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- W3158543876 abstract "Genome manipulation was first made possible in the 1970s when Escherichia coli was first manipulated to produce somatostatin, a therapeutic protein, by fusing this gene to the E. coli beta-galactosidase gene on a plasmid and transforming it into E. coli. Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 technology is a unique tool that can precisely change an organism's DNA. Targeted deletion of the octamer-binding transcription factor 4 (OCT4) gene was created by direct injection of the CRISPR/Cas9 reagent into bovine zygotes and disruption at the bovine OCT4 locus arrested embryonic development at the morula stage and hindered blastocyst formation. Safe applications of CRISPRs in reproduction can guarantee a huge reduction in genetic as well as vector-borne parasitic diseases in humans and animals. CRISPR-Cas9 simply speeds up selective breeding and the producer can choose exactly what genes need to be manipulated from a “catalog” of desirable traits, including reproductive traits in the cattle industry." @default.
- W3158543876 created "2021-05-10" @default.
- W3158543876 creator A5011197614 @default.
- W3158543876 date "2021-05-03" @default.
- W3158543876 modified "2023-10-16" @default.
- W3158543876 title "Application of CRISPR‐Cas9 Technology in Bovine Reproduction" @default.
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- W3158543876 doi "https://doi.org/10.1002/9781119602484.ch91" @default.
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