue samples, and this was confirmed by RT‑qPCR, which also demonstrated that this miRNA was downregulated in transforming growth factor (TGF)‑β1‑treated human proximal tubular epithelial (HK‑2) cells. When miR‑101 was overexpressed, this was sufficient to reverse TGF‑β1‑induced EMT in HK‑2 cells, leading to the upregulation of the epithelial marker, E‑cadherin, and the downregulation of the mesenchymal marker, α‑smooth muscle actin. By contrast, the downregulation of miR‑101 using an inhibitor exerted the opposite effect. The overexpression of miR‑101 also suppressed the expression of the miR‑101 target gene, TGF‑β1 type I receptor (TβR‑I), and thereby impaired TGF‑β1/Smad3 signaling, while the opposite was observed upon miR‑101 inhibition. To further confirm the ability of miR‑101 to modulate EMT, the HK‑2 cells were treated with the TβR‑I inhibitor, SB‑431542, which significantly suppressed TGF‑β1‑induced EMT in these cells. Notably, miR‑101 inhibition exerted a less pronounced effect upon EMT‑related phenotypes in these TβR‑I inhibitor‑treated HK‑2 cells, supporting a model wherein miR‑101 inhibits TGF‑β1‑induced EMT by suppressing TβR‑I expression. On the whole, the present study demonstrates that miR‑101 is capable of inhibiting TGF‑β1‑induced tubular EMT by targeting TβR‑I, suggesting that it may be an important regulator of RIF." @default.
• W3158536705 created "2021-05-10" @default.
• W3158536705 creator A5017467059 @default.
• W3158536705 creator A5031751057 @default.
• W3158536705 creator A5071737183 @default.
• W3158536705 creator A5074880411 @default.
• W3158536705 creator A5077153113 @default.
• W3158536705 date "2021-04-29" @default.
• W3158536705 modified "2023-10-16" @default.
• W3158536705 title "MicroRNA‑101 inhibits renal tubular epithelial‑to‑mesenchymal transition by targeting TGF‑β1 type I receptor" @default.
• W3158536705 cites W1204326888 @default.
• W3158536705 cites W1760215417 @default.
• W3158536705 cites W1965151940 @default.
• W3158536705 cites W1982406043 @default.
• W3158536705 cites W19843932 @default.
• W3158536705 cites W1992728833 @default.
• W3158536705 cites W1999976118 @default.
• W3158536705 cites W2003599465 @default.
• W3158536705 cites W2004235434 @default.
• W3158536705 cites W2023560350 @default.
• W3158536705 cites W2033457930 @default.
• W3158536705 cites W2043332255 @default.
• W3158536705 cites W2046507484 @default.
• W3158536705 cites W2054282870 @default.
• W3158536705 cites W2081098333 @default.
• W3158536705 cites W2081504566 @default.
• W3158536705 cites W2097888088 @default.
• W3158536705 cites W2101766543 @default.
• W3158536705 cites W2107277218 @default.
• W3158536705 cites W2108517613 @default.
• W3158536705 cites W2112785261 @default.
• W3158536705 cites W2115141581 @default.
• W3158536705 cites W2117391818 @default.
• W3158536705 cites W2119885610 @default.
• W3158536705 cites W2150572884 @default.
• W3158536705 cites W2153195747 @default.
• W3158536705 cites W2156415904 @default.
• W3158536705 cites W2163106706 @default.
• W3158536705 cites W2168918540 @default.
• W3158536705 cites W2179401868 @default.
• W3158536705 cites W2301237734 @default.
• W3158536705 cites W2473580248 @default.
• W3158536705 cites W2588446266 @default.
• W3158536705 cites W2736691594 @default.
• W3158536705 cites W2747456001 @default.
• W3158536705 cites W2903915221 @default.
• W3158536705 cites W2912704105 @default.
• W3158536705 cites W2912777361 @default.
• W3158536705 cites W2921372367 @default.
• W3158536705 cites W2973222576 @default.
• W3158536705 cites W2989577220 @default.
• W3158536705 cites W3040787009 @default.
• W3158536705 doi "https://doi.org/10.3892/ijmm.2021.4952" @default.
• W3158536705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8099196" @default.
• W3158536705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33955520" @default.
• W3158536705 hasPublicationYear "2021" @default.
• W3158536705 type Work @default.
• W3158536705 sameAs 3158536705 @default.
• W3158536705 citedByCount "7" @default.
• W3158536705 countsByYear W31585367052021 @default.
• W3158536705 countsByYear W31585367052022 @default.
• W3158536705 countsByYear W31585367052023 @default.
• W3158536705 crossrefType "journal-article" @default.
• W3158536705 hasAuthorship W3158536705A5017467059 @default.
• W3158536705 hasAuthorship W3158536705A5031751057 @default.
• W3158536705 hasAuthorship W3158536705A5071737183 @default.
• W3158536705 hasAuthorship W3158536705A5074880411 @default.
• W3158536705 hasAuthorship W3158536705A5077153113 @default.
• W3158536705 hasBestOaLocation W31585367051 @default.
• W3158536705 hasConcept C104317684 @default.
• W3158536705 hasConcept C118131993 @default.
• W3158536705 hasConcept C127561419 @default.
• W3158536705 hasConcept C145059251 @default.
• W3158536705 hasConcept C1491633281 @default.
• W3158536705 hasConcept C153911025 @default.
• W3158536705 hasConcept C185592680 @default.
• W3158536705 hasConcept C198826908 @default.
• W3158536705 hasConcept C2781018059 @default.
• W3158536705 hasConcept C29537977 @default.
• W3158536705 hasConcept C502942594 @default.
• W3158536705 hasConcept C55493867 @default.
• W3158536705 hasConcept C76419328 @default.
• W3158536705 hasConcept C86803240 @default.
• W3158536705 hasConcept C95444343 @default.
• W3158536705 hasConceptScore W3158536705C104317684 @default.
• W3158536705 hasConceptScore W3158536705C118131993 @default.
• W3158536705 hasConceptScore W3158536705C127561419 @default.
• W3158536705 hasConceptScore W3158536705C145059251 @default.
• W3158536705 hasConceptScore W3158536705C1491633281 @default.
• W3158536705 hasConceptScore W3158536705C153911025 @default.
• W3158536705 hasConceptScore W3158536705C185592680 @default.
• W3158536705 hasConceptScore W3158536705C198826908 @default.
• W3158536705 hasConceptScore W3158536705C2781018059 @default.
• W3158536705 hasConceptScore W3158536705C29537977 @default.
• W3158536705 hasConceptScore W3158536705C502942594 @default.
• W3158536705 hasConceptScore W3158536705C55493867 @default.
• W3158536705 hasConceptScore W3158536705C76419328 @default.
• W3158536705 hasConceptScore W3158536705C86803240 @default.
• W3158536705 hasConceptScore W3158536705C95444343 @default.
• W3158536705 hasIssue "6" @default.

• next