FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3158578082> ?p ?o ?g. }

• W3158578082 abstract "Abstract Immune evasion of pathogens can modify the course of infection and impact viral persistence and pathology. Here, using different strains of the lymphocytic choriomeningitis virus (LCMV) model system, we show that slower propagation results in limited type I interferon (IFN-I) production and viral persistence. Specifically, cells infected with LCMV-Docile exhibited reduced viral replication when compared to LCMV-WE and as a consequence, infection with LCMV-Docile resulted in reduced activation of bone marrow derived dendritic cells (BMDCs) and IFN-I production in vitro in comparison with LCMV-WE. In vivo, we observed a reduction of IFN-I, T cell exhaustion and viral persistence following infection of LCMV-Docile but not LCMV-WE. Mechanistically, block of intracellular protein transport uncovered reduced propagation of LCMV-Docile when compared to LCMV-WE. This reduced propagation was critical in blunting the activation of the innate and adaptive immune system. When mice were simultaneously infected with LCMV-Docile and LCMV-WE, immune function was restored and IFN-I production, T cell effector functions as well as viral loads were similar to that of mice infected with LCMV-WE alone. Taken together, this study suggests that reduced viral propagation can result in immune evasion and viral persistence." @default.
• W3158578082 created "2021-05-10" @default.
• W3158578082 creator A5002342983 @default.
• W3158578082 creator A5018361659 @default.
• W3158578082 creator A5023895565 @default.
• W3158578082 creator A5029077677 @default.
• W3158578082 creator A5030728705 @default.
• W3158578082 creator A5030811440 @default.
• W3158578082 creator A5047286815 @default.
• W3158578082 creator A5064754125 @default.
• W3158578082 creator A5068285493 @default.
• W3158578082 creator A5071037763 @default.
• W3158578082 creator A5076984925 @default.
• W3158578082 creator A5084894521 @default.
• W3158578082 creator A5085030806 @default.
• W3158578082 creator A5086597104 @default.
• W3158578082 creator A5090253437 @default.
• W3158578082 date "2021-04-29" @default.
• W3158578082 modified "2023-10-12" @default.
• W3158578082 title "Slow viral propagation during initial phase of infection leads to viral persistence in mice" @default.
• W3158578082 cites W1512893349 @default.
• W3158578082 cites W1599424958 @default.
• W3158578082 cites W1976269285 @default.
• W3158578082 cites W1978367598 @default.
• W3158578082 cites W1979778220 @default.
• W3158578082 cites W1986696487 @default.
• W3158578082 cites W2000177767 @default.
• W3158578082 cites W2004228578 @default.
• W3158578082 cites W2004829503 @default.
• W3158578082 cites W2005884645 @default.
• W3158578082 cites W2011647218 @default.
• W3158578082 cites W2014960200 @default.
• W3158578082 cites W2019969899 @default.
• W3158578082 cites W2021417764 @default.
• W3158578082 cites W2024556668 @default.
• W3158578082 cites W2024944874 @default.
• W3158578082 cites W2047742947 @default.
• W3158578082 cites W2048719253 @default.
• W3158578082 cites W2048765000 @default.
• W3158578082 cites W2049868800 @default.
• W3158578082 cites W2050287929 @default.
• W3158578082 cites W2066829476 @default.
• W3158578082 cites W2072158757 @default.
• W3158578082 cites W2077467499 @default.
• W3158578082 cites W2083331853 @default.
• W3158578082 cites W2086084004 @default.
• W3158578082 cites W2088230924 @default.
• W3158578082 cites W2089389204 @default.
• W3158578082 cites W2090530862 @default.
• W3158578082 cites W2095967124 @default.
• W3158578082 cites W2097855813 @default.
• W3158578082 cites W2101910308 @default.
• W3158578082 cites W2104094323 @default.
• W3158578082 cites W2104100784 @default.
• W3158578082 cites W2113051722 @default.
• W3158578082 cites W2114035578 @default.
• W3158578082 cites W2115624659 @default.
• W3158578082 cites W2123358314 @default.
• W3158578082 cites W2133402546 @default.
• W3158578082 cites W2154740067 @default.
• W3158578082 cites W2179216099 @default.
• W3158578082 cites W2267315119 @default.
• W3158578082 cites W2592935721 @default.
• W3158578082 cites W2893620469 @default.
• W3158578082 cites W3016489853 @default.
• W3158578082 cites W70708574 @default.
• W3158578082 doi "https://doi.org/10.1038/s42003-021-02028-x" @default.
• W3158578082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8084999" @default.
• W3158578082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33927339" @default.
• W3158578082 hasPublicationYear "2021" @default.
• W3158578082 type Work @default.
• W3158578082 sameAs 3158578082 @default.
• W3158578082 citedByCount "5" @default.
• W3158578082 countsByYear W31585780822022 @default.
• W3158578082 countsByYear W31585780822023 @default.
• W3158578082 crossrefType "journal-article" @default.
• W3158578082 hasAuthorship W3158578082A5002342983 @default.
• W3158578082 hasAuthorship W3158578082A5018361659 @default.
• W3158578082 hasAuthorship W3158578082A5023895565 @default.
• W3158578082 hasAuthorship W3158578082A5029077677 @default.
• W3158578082 hasAuthorship W3158578082A5030728705 @default.
• W3158578082 hasAuthorship W3158578082A5030811440 @default.
• W3158578082 hasAuthorship W3158578082A5047286815 @default.
• W3158578082 hasAuthorship W3158578082A5064754125 @default.
• W3158578082 hasAuthorship W3158578082A5068285493 @default.
• W3158578082 hasAuthorship W3158578082A5071037763 @default.
• W3158578082 hasAuthorship W3158578082A5076984925 @default.
• W3158578082 hasAuthorship W3158578082A5084894521 @default.
• W3158578082 hasAuthorship W3158578082A5085030806 @default.
• W3158578082 hasAuthorship W3158578082A5086597104 @default.
• W3158578082 hasAuthorship W3158578082A5090253437 @default.
• W3158578082 hasBestOaLocation W31585780821 @default.
• W3158578082 hasConcept C127413603 @default.
• W3158578082 hasConcept C140704245 @default.
• W3158578082 hasConcept C159047783 @default.
• W3158578082 hasConcept C167672396 @default.
• W3158578082 hasConcept C187320778 @default.
• W3158578082 hasConcept C203014093 @default.
• W3158578082 hasConcept C2522874641 @default.
• W3158578082 hasConcept C2776178377 @default.

• next