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- W3158627104 endingPage "1159" @default.
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- W3158627104 abstract "Infection by SARS-CoV-2, the causative agent of COVID-19, is critically connected with host metabolism. Through functional enrichment analysis, the present study aims to evaluate the biological processes involving host proteins interfered by SARS-CoV-2 to verify the potential metabolic impact of the infection. Furthermore, tissue enrichment analyses and differential gene expression of host proteins were applied to understand the interference by SARS-CoV-2 on tissue levels. Results based on functional and tissue-specific enrichment analyses, presented in this study, suggest that SARS-CoV-2, mediated interference on host proteins, can affect the metabolism and catabolism of molecular building blocks and control intracellular mechanisms, including gene expression in metabolism-related organs, to support viral demands. Thus, SARS-CoV-2 can broadly affect the host metabolism and catabolism at tissue and physiological levels contributing to a more severe disease." @default.
- W3158627104 created "2021-05-10" @default.
- W3158627104 creator A5056788739 @default.
- W3158627104 date "2021-05-06" @default.
- W3158627104 modified "2023-10-18" @default.
- W3158627104 title "Functional and tissue enrichment analyses suggest that SARS-CoV-2 infection affects host metabolism and catabolism mediated by interference on host proteins" @default.
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- W3158627104 doi "https://doi.org/10.1007/s42770-021-00497-0" @default.
- W3158627104 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8099703" @default.
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- W3158627104 hasPublicationYear "2021" @default.
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